Regulation of HOXA-10 and its expression in normal and abnormal endometrium
Abstract
HOXA-10 is a member of a family of genes that serve as transcription factors during development and have been shown to be important for uterine function. Using immunohistochemistry and RNAse protection assays (RPA), HOXA-10 was shown to be expressed in both epithelial and stromal cells with increased expression during the window of implantation. By in-vitro culture of isolated endometrial epithelium or stroma, HOXA-10, expression was increased after treatment with oestradiol (10(-8) mol/l) with or without progesterone (10(-6) mol/l). In stromal cells, oestradiol and progesterone both appeared to increase HOXA-10 expression and were additive. Relaxin (30 ng/ml) appeared to further increase stromal HOXA-10 expression. HOXA-10 expression during the window of implantation was compared in normal menstrual cycles to endometrium from women with endometriosis and suspected defects in uterine receptivity. Little or no difference was seen in luminal, glandular or endothelial HOXA-10 expression but a significant reduction in stroma HOXA-10 expression was noted in women with endometriosis. In conclusion, HOXA-10 is a hormone-regulated endometrial transcription factor that appears to be responsive to both ovarian steroids and relaxin. The appearance of this nuclear protein during the window of implantation in epithelium and stroma may offer new insight into the regulation of uterine receptivity and assist in the identification of other genes that are critical to the establishment of a successful pregnancy.
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The endometrium of women with endometriosis responds differently to ovarian hormones.
“It is important to emphasize that the endometrium of women with endometriosis has been documented to respond differently to ovarian hormones (83-86), and we can use this fact to discover new potential biomarkers through minimally invasive means (87).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [83]
Cites
A gene complex controlling segmentation in Drosophila
Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813 · see citing works
Rw, N., Hertig, A. T., & Rock, J. A. (1950) · Fertility and Sterility · doi:10.1016/s0015-0282(16)30062-0 · Cited by 2,854 · see citing works
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
Stewart, C. L., Kašpar, P., Brunet, L. J., Bhatt, H., Gadi, I. K., Köntgen, F., & Abbondanzo, S. J. (1992) · Nature · doi:10.1038/359076a0 · Cited by 2,033 · see citing works
Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice
Lim, H. J., Paria, B. C., Das, S., Dinchuk, J. E., Langenbach, R. I., Trzăskos, J. M., & Dey, S. K. (1997) · Cell · doi:10.1016/s0092-8674(00)80402-x · Cited by 1,426 · see citing works
Homeo Boxes in the Study of Development
Gehring, W. J. (1987) · Science · doi:10.1126/science.2884726 · Cited by 899 · see citing works
A description of 34 human ova within the first 17 days of development
Hertig, A. T., Rock, J. A., & Adams, E. C. (1956) · American Journal of Anatomy · doi:10.1002/aja.1000980306 · Cited by 654 · see citing works
Lessey, B. A., Killam, A. P., METZGER, D. A., Haney, A. F., Greene, G. L., & McCarty, K. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-334 · Cited by 647 · see citing works
Self-citationLessey, B. A., Damjanovich, L., Coutifaris, C., Castelbaum, A. J., Albelda, S. Μ., & Buck, C. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115835 · Cited by 640 · see citing works
Self-citationDas, S., Wang, X., Paria, B. C., Damm, D. L., Abraham, J. A., Klagsbrun, M., Andrews, G. K., & Dey, S. K. (1994) · Development · doi:10.1242/dev.120.5.1071 · Cited by 568 · see citing works
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium
Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J. R., Korach, K. S., Taylor, J., Lubahn, D. B., & Cunha, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6535 · Cited by 556 · see citing works
Sexually dimorphic sterility phenotypes in HoxalO-deficient mice
Satokata, I., Benson, G., & Maas, R. L. (1995) · Nature · doi:10.1038/374460a0 · Cited by 519 · see citing works
Aberrant integrin expression in the endometrium of women with endometriosis
Lessey, B. A., Castelbaum, A. J., Sawin, S. W., Buck, C. A., Schinnar, R., Bilker, W. B., & Strom, B. L. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.7519194 · Cited by 514 · see citing works
