Cited by 159Reproductive Biology and FertilityReproductive Health and TechnologiesOvarian function and disorders

Aging and the environment affect gamete and embryo potential: can we intervene?

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Meldrum, David R., Casper, Robert F., Diez-Juan, Antonio, Simon, Carlos, Domar, Alice D., Frydman, Rene·2016·Fertility and Sterility

Abstract

Optimal maturation of the oocyte depends on its environment and determines embryo competence, because the embryonic genome is not active until the cleavage stage and new mitochondria are not produced until blastulation. Adverse environmental factors include aging, andropause, oxidative stress, obesity, smoking, alcohol, and psychologic stress, whereas androgen supplementation, a prudent diet, exercise, nutritional supplements, and psychologic interventions have beneficial effects. Mitochondrial function and energy production deteriorate with age, adversely affecting ovarian reserve, chromosome segregation, and embryo competence. In aging mice, the mitochondrial cofactor coenzyme Q10 reverses most of these changes. Early human experience has been encouraging, although only a small study using a shorter duration of intervention compared with the murine model has been carried out. Mitochondrial metabolic stress can result in an abnormal compensatory increase in mitochondrial DNA, which can be assessed in biopsied blastomeres of trophectoderm as a predictive biomarker of implantation failure. Psychologic stress may reduce oocyte competence by shifting blood flow away from the ovary as part of the classic "fight or flight" physiologic response, and methods to reduce stress or the body's reaction to stress improve pregnancy success. Enhancing oocyte competence is a key intervention that promises to reduce the number of euploid embryos failing to produce viable deliveries.

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Crossref · 10.1016/j.fertnstert.2016.01.013

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  • It is well-established that obesity is related to menstrual disorders, infertility, miscarriage, obstetric complications, live birth rate and can affect the success of assisted reproductive technology.

    “It is well-established that obesity is related to menstrual disorders, infertility, miscarriage, obstetric complications, live birth rate and can affect the success of assisted reproductive technology.29–32”

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Authors
Meldrum, D. R., Casper, R. F., Diez-Juan, A., Simon, C., Domar, A. D., & Frydman, R.
Affiliations
  • University of California San Diego (US)
  • Mount Sinai Hospital (CA)
  • Beth Israel Deaconess Medical Center (US)
  • Hôpital Foch (FR)
Corresponding author
Meldrum, David R.
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2016-03
Volume
105
Issue
3
Pages
548-559
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2271112859
Cited by
159
References
138
Citations by year
2026: 6 · 2025: 13 · 2024: 11 · 2023: 11 · 2022: 17 · 2021: 21 · 2020: 19 · 2019: 16 · 2018: 19 · 2017: 20 · 2016: 6
FWCI
3.01
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
oocyte aging, oocyte developmental competence, embryo developmental competence, mitochondrial function, oxidative stress, andropause, obesity, smoking, psychological stress, coenzyme Q10, mitochondrial DNA copy number, implantation failure, ovarian reserve, androgen supplementation, diet and exercise, dietary supplements, stress reduction intervention
MeSH terms
Maternal Health, Age Factors, Aging, Animals, Blastocyst, DNA, Mitochondrial, Embryo Transfer, Energy Metabolism, Environment, Female, Fertility, Fertilization in Vitro, Infertility, Life Style, Male, Mitochondria, Oocytes, Pregnancy, Risk Factors, Spermatozoa, Stress, Physiological, Stress, Psychological, Treatment Outcome, Reproductive Techniques, Assisted, Risk Reduction Behavior, Oocyte Retrieval

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