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Chemistry and biology of ferritin
Open accessAbstract
Iron is an essential element required by cells and has been described as a key player in ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming multimeric assemblies with crystalline iron cores. We discuss the latest findings on ferritin structure and activity and its link to cell metabolism and ferroptosis. The chemistry of iron, including its oxidation states, is important for its biological functions, its reactivity, and the biology of ferritin. Ferritin can be localized in different cellular compartments and secreted by cells with a variety of functions depending on its spatial context. Here, we discuss how cellular ferritin localization is tightly linked to its function in a tissue-specific manner, and how impairment of iron homeostasis is implicated in diseases, including cancer and coronavirus disease 2019. Ferritin is a potential biomarker and we discuss latest research where it has been employed for imaging purposes and drug delivery.
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“At a steady state, the serum ferritin (SF) concentration reasonably reflects the total body iron stores.”
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Metadata
- Authors
- Plays, M., Müller, S., & Rodriguez, R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-04-21
- Volume
- 13
- Issue
- 5
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- PMC
- PMC8083198
- OpenAlex
- W3154029091
- Cited by
- 232
- References
- 217
- Citations by year
- 2026: 42 · 2025: 63 · 2024: 48 · 2023: 41 · 2022: 32 · 2021: 6
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Metallomics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- European Research Council
- Horizon 2020 Framework Programme (647973)
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- ferritin, iron storage, ferroptosis, iron oxidation state, iron homeostasis, cancer, COVID-19 pandemic, biomarkers, imaging, drug delivery
- MeSH terms
- Ferroptosis, COVID-19, SARS-CoV-2, Biotechnology, Ceruloplasmin, Ferritins, Glycosylation, Homeostasis, Humans, Inflammation, Iron, Neoplasms, Prognosis, Tissue Distribution, Biomarkers, Drug Delivery Systems, Nanotechnology
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