Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness
Open accessAbstract
Wool fineness affects the quality of wool, and some studies have identified about forty candidate genes that affect sheep wool fineness, but these genes often reveal only a certain proportion of the variation in wool thickness. We further explore additional genes associated with the fineness of sheep wool. Whole-genome resequencing of eight sheep breeds was performed to reveal selection signals associated with wool fineness, including four coarse wool and four fine/semi-fine wool sheep breeds. Multiple methods to reveal selection signals (Fst and θπ Ratio and XP-EHH) were applied for sheep wool fineness traits. In total, 269 and 319 genes were annotated in the fine wool (F vs. C) group and the coarse wool (C vs. F) group, such as LGR4, PIK3CA, and SEMA3C and NFIB, OPHN1, and THADA. In F vs. C, 269 genes were enriched in 15 significant GO Terms (p < 0.05) and 38 significant KEGG Pathways (p < 0.05), such as protein localization to plasma membrane (GO: 0072659) and Inositol phosphate metabolism (oas 00562). In C vs. F, 319 genes were enriched in 21 GO Terms (p < 0.05) and 16 KEGG Pathways (p < 0.05), such as negative regulation of focal adhesion assembly (GO: 0051895) and Axon guidance (oas 04360). Our study has uncovered genomic information pertaining to significant traits in sheep and has identified valuable candidate genes. This will pave the way for subsequent investigations into related traits.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Variants of keratin and keratin-associated protein genes have been shown to associate with wool quality and are potential selection markers for livestock improvements.
“Importantly, variants of these genes have been shown to associate with wool quality, and are potential selection markers for livestock improvements164–167.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [167]
The Introduction (page not provided) reports a mutant KRT74 linked to finer wool and says KAP genes may affect wool fineness. The Discussion §4.2 (page not provided) relates KRT and KAP expression to finer wool, but does not establish KAP variants as associated with wool quality or identify variants of these genes as selection markers for livestock improvement. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.
Tamura, K., Stecher, G., Peterson, D., Filipski, A., & Kumar, S. (2013) · Molecular biology and evolution · doi:10.1093/molbev/mst197 · Cited by 41,174 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
ESTIMATING F -STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE
Weir, B. S., & Cockerham, C. C. (1984) · Evolution · doi:10.1111/j.1558-5646.1984.tb05657.x · Cited by 18,909 · see citing works
The variant call format and VCFtools
Danecek, P., Auton, A., Abecasis, G. R., Albers, C. A., Banks, E., DePristo, M. A., Handsaker, R. E., Lunter, G. A., Marth, G., Sherry, S. T., et al. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr330 · Cited by 16,008 · see citing works
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq603 · Cited by 14,380 · see citing works
Estimating F-Statistics for the Analysis of Population Structure
Weir, B. S., & Cockerham, C. C. (1984) · Evolution · doi:10.2307/2408641 · Cited by 11,023 · see citing works
Fast model-based estimation of ancestry in unrelated individuals
Alexander, D. H., Novembre, J., & Lange, K. (2009) · Genome Research · doi:10.1101/gr.094052.109 · Cited by 9,898 · see citing works
Interactive Tree Of Life (iTOL) v4: recent updates and new developments
Letunić, I., & Peer Bork, B. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz239 · Cited by 5,988 · see citing works
A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,847 · see citing works
Foll, M., & Gaggiotti, O. E. (2008) · Genetics · doi:10.1534/genetics.108.092221 · Cited by 2,748 · see citing works
Genome-wide detection and characterization of positive selection in human populations
The International HapMap Consortium, Sabeti, P. C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E. H., McCarroll, S. A., et al. (2007) · Nature · doi:10.1038/nature06250 · Cited by 2,131 · see citing works
Scheet, P. A., & Stephens, M. (2006) · The American Journal of Human Genetics · doi:10.1086/502802 · Cited by 1,949 · see citing works
Bu, D., Luo, H., Huo, P., Wang, Z., Zhang, S., He, Z., Wu, Y., Zhao, L., Liu, J., Guo, J., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab447 · Cited by 1,887 · see citing works
Positive Natural Selection in the Human Lineage
Sabeti, P. C., Schaffner, S. F., Fry, B., Lohmueller, J., Varilly, P., Shamovsky, O., Palma, A., Mikkelsen, T. S., Altshuler, D., & Lander, E. S. (2006) · Science · doi:10.1126/science.1124309 · Cited by 1,157 · see citing works
