Chemistry and biology of ferritin

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature · doi:10.1038/nature24297 · Cited by 1,799

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667

Diabetes is a risk factor for the progression and prognosis of COVID‐19

Guo, W., Li, M., Dong, Y., Zhou, H., Zhang, Z., Tian, C., Qin, R., Wang, H., Shen, Y., Du, K., et al. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3319 · Cited by 1,404

Epigenetic plasticity and the hallmarks of cancer

Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340

The chemical basis of ferroptosis

Conrad, M., & Pratt, D. A. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0408-1 · Cited by 1,047

Serum ferritin: Past, present and future

Wang, W., Knovich, M. A., Coffman, L. G., Torti, F. M., & Torti, S. V. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.03.011 · Cited by 913

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Park, E., & Chung, S. W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2064-5 · Cited by 902

Ferritins: A family of molecules for iron storage, antioxidation and more

Arosio, P., Ingrassia, R., & Cavadini, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.004 · Cited by 886

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

Kell, D. B., & Pretorius, E. (2014) · Metallomics · doi:10.1039/c3mt00347g · Cited by 667

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Mai, T. T., Hamaï, A., Hienzsch, A., Cañeque, T., Müller, S., Wicinski, J., Cabaud, O., Leroy, C., David, A., Acevedo, V., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2778 · Cited by 621

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Brown, C. W., Amante, J. J., Chhoy, P., Elaimy, A. L., Liu, H., Zhu, L. J., Baer, C. E., Dixon, S. J., & Mercurio, A. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.10.007 · Cited by 589

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Yoshida, M., Minagawa, S., Araya, J., Sakamoto, T., Hara, H., Tsubouchi, K., Hosaka, Y., Ichikawa, A., Saito, N., Kadota, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10991-7 · Cited by 572

Laboratory diagnosis of iron-deficiency anemia: An overview

Guyatt, G. H., Oxman, A. D., Ali, M., Willan, A., McIlroy, W., & Patterson, C. (1992) · Journal of General Internal Medicine · doi:10.1007/bf02598003 · Cited by 564

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

Li, L., Fang, C. J., Ryan, J. C., Niemi, E. C., Lebrón, J. A., Björkman, P. J., Arase, H., Torti, F. M., Torti, S. V., Nakamura, M. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913192107 · Cited by 558

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

Mancias, J. D., Pontano Vaites, L., Nissim, S., Biancur, D. E., Kim, A. J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A. C., & Harper, J. W. (2015) · eLife · doi:10.7554/elife.10308 · Cited by 552

A cytosolic iron chaperone that delivers iron to ferritin

Shi, H., Bencze, K. Z., Stemmler, T. L., & Philpott, C. C. (2008) · Science · doi:10.1126/science.1157643 · Cited by 536

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

Chen, G., Benthani, F. A., Wu, J., Liang, D., Bian, Z., & Jiang, X. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0352-3 · Cited by 518

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

Eaton, J. K., Furst, L., Ruberto, R. A., Moosmayer, D., Hilpmann, A., Ryan, M. J., Zimmermann, K. C., Cai, L. L., Niehues, M., Badock, V., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0501-5 · Cited by 518

Ferritin, cellular iron storage and regulation

Arosio, P., Elia, L., & Poli, M. (2017) · IUBMB Life · doi:10.1002/iub.1621 · Cited by 480

Iron addiction: a novel therapeutic target in ovarian cancer

Basuli, D., Tesfay, L., Deng, Z., Paul, B., Yamamoto, Y., Ning, G., Xian, W., McKeon, F., Lynch, M. L., Crum, C. P., et al. (2017) · Oncogene · doi:10.1038/onc.2017.11 · Cited by 469

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

Connor, J. R., Menzies, S. L., Martin, S. M. S., & Mufson, E. J. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490310111 · Cited by 468

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

Cohen, L. A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.-L., Crooks, D. R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M. W., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253815 · Cited by 452

Brain iron and ferritin in Parkinson’s and Alzheimer’s diseases

Jellinger, K., Paulus, W., Grundke-Iqbal, I., Riederer, P., & Youdim, M. B. H. (1990) · Journal of Neural Transmission - Parkinson's Disease and Dementia Section · doi:10.1007/bf02252926 · Cited by 445

Iron and Cancer

Torti, S. V., Manz, D. H., Paul, B. T., Blanchette-Farra, N., & Torti, F. M. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051732 · Cited by 426

