A Y-chromosomal effect on blastocyst cell number in mice
Abstract
Karyotypic and cell number analysis of 3.5 day post coitum preimplantation mouse embryos was used to determine whether XY embryos had more cells than XX embryos at the late morula/early blastocyst stage. This proved to be the case for the CD1 strain (for which it had previously been shown that XY embryos form a blastocoel earlier than XX embryos) and for the MF1 strain. However, this increased cell number was not seen in MF1 embryos carrying an RIII strain Y in place of the MF1 Y. Furthermore, interstrain crosses between CD1 and the MF1,YRIII strain showed that the cell number increase segregated with the CD1 Y but not with the RIII Y. It is concluded that the CD1 and MF1 Y chromosomes carry a factor that accelerates the rate of preimplantation development.
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The Y chromosome is known to accelerate cellular glucose metabolism and growth.
“For example, the Y chromosome is known to accelerate cellular glucose metabolism and growth [72].”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [72]
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Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626 · see citing works
Arnold, A. P., & Chen, X. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.001 · Cited by 587 · see citing works
Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos
Fragouli, E., Alfarawati, S., Spath, K., & Wells, D. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gat073 · Cited by 189 · see citing works
The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse
Burgoyne, P. S., Thornhill, A. R., Boudrean, S. K., Darling, S. M., Bishop, C. E., & Evans, E. P. (1995) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1995.0159 · Cited by 168 · see citing works
Self-citationBurgoyne, P. S., & Arnold, A. P. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0115-5 · Cited by 154 · see citing works
Self-citation
- Authors
- Burgoyne, P. S.
- Affiliations
- MRC Mammalian Development Unit, Wolfson House, 4 Stephenson Way, London NWl 2HE, UK
- Corresponding author
- Burgoyne, Paul S.
- ORCID
- Burgoyne, Paul S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1993-01-01
- Volume
- 117
- Issue
- 1
- Pages
- 341-345
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2151047556
- Cited by
- 160
- References
- 0
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Y chromosome, blastocyst cell number, preimplantation embryo development, blastocoel formation, sex chromosome segregation, mouse embryo
- MeSH terms
- Animals, Blastocyst, Breeding, Cell Count, Chromosomes, Female, Embryonic and Fetal Development, Karyotyping, Mice, Inbred Strains, Pregnancy, Y Chromosome, Embryonic Development, Mice
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