Sonic hedgehog signaling is essential for hair development
St‐Jacques, B., Dassule, H. R., Karavanova, I. D., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70443-9 · Cited by 764 · see citing works
Genetical Structure of Populations
Wright, S. (1950) · Nature · doi:10.1038/166247a0 · Cited by 629 · see citing works
Weighted Neighbor Joining: A Likelihood-Based Approach to Distance-Based Phylogeny Reconstruction
Bruno, W. J., Socci, N. D., & Halpern, A. L. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026231 · Cited by 512 · see citing works
Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis
Chiang, C. C., Swan, R. Z., Grachtchouk, M. A., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A., et al. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9103 · Cited by 497 · see citing works
Correction: A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040154 · Cited by 386 · see citing works
Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.011 · Cited by 363 · see citing works
Yang, J. H., Li, W., Lv, F., He, S., Tian, S., Peng, W., Sun, Y., Zhao, Y., Tu, X.-L., Zhang, M., et al. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw129 · Cited by 342 · see citing works
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle developmentPreprint
Mill, P., Mo, R., Fu, H. E., Grachtchouk, M. A., Kim, P. C. W., Dlugosz, A. A., & Hui, C. (2003) · Genes & Development · doi:10.1101/gad.1038103 · Cited by 326 · see citing works
Kasper, M., Schnidar, H., Neill, G. W., Hanneder, M., Klingler, S., Blaas, L., Schmid, C., Hauser‐Kronberger, C., Regl, G., Philpott, M. P., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02317-05 · Cited by 219 · see citing works
Androgens and androgen receptor action in skin and hair follicles
Ceruti, J. M., Leirós, G. J., & Balañá, M. E. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.009 · Cited by 212 · see citing works
Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate
Zhang, Y., Andl, T., Yang, S. H., Teta, M., Liu, F., Seykora, J. T., Tobias, J. W., Piccolo, S., Schmidt‐Ullrich, R., Nagy, A., et al. (2008) · Development · doi:10.1242/dev.017459 · Cited by 193 · see citing works
Fu, D., Huang, J., Li, K., Chen, Y., He, Y., Sun, Y., Guo, Y., Du, L., Qu, Q., Miao, Y., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111247 · Cited by 191 · see citing works
Fan, W., Yanase, T., Morinaga, H., Okabe, T., Nomura, M., Daitoku, H., Fukamizu, A., Kato, S., Takayanagi, R., & Nawata, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610447200 · Cited by 189 · see citing works
Genome-wide analysis reveals adaptation to high altitudes in Tibetan sheep
Wei, C., Wang, H., Liu, G., Zhao, F., Kijas, J., Ma, Y., Lu, J., Zhang, L., Cao, J., Wu, M., et al. (2016) · Scientific Reports · doi:10.1038/srep26770 · Cited by 164 · see citing works
Self-citationSelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics
Hung, R., Spaeth, C. S., Yesilyurt, H. G., & Terman, J. R. (2013) · Nature Cell Biology · doi:10.1038/ncb2871 · Cited by 149 · see citing works
Rogers, M. A., Winter, H., Schweizer, J., Langbein, L., & Praetzel, S. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12087.x · Cited by 130 · see citing works
Genome-Wide Association Study for Wool Production Traits in a Chinese Merino Sheep Population
Wang, Z., Zhang, H., Yang, H., Wang, S., Rong, E., Pei, W., Li, H., & Wang, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107101 · Cited by 127 · see citing works
Utsunomiya, Y. T., O’Brien, A. M. P., Sonstegard, T. S., Tassell, C. P. V., do Carmo, A. S., Mészáros, G., Sölkner, J., & Garcia, J. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064280 · Cited by 108 · see citing works
Shh Controls Epithelial Proliferation via Independent Pathways that Converge on N-Myc
Mill, P., Mo, R., Hu, M., Dagnino, L., Rosenblum, N. D., & Hui, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.009 · Cited by 107 · see citing works
Adam, R. C., Yang, H., Ge, Y., Infarinato, N. R., Gur‐Cohen, S., Miao, Y., Wang, P., Zhao, Y., Lu, C. P.-J., Kim, J. E., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0513-0 · Cited by 94 · see citing works
Teta, M., Choi, Y. S., Okegbe, T., Wong, G. S., Tam, O. H., Chong, M. M. W., Seykora, J. T., Nagy, A., Littman, D. R., Andl, T., et al. (2012) · Development · doi:10.1242/dev.070920 · Cited by 93 · see citing works
Zhao, B., Luo, H., He, J., Huang, X., Chen, S., Fu, X., Zeng, W., Tian, Y., Liu, S., Li, C., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-01127-9 · Cited by 93 · see citing works
Langbein, L., Praetzel, S., Rogers, M. A., Aoki, N., Winter, H., & Schweizer, J. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01711.x · Cited by 90 · see citing works
FoxO1 – the key for the pathogenesis and therapy of acne?