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

Fuhrmann, D. C., Mondorf, A. W., Beifuß, J., Jung, M., & Brüne, B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101670 · Cited by 415

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Cheng, L., Li, H., Li, L., Liu, C., Yan, S., Chen, H., & Li, Y. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23618 · Cited by 413

The role of NCOA4-mediated ferritinophagy in health and disease

Santana-Codina, N., & Mancias, J. D. (2018) · Pharmaceuticals · doi:10.3390/ph11040114 · Cited by 410

Ferritin: A Versatile Building Block for Bionanotechnology

Jutz, G., van Rijn, P., de Miranda, B. S., & Böker, A. (2015) · Chemical Reviews · doi:10.1021/cr400011b · Cited by 407

Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery

Li, J. Y., Paragas, N., Ned, R. M., Qiu, A., Viltard, M., Leete, T., Drexler, I. R., Chen, X., Sanna‐Cherchi, S., Mohammed, F., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.002 · Cited by 366

Global transcriptome analyses of human and murine terminal erythroid differentiation

An, X., Schulz, V., Li, J., Wu, K., Liu, J., Xue, F., Hu, J., Mohandas, N., & Gallagher, P. G. (2014) · Blood · doi:10.1182/blood-2014-01-548305 · Cited by 361

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Ng, S. S., Kavanagh, K. L., McDonough, M. A., Butler, D. S., Pilka, E. S., Liénard, B. M. R., Bray, J. E., Savitsky, P. A., Gileadi, O., von Delft, F., et al. (2007) · Nature · doi:10.1038/nature05971 · Cited by 329

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Gentric, G., Kieffer, Y., Mieulet, V., Goundiam, O., Bonneau, C., Némati, F., Hurbain, I., Raposo, G., Popova, T. G., Stern, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.002 · Cited by 317

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 312

CD44 regulates epigenetic plasticity by mediating iron endocytosis

Müller, S., Sindikubwabo, F., Cañeque, T., Lafon, A., Versini, A., Lombard, B., Loew, D., Wu, T., Ginestier, C., Charafe‐Jauffret, E., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-0513-5 · Cited by 309

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

Ashraf, A., Jeandriens, J., Parkes, H. G., & So, P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101494 · Cited by 306

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer’s disease hippocampus by analytical microscopy at the subcellular level

Quintana, C., Bellefqih, S., Laval, J. Y., Guerquin‐Kern, J., Wu, T., Ávila, J., Ferrer, I., Arranz, R., & Patiño, C. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.11.001 · Cited by 297

Engineered Protein Cages for Nanomaterial Synthesis

Kramer, R. M., Li, C., Carter, D. C., Stone, M. O., & Naik, R. R. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046735b · Cited by 282

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

Li, C., Zhang, Y., Cheng, X., Yuan, H., Zhu, S., Liu, J., Wen, Q., Xie, Y., Liu, J., Kroemer, G., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.012 · Cited by 266

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

Grundke, I., Fleming, J. T., Tung, Y. C., Lassmann, H., Iqbal, K., & Joshi, J. G. (1990) · Acta Neuropathologica · doi:10.1007/bf00334497 · Cited by 253

Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease

Ueda, N., & Takasawa, K. (2018) · Nutrients · doi:10.3390/nu10091173 · Cited by 251

Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

Santos, S. S., Santos, S., Pinto, A. R. T., Ramu, V. G., Heras, M., Bardajı́, E., Tavares, I., & Castanho, M. A. R. B. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00001 · Cited by 250

Screening for iron deficiency: an analysis based on bone‐marrow examinations and serum ferritin determinations in a population sample of women

Hallberg, L., Bengtsson, C., Lapidus, L., Lindstedt, G., Lundberg, P., & Hultén, L. M. (1993) · British Journal of Haematology · doi:10.1111/j.1365-2141.1993.tb03225.x · Cited by 249

Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease

Theil, E. C. (2013) · Inorganic Chemistry · doi:10.1021/ic400484n · Cited by 247

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Weïwer, M., Bittker, J. A., Lewis, T. A., Shimada, K., Yang, W. S., MacPherson, L., Dandapani, S., Palmer, M., Stockwell, B. R., Schreiber, S. L., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.09.047 · Cited by 237

Ferroportin‐mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome

De Domenico, I., Vaughn, M. B., Li, L., Bagley, D., Musci, G., Ward, D. M., & Kaplan, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601409 · Cited by 235

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

Quiles del Rey, M., & Mancias, J. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00238 · Cited by 227

Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells

Perez, M. A., Magtanong, L., Dixon, S. J., & Watts, J. L. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.019 · Cited by 226

Ferritin is secreted via 2 distinct nonclassical vesicular pathways

Truman-Rosentsvit, M., Berenbaum, D., Spektor, L., Cohen, L. A., Belizowsky-Moshe, S., Lifshitz, L., Ma, J., Li, W., Kesselman, E., Abutbul-Ionita, I., et al. (2018) · Blood · doi:10.1182/blood-2017-02-768580 · Cited by 223

Role of ferritin alterations in human breast cancer cells

Shpyleva, S., Tryndyak, V., Kovalchuk, O., Starlard‐Davenport, A., Chekhun, V. F., Beland, F. A., & Pogribny, I. P. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0849-4 · Cited by 205

Serum ferritin as an independent risk factor for severity in COVID-19 patients

Lin, Z., Long, F., Yang, Y., Chen, X., Xu, L., & Yang, M. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.06.053 · Cited by 203

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration

Muhoberac, B. B., & Vidal, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01195 · Cited by 198

Ferritin family proteins and their use in bionanotechnology

He, D., & Marles‐Wright, J. (2015) · New Biotechnology · doi:10.1016/j.nbt.2014.12.006 · Cited by 195

Ferritin in autoimmune diseases

Zandman‐Goddard, G., & Shoenfeld, Y. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.01.016 · Cited by 193

Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines

Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., Zhao, F., Zhao, Z., Wang, J., Huang, B., et al. (2021) · Oncogene · doi:10.1038/s41388-020-01622-3 · Cited by 193

The release of iron from horse spleen ferritin by reduced flavins

Sirivech, S., Frieden, E., & Osaki, S. (1974) · Biochemical Journal · doi:10.1042/bj1430311 · Cited by 187

Influence of Age on Characteristics of Polymyositis and Dermatomyositis in Adults

Marié, I., Hatron, P., Levesque, H., HACHULLA, E., Hellot, M., Michon-Pasturel, U., Courtois, H., & Devulder, B. (1999) · Medicine · doi:10.1097/00005792-199905000-00001 · Cited by 185

Visualizing biologically active small molecules in cells using click chemistry

Cañeque, T., Müller, S., & Rodriguez, R. (2018) · Nature Reviews Chemistry · doi:10.1038/s41570-018-0030-x · Cited by 185

Mitochondrial Ferritin: A New Player in Iron Metabolism

Drysdale, J., Arosio, P., Invernizzi, R., Cazzola, M., Volz, A., Corsi, B., Biasiotto, G., & Levi, S. (2002) · Blood Cells, Molecules, and Diseases · doi:10.1006/bcmd.2002.0577 · Cited by 180

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

Yang, N., Tan, S.-H., Ng, S., Shi, Y. P., Zhou, J., Tan, K. S. W., Wong, W. S. F., & Shen, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.564567 · Cited by 175

A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells

El-Hout, M., Santos, L. D., Hamaï, A., & Mehrpour, M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.07.009 · Cited by 173

Mouse brains deficient in H‐ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress

Thompson, K., Menzies, S. L., Muckenthaler, M. U., Torti, F. M., Wood, T. L., Torti, S. V., Hentze, M. W., Beard, J., & Connor, J. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10463 · Cited by 171

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration

Finazzi, D., & Arosio, P. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1329-0 · Cited by 166

Human Mitochondrial Ferritin Expressed in HeLa Cells Incorporates Iron and Affects Cellular Iron Metabolism

Corsi, B., Cozzi, A., Arosio, P., Drysdale, J., Santambrogio, P., Campanella, A., Biasiotto, G., Albertini, A., & Levi, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105372200 · Cited by 163

Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia

Campanella, A., Rovelli, E., Santambrogio, P., Cozzi, A., Taroni, F., & Levi, S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn308 · Cited by 162

Ferritins for chemistry and for life

Theil, E. C., Behera, R. K., & Tosha, T. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.05.013 · Cited by 158

Multiple Pathways for Mineral Core Formation in Mammalian Apoferritin. The Role of Hydrogen Peroxide

Zhao, G., Bou‐Abdallah, F., Arosio, P., Levi, S., Janus-Chandler, C., & Chasteen, N. D. (2003) · Biochemistry · doi:10.1021/bi027357v · Cited by 155

Iron: the cancer connection

Torti, S. V., & Torti, F. M. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100860 · Cited by 153

