Trisomy of chromosome R confers resistance to triazoles in Candida albicans
Abstract
Genome plasticity is a hallmark of Candida albicans, and it has been suggested that it generates numerical and structural genomic variations as a means of adaptation. In this study, we used array based comparative genomic hybridization technology and the quantitative real time PCR to investigate the mechanisms by which the following strains obtained by genetic manipulation, CaLY188, CaLY350, CaLY190 and CaLY191, were resistant to antifungal azoles. All four showed trisomy of chromosome R and resistance to azoles. Serial passage of CaLY188 in drug-free medium resulted in chromosome loss, causing chromosome R disomy and loss of azole resistance. Thus we proposed that trisomy of chromosome R contributes to azole resistance.
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In 2015, the first clinical isolate containing putative gain-of-function mutations in the ZCF Mrr2 was described, possessing amino acid substitutions that appeared to increase CDR1 but not CDR2 expression.
“In 2015, the first clinical isolate containing putative gain-of-function mutations in the ZCF Mrr2 was described, possessing amino acid substitutions that appeared to increase CDR1 but not CDR2 expression.117”
From Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus<i>Candida albicans</i> (2020) · cites this paper as [117]
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- Authors
- Li, X., Yang, F., Li, D., Zhou, M., Wang, X., Xu, Q., Zhang, Y., Yan, L., & Jiang, Y.
- Affiliations
- Second Military Medical University (CN)
- Tel Aviv University (IL)
- China Pharmaceutical University (CN)
- Fujian University of Traditional Chinese Medicine (CN)
- Corresponding author
- Yan, Lan
- Jiang, Yuanying
- Venue
- Medical Mycology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-03-19
- Volume
- 53
- Issue
- 3
- Pages
- 302-309
- ISSN
- 0268-1218 (ISSN-L)
- 1460-2709
- 1369-3786
- OpenAlex
- W2085752473
- Cited by
- 28
- References
- 12
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Mycology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida albicans, trisomy, azole resistance, genome plasticity, chromosome loss, drug resistance mechanisms
- MeSH terms
- Antifungal Agents, Candida albicans, Serial Passage, Triazoles, Trisomy, Chromosomes, Fungal, Drug Resistance, Fungal
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