Melnik, B. C. (2010) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07344.x · Cited by 90 · see citing works
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state
Liu, Y., Guerrero‐Juarez, C. F., Xiao, F., Shettigar, N. U., Ramos, R., Kuan, C., Lin, Y., Lomeli, L. M., Park, J. M., Oh, J. W., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.06.005 · Cited by 87 · see citing works
Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes
Kalds, P., Zhou, S., Gao, Y., Cai, B., Huang, S., Chen, Y., & Wang, X. (2022) · Genetics Selection Evolution · doi:10.1186/s12711-022-00753-3 · Cited by 85 · see citing works
Langbein, L., Rogers, M. A., Praetzel‐Wunder, S., Helmke, B. M., Schirmacher, P., & Schweizer, J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700494 · Cited by 83 · see citing works
Jin, G., Sun, J., Kim, S.-T., Feng, J., Wang, Z., Tao, S., Chen, Z., Purcell, L., Smith, S., Isaacs, W. B., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds361 · Cited by 83 · see citing works
Russell, L. E., Harrison, W. J., Bahta, A. W., Zouboulis, C. C., Burrin, J. M., & Philpott, M. P. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00612.x · Cited by 76 · see citing works
A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR
Wolf, S. S., Patchev, V. K., & Obendorf, M. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.01.017 · Cited by 76 · see citing works
NFI Transcription Factors Interact with FOXA1 to Regulate Prostate-Specific Gene Expression
Grabowska, M. M., Elliott, A. D., DeGraff, D. J., Anderson, P. D., Anumanthan, G., Yamashita, H., Sun, Q., Friedman, D. B., Hachey, D. L., Yu, X., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1213 · Cited by 75 · see citing works
Mohri, Y., Kato, S., Umezawa, A., Okuyama, R., & Nishimori, K. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21639 · Cited by 70 · see citing works
Identification of selection signals by large-scale whole-genome resequencing of cashmere goats
Li, X., Su, R., Wan, W., Zhang, W., Jiang, H., Qiao, X., Fan, Y., Zhang, Y., Wang, R., Liu, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15516-0 · Cited by 69 · see citing works
Self-citationWu, H. G., Stanley, J. R., & Cotsarelis, G. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12234.x · Cited by 68 · see citing works
Megdiche, S., Mastrangelo, S., Hamouda, M. B., Lenstra, J. A., & Ciani, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01025 · Cited by 54 · see citing works
Zhao, B., Luo, H., Huang, X., Chen, W., Di, J., Tian, Y., Fu, X., Li, B., Liu, G. E., Fang, L., et al. (2021) · Genetics Selection Evolution · doi:10.1186/s12711-021-00649-8 · Cited by 54 · see citing works
Jin, M., Lu, J., Fei, X., Lu, Z., Quan, K., Liu, Y., Chu, M., Di, R., Wei, C., & Wang, H. (2020) · Animals · doi:10.3390/ani10091599 · Cited by 50 · see citing works
Self-citationCommon polymorphisms in WNT10A affect tooth morphology as well as hair shape
Kimura, R., Watanabe, C., Kawaguchi, A., Kim, Y., Park, S., Maki, K., Ishida, H., & Yamaguchi, T. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv014 · Cited by 49 · see citing works
Du, K.-T., Deng, J.-Q., He, X., Liu, Z.-P., Peng, C., & Zhang, M. (2018) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-018-0118-x · Cited by 48 · see citing works
Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression
Gao, X., Dai, C. S., Huang, S., Tang, J., Chen, G., Li, J., Zhu, Z., Zhu, X., Zhou, S., Gao, Y., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2392 · Cited by 48 · see citing works