Metal–peptide rings form highly entangled topologically inequivalent frameworks with the same ring- and crossing-numbers

Sawada, T., Saito, A. N., Tamiya, K., Shimokawa, K., Hisada, Y., & Fujita, M. (2019) · Nature Communications · doi:10.1038/s41467-019-08879-7 · Cited by 149

A PCBP1–BolA2 chaperone complex delivers iron for cytosolic [2Fe–2S] cluster assembly

Patel, S. J., Frey, A. G., Palenchar, D. J., Achar, S. R., Zumbrennen‐Bullough, K. B., Vashisht, A. A., Wohlschlegel, J. A., & Philpott, C. C. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0330-6 · Cited by 147

Release of iron from ferritin by xanthine oxidase. Role of the superoxide radical

Bolann, B. J., & Ulvik, R. J. (1987) · Biochemical Journal · doi:10.1042/bj2430055 · Cited by 133

Regulated secretion of glycosylated human ferritin from hepatocytes

Ghosh, S., Hevi, S., & Chuck, S. L. (2003) · Blood · doi:10.1182/blood-2003-09-3050 · Cited by 132

Serum ferritin and isoferritins are tools for diagnosis of active adult Still's disease.

van Reeth, C., Moel, G. L., Lasne, Y., Revenant, M. C., AGNERAY, J., Mf, K., & Bourgeois, P. (1994) · PubMed · Cited by 130

Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells

Philpott, C. C., Ryu, M., Frey, A. G., & Patel, S. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.791962 · Cited by 128

Nuclear ferritin: A new role for ferritin in cell biology

Alkhateeb, A. A., & Connor, J. R. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.03.017 · Cited by 126

The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement

Ebrahimi, K. H., Bill, E., Hagedoorn, P., & Hagen, W. R. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1071 · Cited by 124

The purification and properties of ferritin from human serum

Worwood, M., Dawkins, S. T., Wagstaff, M., & Jacobs, A. J. (1976) · Biochemical Journal · doi:10.1042/bj1570097 · Cited by 123

Facilitated Diffusion of Iron(II) and Dioxygen Substrates into Human H-Chain Ferritin. A Fluorescence and Absorbance Study Employing the Ferroxidase Center Substitution Y34W

Bou‐Abdallah, F., Zhao, G., Biasiotto, G., Poli, M., Arosio, P., & Chasteen, N. D. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8054035 · Cited by 122

The Structure of Ferritin Cores Determined by Electron Nanodiffraction

COWLEY, J. M., Janney, D. E., Gerkin, R. C., & Buseck, P. R. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4292 · Cited by 122

Nuclear Ferritin Protects DNA From UV Damage in Corneal Epithelial Cells

Cai, C. X., Birk, D. E., & Linsenmayer, T. F. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.5.1037 · Cited by 122

Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains

Hulet, S. W., Powers, S. K., & Connor, J. R. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00077-5 · Cited by 115

Crystal Structure and Biochemical Properties of the Human Mitochondrial Ferritin and its Mutant Ser144Ala

Langlois d'Estaintot, B., Santambrogio, P., Granier, T., Gallois, B., Chevalier, J. M., Précigoux, G., Levi, S., & Arosio, P. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.04.036 · Cited by 113

Associations between acute phase reactant levels and disease activity score (DAS28) in patients with rheumatoid arthritis.

Yıldırım, K., Karatay, S., Melikoğlu, M. A., Güreser, G., Uğur, M., & Şenel, K. (2004) · PubMed · Cited by 112

Characterization of Serum Ferritin in Iron Overload: Possible Identity to Natural Apoferritin

Arosio, P., YOKOTA, M., & Drysdale, J. (1977) · British Journal of Haematology · doi:10.1111/j.1365-2141.1977.tb00640.x · Cited by 107

DMT1 Inhibitors Kill Cancer Stem Cells by Blocking Lysosomal Iron Translocation

Turcu, A. L., Versini, A., Khene, N., Gaillet, C., Cañeque, T., Müller, S., & Rodriguez, R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202000159 · Cited by 106

A mechanism of ferritin crystallization revealed by cryo-STEM tomography

Houben, L., Weissman, H., Wolf, S. G., & Rybtchinski, B. (2020) · Nature · doi:10.1038/s41586-020-2104-4 · Cited by 106

Nanoparticle ferritin-bound erastin and rapamycin: a nanodrug combining autophagy and ferroptosis for anticancer therapy

Li, Y., Wang, X., Yan, J., Liu, Y., Yang, R., Pan, D., Wang, L., Xu, Y., Li, X., & Yang, M. (2019) · Biomaterials Science · doi:10.1039/c9bm00653b · Cited by 103

Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation.

