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The Diversification of Plant NBS-LRR Defense Genes Directs the Evolution of MicroRNAs That Target Them
Open accessAbstract
High expression of plant nucleotide binding site leucine-rich repeat (NBS-LRR) defense genes is often lethal to plant cells, a phenotype perhaps associated with fitness costs. Plants implement several mechanisms to control the transcript level of NBS-LRR defense genes. As negative transcriptional regulators, diverse miRNAs target NBS-LRRs in eudicots and gymnosperms. To understand the evolutionary benefits of this miRNA-NBS-LRR regulatory system, we investigated the NBS-LRRs of 70 land plants, coupling this analysis with extensive small RNA data. A tight association between the diversity of NBS-LRRs and miRNAs was found. The miRNAs typically target highly duplicated NBS-LRRs In comparison, families of heterogeneous NBS-LRRs were rarely targeted by miRNAs in Poaceae and Brassicaceae genomes. We observed that duplicated NBS-LRRs from different gene families periodically gave birth to new miRNAs. Most of these newly emerged miRNAs target the same conserved, encoded protein motif of NBS-LRRs, consistent with a model of convergent evolution for these miRNAs. By assessing the interactions between miRNAs and NBS-LRRs, we found nucleotide diversity in the wobble position of the codons in the target site drives the diversification of miRNAs. Taken together, we propose a co-evolutionary model of plant NBS-LRRs and miRNAs hypothesizing how plants balance the benefits and costs of NBS-LRR defense genes.
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OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Li, L., Stoeckert, C. J., & Roos, D. S. (2003) · Genome Research · doi:10.1101/gr.1224503 · Cited by 5,707
miRBase: annotating high confidence microRNAs using deep sequencing data
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The role of site accessibility in microRNA target recognition
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460
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Axtell, M. J., & Meyers, B. C. (2018) · The Plant Cell · doi:10.1105/tpc.17.00851 · Cited by 429
Self-citationA Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors
Lapin, D., Kovacova, V., Sun, X., Dongus, J. A., Bhandari, D., von Born, P., Bautor, J., Guarneri, N., Rzemieniewski, J., Stuttmann, J., et al. (2019) · The Plant Cell · doi:10.1105/tpc.19.00118 · Cited by 303
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Metadata
- Authors
- Zhang, Y., Xia, R., Kuang, H., & Meyers, B. C.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-08-10
- Volume
- 33
- Issue
- 10
- Pages
- 2692-2705
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2484850092
- Cited by
- 186
- References
- 4
- FWCI
- 25.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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