Zhao, H., Guo, T., Lu, Z., Liu, J., Zhu, S., Qiao, G., Han, M. L. K., Yuan, C., Wang, T., Li, F., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-07399-3 · Cited by 47 · see citing works
Self-citationZhao, R., Li, J., Liu, N., Li, H., Liu, L., Yang, F., Li, L., Wang, Y., & He, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00590 · Cited by 44 · see citing works
Detection of Signatures of Selection Using F ST
Porto-Neto, L. R., Lee, S. H., Lee, H., & Gondro, C. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-447-0_19 · Cited by 41 · see citing works
Genome‐wide association study of fleece traits in Inner Mongolia Cashmere goats
Wang, F., Zhang, L., Gong, G., Yan, X. C., Zhang, L. T., Zhang, F., Liu, H. F., Lv, Q., Wang, Z. Y., Wang, R. J., et al. (2021) · Animal Genetics · doi:10.1111/age.13053 · Cited by 41 · see citing works
Hair curvature: a natural dialectic and review
Nissimov, J., & Chaudhuri, A. B. D. (2014) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12081 · Cited by 40 · see citing works
Udhane, S. S., Pandey, A. V., Hofer, G., Mullis, P. E., & Flück, C. E. (2015) · Scientific Reports · doi:10.1038/srep10132 · Cited by 38 · see citing works
Li, S., Chen, W., Zheng, X., Liu, Z., Yang, G., Hu, X., & Mou, C. (2020) · Gene · doi:10.1016/j.gene.2020.144968 · Cited by 33 · see citing works
Drivers of plateau adaptability in cashmere goats revealed by genomic and transcriptomic analyses
Wu, C., Ma, S., Zhao, B., Qin, C., Wu, Y., Di, J., Suo, L., & Fu, X. (2023) · BMC Genomics · doi:10.1186/s12864-023-09333-1 · Cited by 33 · see citing works
Lee, S., Na, Y.-P., & Lee, J.-B. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/s0190-9622(03)01485-3 · Cited by 32 · see citing works
Melnik, B. C. (2010) · PubMed · Cited by 31 · see citing works
Genome-Wide Scan of Wool Production Traits in Akkaraman Sheep
Arzik, Y., Kizilaslan, M., Behrem, S., White, S. N., Piel, L. M. W., & Cinar, M. U. (2023) · Genes · doi:10.3390/genes14030713 · Cited by 31 · see citing works
Lgr4 Deletion Delays the Hair Cycle and Inhibits the Activation of Hair Follicle Stem Cells
Ren, X., Xia, W., Xu, P., Shen, H., Dai, X., Liu, M., Shi, Y., Ye, X., & Dang, Y. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.12.034 · Cited by 30 · see citing works
Song, C. S., Jung, M. H., Supakar, P. C., Chatterjee, B., & Roy, A. K. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0350 · Cited by 29 · see citing works
Shi, R., Li, S., Liu, P., Zhang, S., Wu, Z.-H., Wu, T., Gong, S., & Wan, Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265989 · Cited by 28 · see citing works
Gene expression of type 2 17β hydroxysteroid dehydrogenase in scalp hairs of hirsute women
Oliveira, I. O., Lhullier, C., Brum, I. S., & Spritzer, P. M. (2003) · Steroids · doi:10.1016/s0039-128x(03)00093-x · Cited by 27 · see citing works
Ramos, Z., Garrick, D. J., Blair, H. T., Barbieri, I. D., Ciappesoni, G., Montossi, F., & Kenyon, P. R. (2023) · Journal of Animal Science · doi:10.1093/jas/skad071 · Cited by 26 · see citing works
DDB2 is a novel AR interacting protein and mediates AR ubiquitination/degradation
Chang, S., Su, C.-H., Chen, H.-H., Huang, C.-W., Tsao, L.-P. B., Tsao, Y., & Chen, S. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.023 · Cited by 25 · see citing works
Wang, S., Wu, T., Sun, J., Li, Y., Yuan, Z., & Sun, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.800157 · Cited by 25 · see citing works
Self-citationZhongyi, S., Rantakari, P., Lamminen, T., Toppari, J., & POUTANEN, M. H. (2007) · Endocrinology · doi:10.1210/en.2007-0365 · Cited by 23 · see citing works