Dahan, S., Segal, G., Katz, I., Hellou, T., Tietel, M., Bryk, G., Amital, H., Shoenfeld, Y., & Dagan, A. (2020) · PubMed · Cited by 99

Serum levels of ferritin, copper, and zinc in patients with oral cancer

Mortazavi, H., Sabour, S., Baharvand, M., Manifar, S., & Akkafan, R. (2014) · Biomedical Journal · doi:10.4103/2319-4170.132888 · Cited by 96

Unique Iron Binding and Oxidation Properties of Human Mitochondrial Ferritin: A Comparative Analysis with Human H-chain Ferritin

Bou‐Abdallah, F., Santambrogio, P., Levi, S., Arosio, P., & Chasteen, N. D. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.01.007 · Cited by 96

Mutant-specific gene programs in the zebrafish

Weber, G. J., Choe, S. E., Dooley, K. A., Paffett-Lugassy, N., Zhou, Y., & Zon, L. I. (2005) · Blood · doi:10.1182/blood-2004-11-4541 · Cited by 93

Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments

He, D., Hughes, S., Vanden-Hehir, S., Georgiev, A., Altenbach, K., Tarrant, E., Mackay, C. L., Waldron, K. J., Clarke, D. J., & Marles‐Wright, J. (2016) · eLife · doi:10.7554/elife.18972 · Cited by 91

Use of Structural Phylogenetic Networks for Classification of the Ferritin-like Superfamily

Lundin, D., Poole, A. M., Sjöberg, B., & Högbom, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367458 · Cited by 90

Macrophage and epithelial cell H-ferritin expression regulates renal inflammation

Bolisetty, S., Zarjou, A., Hull, T. D., Traylor, A., Perianayagam, A., Joseph, R., Kamal, A., Arosio, P., Soares, M. P., Jeney, V., et al. (2015) · Kidney International · doi:10.1038/ki.2015.102 · Cited by 90

Photochemical Mineralization of Europium, Titanium, and Iron Oxyhydroxide Nanoparticles in the Ferritin Protein Cage

Klem, M. T., Mosolf, J., Young, M., & Douglas, T. (2008) · Inorganic Chemistry · doi:10.1021/ic701740q · Cited by 89

The Role of Iron in Friedreich’s Ataxia: Insights From Studies in Human Tissues and Cellular and Animal Models

Llorens, J. V., Soriano, S., Calap-Quintana, P., González‐Cabo, P., & Moltó, M. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00075 · Cited by 87

Moving Fe 2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates

Behera, R. K., & Theil, E. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318417111 · Cited by 86

Iron Supply via NCOA4-Mediated Ferritin Degradation Maintains Mitochondrial Functions

Fujimaki, M., Furuya, N., Saiki, S., Amo, T., Imamichi, Y., & Hattori, N. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00010-19 · Cited by 85

Serum ferritin, transferrin and soluble transferrin receptor levels in multiple sclerosis patients

Sfagos, C., Makis, A. C., Chaidos, A., Hatzimichael, E. C., Dalamaga, A., Kosma, K., & Bourantas, K. L. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1171oa · Cited by 84

Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4)

Gryzik, M., Srivastava, A., Longhi, G., Bertuzzi, M., Gianoncelli, A., Carmona, F., Poli, M., & Arosio, P. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.07.015 · Cited by 84

Isolation of point mutations that affect the folding of the H chain of human ferritin in E.coli.

Luzzago, A., & Cesareni, G. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03411.x · Cited by 83

Characterization of nuclear ferritin and mechanism of translocation

SURGULADZE, N., PATTON, S., COZZI, A., FRIED, M. G., & CONNOR, J. R. (2005) · Biochemical Journal · doi:10.1042/bj20041853 · Cited by 81

Association between serum ferritin and mortality: findings from the USA, Japan and European Dialysis Outcomes and Practice Patterns Study

Karaboyas, A., Morgenstern, H., Pisoni, R. L., Zee, J., Vanholder, R. C., Jacobson, S. H., Inaba, M., Loram, L. C., Port, F. K., & Robinson, B. M. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy190 · Cited by 80

Monodisperse Multiwall Carbon Nanotubes Obtained with Ferritin as Catalyst

Bonard, J., Chauvin, P., & Klinke, C. (2002) · Nano Letters · doi:10.1021/nl0255606 · Cited by 79