Self-citationBenson, G. V., Lim, H. J., Paria, B. C., Satokata, I., Dey, S. K., & Maas, R. L. (1996) · Development · doi:10.1242/dev.122.9.2687 · Cited by 501 · see citing works
Cullinan, E. B., Abbondanzo, S. J., Anderson, P. S., Pollard, J. W., Lessey, B. A., & Stewart, C. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3115 · Cited by 431 · see citing works
Self-citationTaylor, H. S., Arici, A. M., Olive, D. L., & Igarashi, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1597 · Cited by 420 · see citing works
Integrins as markers of uterine receptivity in women with primary unexplained infertility
Lessey, B. A., Castelbaum, A. J., Sawin, S. W., et al. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57422-6 · Cited by 402 · see citing works
Self-citationFurther characterization of endometrial integrins during the menstrual cycle and in pregnancy
Lessey, B. A., Castelbaum, A. J., Buck, C. A., Lei, Y., Yowell, C. W., & Sun, J. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56937-4 · Cited by 391 · see citing works
Self-citationBudwit-Novotny, D. A., McCarty, K. S., Cox, E. B., et al. (1986) · PubMed · Cited by 381 · see citing works
Chakraborty, I., Das, S. K., Wang, J., & Dey, S. K. (1996) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0160107 · Cited by 337 · see citing works
The impact of embryonic development and endometrial maturity on the timing of implantation
Bergh, P. A., & Navot, D. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55259-5 · Cited by 328 · see citing works
Ma, L., Benson, G. V., Lim, H. J., Dey, S. K., & Maas, R. L. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8907 · Cited by 299 · see citing works
Hydrosalpinges adversely affect markers of endometrial receptivity
Meyer, W. R., Castelbaum, A. J., Somkuti, S. G., Sagoskin, A. W., Doyle, M. B., Harris, J. E., & Lessey, B. A. (1997) · Human Reproduction · doi:10.1093/humrep/12.7.1393 · Cited by 281 · see citing works
Self-citationUse of Immunocytochemistry of Progesterone and Estrogen Receptors for Endometrial Dating
García, E., Bouchard, P., de Brux, J., Berdah, J., Frydman, R., SCHAISON, G., Milgröm, E., & Perrot‐Applanat, M. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-1-80 · Cited by 248 · see citing works
Developmental functions of mammalian Hox genes
Favier, B. (1997) · Molecular Human Reproduction · doi:10.1093/molehr/3.2.115 · Cited by 239 · see citing works
Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation
Lessey, B. A., Yeh, I.-T., Castelbaum, A. J., et al. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58140-0 · Cited by 216 · see citing works
Self-citationHUANG, J. R., Tseng, L., BISCHOF, P., & Jänne, O. A. (1987) · Endocrinology · doi:10.1210/endo-121-6-2011 · Cited by 197 · see citing works
Patterns of expression of integrin molecules in human endometrium throughout the menstrual cycle
TABIBZADEH, S. S. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137753 · Cited by 187 · see citing works
Fukuda, M., Sato, T., Nakayama, J., et al. (1995) · Genes & Development · doi:10.1101/gad.9.10.1199 · Cited by 180 · see citing works
Press, M. F., Udove, J. A., & Greene, G. L. (1988) · PubMed Central · Cited by 142 · see citing works
Preimplantation development of the mammalian embryo and its regulation by growth factors
Stewart, C. L., & Cullinan, E. B. (1997) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1997)21:1 · Cited by 136 · see citing works
Taylor, H. S., Arici, A. M., Olive, D. L., & Igarashi, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1057 · Cited by 131 · see citing works
Lessey, B. A., Ilesanmi, A. O., Castelbaum, A. J., et al. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00103-3 · Cited by 123 · see citing works
Self-citationZhu, L.-J., Bagchi, M. K., & Bagchi, I. C. (1998) · Endocrinology · doi:10.1210/endo.139.1.5707 · Cited by 120 · see citing works
Hild-Petito, S. A., Fazleabas, A. T., Julian, J. A., et al. (1996) · Biology of Reproduction · doi:10.1095/biolreprod54.5.939 · Cited by 111 · see citing works
Kumar, S., Zhu, L.-J., Polihronis, M., Cameron, S. T., Baird, D. T., Schatz, F., Dua, A., Ying, Y.-K., Bagchi, M. K., & Bagchi, I. C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5328 · Cited by 109 · see citing works
Somkuti, S. G., Yuan, L., Fritz, M. A., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4102 · Cited by 85 · see citing works