Sun, X., Jiang, J., Wang, G., Zhou, P., Li, J., Chen, C., Liu, L., Li, N., Xia, Y., & Ren, H. (2022) · Animal Bioscience · doi:10.5713/ab.21.0577 · Cited by 23 · see citing works
Seroussi, E., Rosov, A., Shirak, A., Lam, A., & Gootwine, E. (2017) · Genetics Selection Evolution · doi:10.1186/s12711-017-0296-3 · Cited by 22 · see citing works
Ye, R., Tian, Y., Huang, Y., Zhang, Y., Wang, J., Sun, X., Zhou, H., Zhang, D., & Pan, W. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01065 · Cited by 22 · see citing works
Zhang, M., Sun, Y., Huang, C., Luo, J., Zhang, L., Meng, J., Liang, C. Y., & Chang, C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03966-4 · Cited by 21 · see citing works
Cai, B., Li, M., Zheng, Y., Yin, Y., Jin, F., Li, X., Dong, J., Jiao, X., Liu, X., Zhang, K., et al. (2020) · Aging · doi:10.18632/aging.103165 · Cited by 20 · see citing works
Transcriptome analysis reveals genes associated with wool fineness in merinos
Ma, S., Li, L., Huang, X., Tian, K., Tian, Y., Wu, C., & Zhao, Z. (2023) · PeerJ · doi:10.7717/peerj.15327 · Cited by 20 · see citing works
Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis
Brennan-Crispi, D. M., Hossain, C., Sahu, J., Brady, M., Galdo, N. A. R., & Mahoney, M. G. (2015) · Oncotarget · doi:10.18632/oncotarget.3309 · Cited by 17 · see citing works
Wang, F., Zha, Z., He, Y., Li, J., Zhong, Z., Xiao, Q., & Tan, Z. (2023) · Animals · doi:10.3390/ani13111835 · Cited by 17 · see citing works
Yu, M., Bell, R. H., Ho, M. M., Leung, G., Haegert, A. M., Carr, N. J., Shapiro, J., & McElwee, K. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034185 · Cited by 14 · see citing works
Actin bundles in human hair follicles as revealed by confocal laser microscopy
Furumura, M., & Ishikawa, H. (1996) · Cell and Tissue Research · doi:10.1007/s004410050553 · Cited by 13 · see citing works
Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness
Hochfeld, L. M., Bertolini, M., Broadley, D., Botchkareva, N. V., Betz, R. C., Schoch, S., Nöthen, M. M., & Heilmann‐Heimbach, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256846 · Cited by 13 · see citing works
Wang, H., Guo, M., Shen, S., He, L., Zhang, X., Zuo, X., & Yang, S. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12754 · Cited by 11 · see citing works
Self-citationTwo mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep
Liang, B., Bai, T., Zhao, Y., Han, J., He, X., Pu, Y., Wang, C., Liu, W., Ma, Q., Tian, K., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.04.012 · Cited by 11 · see citing works
Cai, W., Xu, Y., Bai, Z., Lin, G., Wang, L., Dou, X., Han, D., Wang, Z., Wang, J., Zhang, X., et al. (2022) · Animal Biotechnology · doi:10.1080/10495398.2022.2088550 · Cited by 10 · see citing works
Tian, Y., Usman, Τ., Tian, K. C., Di, J., Huang, X. X., Xu, X., Tulafu, H., Wu, W. W., Fu, X. F., Bai, Y., et al. (2017) · Genetics and Molecular Research · doi:10.4238/gmr16018905 · Cited by 9 · see citing works
Thulabandu, V., Nehila, T. E., Ferguson, J. W., & Atit, R. P. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.06.008 · Cited by 9 · see citing works
Valipour, S., Karimi, K., Do, D. N., Barrett, D., Sargolzaei, M., Plastow, G. S., Wang, Z., & Miar, Y. (2022) · Genes · doi:10.3390/genes13111939 · Cited by 8 · see citing works
Krugluger, W., Stiefsohn, K., Moser, K., Moser, C., & Laciak, K. (2017) · Dermatologic Surgery · doi:10.1097/dss.0000000000000971 · Cited by 6 · see citing works
Drzewiecka, H., Jarmołowska‐Jurczyszyn, D., Kluk, A., Gałęcki, B., Dyszkiewicz, W., & Jagodziński, P. P. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5014 · Cited by 6 · see citing works
