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Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization

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In vitro culture of human blastocysts

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Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics

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Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study

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Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage

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Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos

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Incidence and spectrum of chromosome abnormalities in spontaneous abortions: New insights from a 12-year study

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The origin and impact of embryonic aneuploidy

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SNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts

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Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality

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Embryo morphology and development are dependent on the chromosomal complement

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Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation

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Chromosome abnormalities and their relationship to morphology and development of human embryos

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X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos

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Elevated Sperm Chromosome Aneuploidy and Apoptosis in Patients With Unexplained Recurrent Pregnancy Loss

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Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure

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A Y-chromosomal effect on blastocyst cell number in mice

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Incidence of Chromosomal Abnormalities from a Morphologically Normal Cohort of Embryos in Poor-Prognosis Patients

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Aneuploidy in the Human Blastocyst

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Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics

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Impact of chromosomal abnormalities on preimplantation embryo development

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Time-lapse microscopy and image analysis in basic and clinical embryo development research

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Human embryonic development after blastomere removal: a time-lapse analysis

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Evolution of aneuploidy up to Day 4 of human preimplantation development

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Trophectoderm morphology significantly affects the rates of ongoing pregnancy and miscarriage in frozen-thawed single-blastocyst transfer cycle in vitro fertilization

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Use of array comparative genomic hybridization (array-CGH) for embryo assessment: clinical results

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Day-3 embryo morphology predicts euploidy among older subjects

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Oocyte euploidy, pronuclear zygote morphology and embryo chromosomal complement

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Could Sperm Aneuploidy Rate Determination Be Used as a Predictive Test Before Intracytoplasmic Sperm Injection?

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Assessment of day-3 morphology and euploidy for individual chromosomes in embryos that develop to the blastocyst stage

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Routine morphological scoring systems in assisted reproduction treatment fail to reflect age-related impairment of oocyte and embryo quality

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False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3

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The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans

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Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study

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Mosaicism in health and disease — clones picking up speed

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Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos

Alanis-Lobato, G., Zohren, J., McCarthy, A., Fogarty, N. M. E., Kubikova, N., Hardman, E., Greco, M., Wells, D., Turner, J. M. A., & Niakan, K. K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004832117 · Cited by 234 · see citing works

Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and ‘OMICS’: is looking good still important?

Gardner, D. K., & Balaban, B. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw057 · Cited by 234 · see citing works

Paternal factors contributing to embryo quality

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Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis

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Embryos with morphokinetic abnormalities may develop into euploid blastocysts

Lagalla, C., Tarozzi, N., Sciajno, R., Wells, D., Santo, M., Nadalini, M., Distratis, V., & Borini, A. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.11.008 · Cited by 147 · see citing works

Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers

Ravichandran, K., McCaffrey, C., GRIFO, J. A., Morales, A. J., Perloe, M., Munné, S., Wells, D., & Fragouli, E. (2017) · Human Reproduction · doi:10.1093/humrep/dex070 · Cited by 123 · see citing works

The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies

Fragouli, E., Munné, S., & Wells, D. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy036 · Cited by 120 · see citing works

Should we be promoting embryo transfer at blastocyst stage?

Maheshwari, A., Hamilton, M., & Bhattacharya, S. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.09.016 · Cited by 119 · see citing works

Mitochondrial DNA in Day 3 embryo culture medium is a novel, non-invasive biomarker of blastocyst potential and implantation outcome

Stigliani, S., Persico, L., Lagazio, C., Anserini, P., Venturini, P. L., & Scaruffi, P. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gau086 · Cited by 103 · see citing works

Morphological and morphokinetic associations with aneuploidy: a systematic review and meta-analysis

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Type of chromosome abnormality affects embryo morphology dynamics

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High Aneuploidy Rates Observed in Embryos Derived from Donated Oocytes are Related to Male Aging and High Percentages of Sperm DNA Fragmentation

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Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment: A Pilot Study

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Variables associated with mitochondrial copy number in human blastocysts: what can we learn from trophectoderm biopsies?

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Cleavage pattern predicts developmental potential of day 3 human embryos produced by IVF

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Human embryo mosaicism: did we drop the ball on chromosomal testing?

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Deoxyribonucleic acid detection in blastocoelic fluid: a new predictor of embryo ploidy and viable pregnancy

Magli, M. C., Albanese, C., Crippa, A., Tabanelli, C., Ferraretti, A. P., & Gianaroli, L. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.09.016 · Cited by 68 · see citing works

Extracellular vesicle-mediated delivery of molecular compounds into gametes and embryos: learning from nature

Barkalina, N., Jones, C., Wood, M. J. A., & Coward, K. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv027 · Cited by 63 · see citing works

Relationship Between Morphology, Euploidy and Implantation Potential of Cleavage and Blastocyst Stage Embryos.