Self-citationAlbers, A., Thie, M., Hohn, H.-P., et al. (1995) · Cells Tissues Organs · doi:10.1159/000147710 · Cited by 72 · see citing works
Immunohistochemical markers of uterine receptivity in the human endometrium
Ilesanmi, A. O., Hawkins, D. A., & Lessey, B. A. (1993) · Microscopy Research and Technique · doi:10.1002/jemt.1070250304 · Cited by 63 · see citing works
Self-citationSomkuti, S. G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2192 · Cited by 61 · see citing works
REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR SENESCENCE
Wynford‐Thomas, D. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199610)180:2 · Cited by 59 · see citing works
Zhu, L.-J. (1998) · Endocrinology · doi:10.1210/en.139.1.330 · Cited by 49 · see citing works
Integrins and the Endometrium: New Markers of Uterine Receptivity
Lessey, B. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48529.x · Cited by 34 · see citing works
Self-citationSeppälä, M. T., & Tiitinen, A. E. (1995) · Human Reproduction · doi:10.1093/humrep/10.suppl_2.67 · Cited by 28 · see citing works
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Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328 · see citing works
Wu, Y., Halverson, G., Basir, Z., Strawn, E., Yan, P., & Guo, S.-W. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.01.034 · Cited by 283 · see citing works
Leyendecker, G., Bilgicyildirim, A., Inacker, M., Stalf, T., Huppert, P., Mall, G., Böttcher, B., & Wildt, L. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3437-8 · Cited by 261 · see citing works
Biomarkers in endometriosis: Challenges and opportunities
Ahn, S. H., Singh, V., & Tayade, C. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.009 · Cited by 242 · see citing works
Rackow, B. W., & Taylor, H. S. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.029 · Cited by 239 · see citing works
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Kim, J. J., Taylor, H. S., Lu, Z., Ladhani, O., Hastings, J. M., Jackson, K. S., Wu, Y., Guo, S. W., & Fazleabas, A. T. (2007) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gam005 · Cited by 228 · see citing works
Lee, B., Du, H., & Taylor, H. S. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.070391 · Cited by 204 · see citing works
HOXA10 expression is decreased in endometrium of women with adenomyosis
Fischer, C. P., Kayisili, U., & Taylor, H. S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.09.060 · Cited by 133 · see citing works
DNA methylation in endometriosis (Review)
KOUKOURA, O., SIFAKIS, S., & SPANDIDOS, D. A. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4925 · Cited by 103 · see citing works
Izawa, M., Taniguchi, F., Uegaki, T., Takai, E., Iwabe, T., Terakawa, N., & Harada, T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.06.024 · Cited by 73 · see citing works
van Kaam, K. J. A. F., Delvoux, B., Romano, A., D’Hooghe, T., Dunselman, G. A. J., & Groothuis, P. G. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.031 · Cited by 64 · see citing works
FKBP4 is regulated by HOXA10 during decidualization and in endometriosis
Yang, H., Zhou, Y., Edelshain, B., Schatz, F., Lockwood, C. J., & Taylor, H. S. (2012) · Reproduction · doi:10.1530/rep-11-0438 · Cited by 63 · see citing works
- Authors
- Gui, Y., Zhang, J., Yuan, L., & Lessey, B. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- MHR: Basic science of reproductive medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09
- Volume
- 5
- Issue
- 9
- Pages
- 866-873
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- OpenAlex
- W2144684054
- Cited by
- 139
- References
- 43
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 2 · 2012: 5
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01hd034824-04)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-34824, U54HD035041, HD35041)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- HOXA10, endometrium, endometriosis, endometrial receptivity, implantation window, estradiol, progesterone, relaxin, endometrial stroma, endometrial epithelium, transcription factors, pregnancy establishment
- MeSH terms
- Fulvestrant, Homeobox A10 Proteins, Cells, Cultured, DNA-Binding Proteins, Dose-Response Relationship, Drug, Endometriosis, Endometrium, Estradiol, Estrogen Antagonists, Female, Hormone Antagonists, Humans, Menstrual Cycle, Embryo Implantation, Progesterone, Reference Values, Relaxin, Mifepristone, Stromal Cells, Homeodomain Proteins
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