Zhong, H., Chu, Q., Xiang, J. J., Zhang, A. L., Chen, E. Q., Shen, X., & Liao, X. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10065 · Cited by 6 · see citing works
Flagged first, then by citations
2 of the 98 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Genomic Insights into Tibetan Sheep Adaptation to Different Altitude Environments
Zhang, W., Yuan, C., An, X., Guo, T., Wei, C., Lu, Z., & Liu, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212394 · Cited by 15 · see citing works
Self-citationGenomic Characterization of Quality Wool Traits in Spanish Merino Sheep
Anaya, G., Laseca, N., Granero, A., Ziadi, C., Molina, F. A. A., Domingo, A., & Molina, A. (2024) · Genes · doi:10.3390/genes15060795 · Cited by 14 · see citing works
Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery
Zhang, W., Luosang, C., Yuan, C., Guo, T., Wei, C., Liu, J., & Lu, Z. (2024) · BMC Genomics · doi:10.1186/s12864-024-10464-2 · Cited by 14 · see citing works
Self-citationWhole-Genome Resequencing in Sheep: Applications in Breeding, Evolution, and Conservation
Ma, R., Lu, Y. C., Li, M., Gao, Z., Li, D., Gao, Y., Deng, W., & Wang, B. (2025) · Genes · doi:10.3390/genes16040363 · Cited by 13 · see citing works
Pu, X., Ma, S., Zhao, B., Tang, S. L., Lu, Q., Liu, W., Wang, Y., Cen, Y., Wu, C., & Fu, X. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1401369 · Cited by 12 · see citing works
Song, Y., Yuan, C., An, X., Guo, T., Zhang, W., Lu, Z., & Liu, J. (2024) · Animals · doi:10.3390/ani14223212 · Cited by 11 · see citing works
Self-citationWhole genome sequences of 297 Duolang sheep for litter size
Fang, C., Druet, T., Cao, H., Liu, W., Chen, Q., & Farnir, F. (2025) · Scientific Data · doi:10.1038/s41597-025-05448-0 · Cited by 11 · see citing works
Wang, Q., Lu, Y. C., Li, M., Gao, Z., Li, D., Gao, Y., Deng, W., & Wu, J. (2025) · Animals · doi:10.3390/ani15060831 · Cited by 10 · see citing works
Pang, Z., Yang, P., Cai, K., Wang, W., Afe, A. E., Pan, Y., Qiao, L., & Liu, W. (2025) · BMC Genomics · doi:10.1186/s12864-025-12281-7 · Cited by 6 · see citing works
Sheep litter size heredity basis using genome‐wide selective analysis
Cui, W., Wang, H., Li, J., Lv, D., Xu, J., Liu, M. C., & Yin, G. (2024) · Reproduction in Domestic Animals · doi:10.1111/rda.14689 · Cited by 6 · see citing works
Self-citationHe, Z., Zhao, F., Sun, H., Hu, J., Wang, J., Liu, X., Li, M., Hao, Z., Zhao, Z., Shi, B., et al. (2025) · BMC Genomics · doi:10.1186/s12864-024-11195-0 · Cited by 6 · see citing works
Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4 · see citing works
Zhao, B., Yu, Y., Sun, S., Cai, J., Bao, Z., Chen, Y., & Wu, X. (2024) · Veterinary Sciences · doi:10.3390/vetsci11120651 · Cited by 4 · see citing works
Zhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · BMC Genomics · doi:10.1186/s12864-024-10535-4 · Cited by 4 · see citing works
Self-citationGenome-wide selection signal analysis reveals the adaptability of Tibetan sheep to high altitudes
Song, Y., Yuan, C., Guo, T., Chen, B., Wang, F., Lu, Z., & Liu, J. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1632017 · Cited by 3 · see citing works
Self-citationGenetic and non‐genetic factors influencing lambskin traits: A review
Habtegiorgis, K., Xie, J., Tariq, M., Quddus, A., & Mao, D. (2025) · Animal Genetics · doi:10.1111/age.70061 · Cited by 3 · see citing works
Two-Stage Machine Learning-Based GWAS for Wool Traits in Central Anatolian Merino Sheep
Arzık, Y., Kızılaslan, M., Behrem, S., Tütenk, S., & Çınar, M. U. (2025) · Agriculture · doi:10.3390/agriculture15212287 · Cited by 2 · see citing works
Selection Signatures in the Genome of Dzhalgin Merino Sheep Breed
