The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Soft Sweeps II—Molecular Population Genetics of Adaptation from Recurrent Mutation or Migration
Abstract
In the classical model of molecular adaptation, a favored allele derives from a single mutational origin. This ignores that beneficial alleles can enter a population recurrently, either by mutation or migration, during the selective phase. In this case, descendants of several of these independent origins may contribute to the fixation. As a consequence, all ancestral haplotypes that are linked to any of these copies will be retained in the population, affecting the pattern of a selective sweep on linked neutral variation. In this study, we use analytical calculations based on coalescent theory and computer simulations to analyze molecular adaptation from recurrent mutation or migration. Under the assumption of complete linkage, we derive a robust analytical approximation for the number of ancestral haplotypes and their distribution in a sample from the population. We find that so-called "soft sweeps," where multiple ancestral haplotypes appear in a sample, are likely for biologically realistic values of mutation or migration rates.
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Citations
Cites
The hitch-hiking effect of a favourable gene
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Cited by
Adaptation from standing genetic variation
BARRETT, R., & SCHLUTER, D. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2007.09.008 · Cited by 2,091
The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
Pritchard, J. K., Pickrell, J. K., & Coop, G. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.055 · Cited by 932
“For traits where the mutational target size is hundreds of base pairs or more, we can expect that adaptation from standing variation is likely to be the rule and, additionally, that very often multiple favored mutations may sweep up simultaneously, with none reaching fixation during the selective sweep [47].”
Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions
Hoban, S., Kelley, J. L., Lotterhos, K. E., Antolin, M. F., Bradburd, G., Lowry, D. B., Poss, M. L., Reed, L. K., Storfer, A., & Whitlock, M. C. (2016) · The American Naturalist · doi:10.1086/688018 · Cited by 876
“Recent theoretical work suggests that soft sweeps may be common (Pennings and Hermisson 2006; Ralph and Coop 2010, 2015; but see Jensen 2014).”
Detecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
The role of geography in human adaptation
Coop, G., Pickrell, J. K., Novembre, J., Kudaravalli, S., Li, J., Absher, D., Myers, R. M., Cavalli-Sforza, L. L., Feldman, M. W., & Pritchard, J. K. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000500 · Cited by 412
Evidence that adaptation in Drosophila is not limited by mutation at single sites
Karasov, T., Messer, P. W., & Petrov, D. A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000924 · Cited by 257
Parallel adaptation: one or many waves of advance of an advantageous allele?
Ralph, P., & Coop, G. (2010) · Genetics · doi:10.1534/genetics.110.119594 · Cited by 165
Distinguishing between selective sweeps from standing variation and from a de novo mutation
Peter, B. M., Huerta-Sanchez, E., & Nielsen, R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003011 · Cited by 193
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Excess of genomic defects in a woolly mammoth on Wrangel island
Rogers, R. L., & Slatkin, M. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006601 · Cited by 134
Detection of selective sweeps in structured populations: a comparison of recent methods
Vatsiou, A. I., Bazin, E., & Gaggiotti, O. E. (2016) · Molecular Ecology · doi:10.1111/mec.13360 · Cited by 111
Albert, F. W., Hodges, E., Jensen, J. D., Besnier, F., Xuan, Z., Rooks, M., Bhattacharjee, A., Brizuela, L., Good, J. M., Green, R. E., et al. (2011) · Heredity · doi:10.1038/hdy.2011.4 · Cited by 28
Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues
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Metadata
- Authors
- Pennings, P. S., & Hermisson, J.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-06
- Volume
- 23
- Issue
- 5
- Pages
- 1076-1084
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2098615058
- Cited by
- 323
- References
- 1
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
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