Majumdar, G., Majumdar, A., Verma, I. C., & Upadhyaya, K. C. (2017) · Europe PMC (PubMed Central) · doi:10.4103/0974-1208.204013 · Cited by 63 · see citing works

Blastocyst score, a blastocyst quality ranking tool, is a predictor of blastocyst ploidy and implantation potential

Zhan, Q., Sierra, E., Malmsten, J. E., Ye, Z., Rosenwaks, Z., & Zaninović, N. (2020) · F&S Reports · doi:10.1016/j.xfre.2020.05.004 · Cited by 61 · see citing works

Alternative patterns of partial embryo compaction: prevalence, morphokinetic history and possible implications

Lagalla, C., Coticchio, G., Sciajno, R., Tarozzi, N., Zacà, C., & Borini, A. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2019.11.011 · Cited by 52 · see citing works

Association between growth dynamics, morphological parameters, the chromosomal status of the blastocysts, and clinical outcomes in IVF PGS cycles with single embryo transfer

Barash, O. O., Ivani, K. A., Willman, S. P., Rosenbluth, E. M., Wachs, D. S., Hinckley, M. D., Pittenger, S. R., & Weckstein, L. N. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-0944-0 · Cited by 50 · see citing works

Recent advances in preimplantation genetic diagnosis and screening

Lu, L., Lv, B., Huang, K. Y., Xue, Z., Zhu, X., & Fan, G. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0750-0 · Cited by 47 · see citing works

Abnormal cleavage and developmental arrest of human preimplantation embryos in vitro

McCollin, A., Swann, R. L., Summers, M. C., Handyside, A. H., & Ottolini, C. S. (2019) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2019.04.008 · Cited by 46 · see citing works

Oocyte quality and embryo selection strategies: a review for the embryologists, by the embryologists

Anagnostopoulou, C., Rosas, I. M., SINGH, N., GUGNANI, N., CHOCKALINGHAM, A., SINGH, K., DESAI, D., Darbandi, M., MANOHARAN, M., Darbandi, S., et al. (2022) · Panminerva Medica · doi:10.23736/s0031-0808.22.04680-8 · Cited by 45 · see citing works

Euploidy in relation to blastocyst sex and morphology

Wang, A., Kort, J., Behr, B. R., & Westphal, L. M. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1262-x · Cited by 44 · see citing works

Increased pregnancy outcome after day 5 versus day 6 transfers of human vitrified-warmed blastocysts

Sciorio, R., Thong, K. J., & Pickering, S. J. (2019) · Zygote · doi:10.1017/s0967199419000273 · Cited by 42 · see citing works

High percentages of embryos with 21, 18 or 13 trisomy are related to advanced paternal age in donor egg cycles

García-Ferreyra, J., Hilario, R., & Dueñas, J. (2018) · JBRA · doi:10.5935/1518-0557.20180004 · Cited by 41 · see citing works

Male factor infertility impacts the rate of mosaic blastocysts in cycles of preimplantation genetic testing for aneuploidy

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The paternal toolbox for embryo development and health

Tarozzi, N., Nadalini, M., Coticchio, G., Zacà, C., Lagalla, C., & Borini, A. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab042 · Cited by 40 · see citing works

Should we transfer poor quality embryos?

Kirillova, A., Lysenkov, S. N., Farmakovskaya, M., Kiseleva, Y., Martazanova, B., Mishieva, N., Abubakirov, A., & Sukhikh, G. T. (2020) · Fertility Research and Practice · doi:10.1186/s40738-020-00072-5 · Cited by 39 · see citing works

Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?

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Elective single blastocyst transfer in advanced maternal age

Tannus, S., Son, W., & Dahan, M. H. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-0906-6 · Cited by 38 · see citing works

Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in vitro fertilization cycles

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When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation

Lacconi, V., Massimiani, M., Carriero, I., Bianco, C., Ticconi, C., Pavone, V., Alteri, A., Muzii, L., Rago, R., Pisaturo, V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052834 · Cited by 36 · see citing works

No advantage of fresh blastocyst versus cleavage stage embryo transfer in women under the age of 39: a randomized controlled study

Levi-Setti, P. E., Cirillo, F., Smeraldi, A., Morenghi, E., Mulazzani, G., & Albani, E. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-1092-2 · Cited by 36 · see citing works

Deep learning neural network analysis of human blastocyst expansion from time-lapse image files

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Blasts from the past: is morphology useful in PGT-A tested and untested frozen embryo transfers?

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Blastocyst Morphology Based on Uniform Time-Point Assessments is Correlated With Mosaic Levels in Embryos

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Using Time Lapse Monitoring for Determination of Morphological Defect Frequency in Feline Embryos after in Vitro Fertilization (IVF)

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Mitochondrial DNA in Fresh versus Frozen Embryo Culture Media of Polycystic Ovarian Syndrome Patients Undergoing Invitro Fertilization: A Possible Predictive Marker of a Successful Pregnancy

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Role of Artificial Intelligence in Quality Assurance in ART: A Review

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EDITORIAL Obscure effect of aneuploidy on embryo morphology

Geraedts, J. P. M. (2016)

Obscure effect of aneuploidy on embryo morphology

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