The DOI matches its Crossref record.
Mitochondrial DNA content affects the fertilizability of human oocytes
Abstract
Mitochondrial DNA content varies considerably in oocytes, even when collected from the same patient. In the present study, real-time quantitative polymerase chain reaction analysis of 113 unfertilized oocytes obtained from 43 patients revealed an average of 193,000 (range: 20,000 to 598,000) mitochondrial genomes per cell. We compared several groups of oocytes to investigate the relationship between mitochondrial DNA content and fertilizability. The average mitochondrial DNA copy number was significantly lower in cohorts suffering from fertilization failure compared to cohorts with a normal rate of fertilization. In addition, the mitochondrial copy number of oocytes from patients with fertilization failure due to unknown causes was significantly lower than that of oocytes from patients in which IVF failure was due mainly to a severe sperm defect. The lower mtDNA copy number could be due to defective cytoplasmic maturation of oocytes. We conclude that low mitochondrial DNA content, due to inadequate mitochondrial biogenesis or cytoplasmic maturation, may adversely affect oocyte fertilizability.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mitochondria in health and disease: perspectives on a new mitochondrial biology
Duchen, M. R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.03.001 · Cited by 721
Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine
Wallace, D. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.081205.150955 · Cited by 363
Mitochondria directly influence fertilisation outcome in the pig
El Shourbagy, S. H., Spikings, E. C., Freitas, M., & St John, J. C. (2006) · Reproduction · doi:10.1530/rep.1.00551 · Cited by 320
Aging and the environment affect gamete and embryo potential: can we intervene?
Meldrum, D. R., Casper, R. F., Diez-Juan, A., Simon, C., Domar, A. D., & Frydman, R. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.01.013 · Cited by 159
Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies
Igarashi, H., Takahashi, T., & Nagase, S. (2015) · Reproductive Medicine and Biology · doi:10.1007/s12522-015-0209-5 · Cited by 116
Metadata
- Authors
- Reynier, P., May-Panloup, P., Chretien, M.-F., Morgan, C. J., Jean, M., Savagner, F., Barriere, P., & Malthiery, Y.
- Venue
- Molecular Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05-01
- Volume
- 7
- Issue
- 5
- Pages
- 425-429
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- OpenAlex
- W2134728059
- Cited by
- 523
- References
- 0
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mitochondrial DNA content affects the fertilizability of human oocytes. https://app.cochat.ai/papers/10.1093/molehr/7.5.425
- The paper
- Reynier, P., May-Panloup, P., Chretien, M.-F., Morgan, C. J., Jean, M., Savagner, F., Barriere, P., & Malthiery, Y. (2001). Mitochondrial DNA content affects the fertilizability of human oocytes. Molecular Human Reproduction. https://doi.org/10.1093/molehr/7.5.425
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
