Cited by 176Cerebrospinal fluid and hydrocephalusBarrier Structure and Function StudiesIon Transport and Channel Regulation

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The Choroid Plexus in Healthy and Diseased Brain

Kaur, Charanjit, Rathnasamy, Gurugirijha, Ling, Eng-Ang·2016·Journal of Neuropathology & Experimental Neurology

DOI 10.1093/jnen/nlv030

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Abstract

The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells produce the cerebrospinal fluid (CSF), which has many functions including rendering mechanical support, providing a route for some nutrients, removing by-products of metabolism and synaptic activity, and playing a role in hormonal signaling. The choroid plexus synthesizes many growth factors, including insulin-like, fibroblast, and platelet-derived growth factors. The tight junctions located between the apical parts of the choroid plexus epithelial cells form the blood-CSF barrier (BCSFB), which is crucial for the homeostatic regulation of the brain microenvironment along with the blood-brain barrier (BBB). Morphological changes such as atrophy of the epithelial cells and thickening of the basement membrane suggest altered CSF production occurs in aging and in Alzheimer disease. In brain injuries and infections, leukocytes accumulate in the CSF by passing through the choroid plexus. In inflammatory CNS diseases (eg, multiple sclerosis), pathogenic autoreactive T lymphocytes may migrate through the BBB and BCSFB into the CNS. The development of therapeutic strategies to mitigate disruption of the BCSFB may be helpful to curtail the entry of inflammatory cells into the CSF and hence reduce inflammation, thereby overcoming choroid plexus dysfunction in senescence and in various diseases of the CNS.

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See all 176

Authors: Kaur, C., Rathnasamy, G., & Ling, E.-A.
Affiliations: National University of Singapore (SG)
ORCID: Kaur, Charanjit
Rathnasamy, Gurugirijha
Ling, Eng-Ang
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2016-02-17
Volume: 75
Issue: 3
Pages: 198-213
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1093/jnen/nlv030
OpenAlex: W2281330516
Cited by: 176
References: 267
Citations by year: 2026: 16 · 2025: 22 · 2024: 21 · 2023: 14 · 2022: 21 · 2021: 27 · 2020: 14 · 2019: 22 · 2018: 5 · 2017: 11 · 2016: 3
FWCI: 1.50
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: choroid plexus, cerebrospinal fluid production, blood-CSF barrier, choroid plexus epithelial cells, tight junctions, growth factors, aging, Alzheimer's disease, brain injury, central nervous system infection, multiple sclerosis, autoreactive T cells, leukocyte transmigration, blood-brain barrier
MeSH terms: Animals, Blood-Brain Barrier, Brain Diseases, Choroid Plexus, Humans, Tight Junctions

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The Choroid Plexus in Healthy and Diseased Brain

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