The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments
Open accessAbstract
Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8-9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change.
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Citations
Cites
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BackgroundThe yak genome and adaptation to life at high altitude
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Cited by
Evolutionary genomics can improve prediction of species’ responses to climate change
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Self-citationWhole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness
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Metadata
- Authors
- Yang, J., Li, W.-R., Lv, F.-H., He, S.-G., Tian, S.-L., Peng, W.-F., Sun, Y.-W., Zhao, Y.-X., Tu, X.-L., Zhang, M., Xie, X.-L., Wang, Y.-T., Li, J.-Q., Liu, Y.-G., Shen, Z.-Q., Wang, F., Liu, G.-J., Lu, H.-F., Kantanen, J., Han, J.-L., Li, M.-H., & Liu, M.-J.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-08
- Volume
- 33
- Issue
- 10
- Pages
- 2576-2592
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2463065542
- Cited by
- 342
- References
- 15
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, J., Li, W.-R., Lv, F.-H., He, S.-G., Tian, S.-L., Peng, W.-F., Sun, Y.-W., Zhao, Y.-X., Tu, X.-L., Zhang, M., Xie, X.-L., Wang, Y.-T., Li, J.-Q., Liu, Y.-G., Shen, Z.-Q., Wang, F., Liu, G.-J., Lu, H.-F., Kantanen, J., . . . Liu, M.-J. (2016). Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments. Molecular Biology and Evolution. https://doi.org/10.1093/molbev/msw129
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