Krivoruchko, A. Y., Yatsyk, O. A., Skokova, A. V., Safaryan, E. Y., Usai, L., & Александровна, К. А. (2025) · Animals · doi:10.3390/ani15192871 · Cited by 1 · see citing works
Falchi, L., Rochus, C. M., Špehar, M., Ramljak, J., Kasap, A., Macciotta, N. P. P., Pocrnić, I., & Cesarani, A. (2025) · Small Ruminant Research · doi:10.1016/j.smallrumres.2025.107654 · Cited by 1 · see citing works
Xiao, T., Guo, T., Yuan, C., Zhang, W., Luo, Y., Tang, J., Lu, Z., Liang, B., & Liu, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1764812 · Cited by 1 · see citing works
Self-citationScreening of Protein Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep
He, Z., Tian, L., Wang, G., Zhao, F., Zhao, P., Zhang, S., Li, S., & Yang, G. (2025) · Animals · doi:10.3390/ani15172578 · Cited by 1 · see citing works
Genetic Polymorphism Reveals FAT3 Gene Associations with Wool Traits in Subo Merino Sheep
Anwar, A., Amar, G., Zhao, W., Liu, W., Ma, S., Tang, S. L., Wu, C., & Fu, X. (2025) · Animals · doi:10.3390/ani15172534
Functional genes for wool traits and coat colors
Li, M.-H., & Salehian-Dehkordi, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-43994-0.00016-2
Zhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26740193
Self-citationZhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26740196
Self-citationZhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26740190
Self-citationZhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26740202
Self-citationZhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26740205
Self-citationZhang, W., Lu, Z., Guo, T., Yuan, C., & Liu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26740199
Self-citationAnalysis of Migration and Adaptive Evolution in Tibetan Sheep Populations
Zhang, W., Yuan, C., Guo, T., Chen, B., Fan, W., Liu, J., & Lu, Z. (2026) · Animals · doi:10.3390/ani16020317
Self-citationTaheri, S., Karimi, M. O., Saedi, N., Zerehdaran, S., Shariati, M. M., Gholizadeh, M., & Javadmanesh, A. (2026) · PLoS ONE · doi:10.1371/journal.pone.0350262
Association of KRTAP24-1 Gene Polymorphisms with Wool Traits in Tibetan Sheep (Ovis aries)
Zhao, H., Ma, S., Sun, W., Lu, Y., & Jin, X. (2026) · Animals · doi:10.3390/ani16132111
Whole‐Genome Resequencing Reveals Selection Signatures Associated With Lambskin Patterns in Hu Sheep
Habtegiorgis, K., Xie, J., Tariq, M., Quddus, A., Wang, D., Zhao, B., & Mao, D. (2026) · Animal Genetics · doi:10.1002/age.70186
Sattar, M., Parhat, S., YanPing, M., Wufuer, G., Zhang, X., Wei, N., Tian, J., Gao, R., Sulayman, A., & Tian, Y. (2026) · Animals · doi:10.3390/ani16203205
- Authors
- Zhang, W., Jin, M., Li, T., Lu, Z., Wang, H., Yuan, Z., & Wei, C.
- Affiliations
- Chinese Academy of Agricultural Sciences (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
- Yangzhou University (CN)
- Corresponding author
- Wei, Caihong
- Venue
- Animals
- Publisher
- MDPI AG
- Published
- 2023-09-16
- Volume
- 13
- Issue
- 18
- Pages
- 2944
- ISSN
- 2076-2615 (ISSN-L)
- PMC
- PMC10526036
- OpenAlex
- W4386838427
- Cited by
- 30
- References
- 98
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 11
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animals (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (32272851)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- selection signals, fine wool, coarse wool, candidate genes, whole-genome resequencing, FST, XP-EHH, LGR4, PIK3CA, SEMA3C, NFIB, OPHN1, THADA, inositol phosphate metabolism, axon guidance, focal adhesions, gene ontology enrichment, KEGG pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