Salinomycin Derivatives Kill Breast Cancer Stem Cells by Lysosomal Iron Targeting

Versini, A., Colombeau, L., Hienzsch, A., Gaillet, C., Retailleau, P., Debieu, S., Müller, S., Cañeque, T., & Rodriguez, R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202000335 · Cited by 79

Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition

Lobello, N., Biamonte, F., Pisanu, M. E., Faniello, M. C., Jakopin, Ž., Chiarella, E., Giovannone, E. D., Mancini, R., Ciliberto, G., Cuda, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11495 · Cited by 77

Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors

Velde, G. V., Rangarajan, J. R., Toelen, J., Dresselaers, T., Ibrahimi, A., Krylychkina, O., Vreys, R., der Linden, A. V., Maes, F., Debyser, Z., et al. (2011) · Gene Therapy · doi:10.1038/gt.2011.2 · Cited by 76

Dinuclear Center of Ferritin: Studies of Iron Binding and Oxidation Show Differences in the Two Iron Sites

Treffry, A., Zhao, Z., Quail, M. A., Guest, J. R., & Harrison, P. M. (1997) · Biochemistry · doi:10.1021/bi961830l · Cited by 75

Ten years of clinical experience with adult onset Still’s disease: is the outcome improving?

Uppal, S. S., Mutairi, M. A., Hayat, S., Abraham, M., & MALAVIYA, A. N. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0440-x · Cited by 74

Ferritin Nanocages for Protein Delivery to Tumor Cells

Palombarini, F., Fabio, E. D., Boffi, A., Macone, A., & Bonamore, A. (2020) · Molecules · doi:10.3390/molecules25040825 · Cited by 74

High ferritin and low glycosylated ferritin may also be a marker of excessive macrophage activation.

Lambotte, O., Cacoub, P., Costedoat-Chalumeau, N., Moël, G. L., Amoura, Z., & Pietté, J. C. (2003) · PubMed · Cited by 73

Interactions and Reactions of Ferritin with DNA

Surguladze, N., Thompson, K., Beard, J. L., Connor, J. R., & Fried, M. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313348200 · Cited by 73

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Nai, A., Lidonnici, M. R., Federico, G., Pettinato, M., Olivari, V., Carrillo, F., Crich, S. G., Ferrari, G., Camaschella, C., Silvestri, L., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.241232 · Cited by 70

Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection

Lalueza, A., Ayuso, B., Arrieta, E., Trujillo, H., Folgueira, D., Cueto-Felgueroso, C., Serrano, A., Laureiro, J., Arévalo-Cañas, C., Castillo, C. G., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.02.018 · Cited by 70

H-Ferritin is essential for macrophages’ capacity to store or detoxify exogenously added iron

Mesquita, G., Silva, T., Gomes, A. C., Oliveira, P. F., Alves, M. G., Fernandes, R., Almeida, A. A., Moreira, A. C., & Gomes, M. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-59898-0 · Cited by 69

Development and characterization of 5-FU bearing ferritin appended solid lipid nanoparticles for tumour targeting

Jain, S., Chaurasiya, A., Gupta, Y., Jain, A., Dagur, P. K., Joshi, B., & Katoch, V. M. (2008) · Journal of Microencapsulation · doi:10.1080/02652040701799598 · Cited by 68

Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer’s Disease

Fernández, T., Martı́nez-Serrano, A., Cussó, L., Desco, M., & Ramos, M. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00260 · Cited by 66

Secretion of Ferritin by Iron-laden Macrophages and Influence of Lipoproteins

Yuan, X., Li, W., Baird, S. K., Carlsson, M., & Melefors, Ö. (2004) · Free Radical Research · doi:10.1080/10715760400011692 · Cited by 64

Iron Oxidation and Core Formation in Recombinant Heteropolymeric Human Ferritins

Mehlenbacher, M. R., Poli, M., Arosio, P., Santambrogio, P., Levi, S., Chasteen, N. D., & Bou‐Abdallah, F. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00024 · Cited by 64

Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication

Bou‐Abdallah, F., Paliakkara, J. J., Melman, G. I., & Melman, A. (2018) · Pharmaceuticals · doi:10.3390/ph11040120 · Cited by 63

Liquid Proteins—A New Frontier for Biomolecule-Based Nanoscience

Perriman, A. W., & Mann, S. (2011) · ACS Nano · doi:10.1021/nn202290g · Cited by 62

Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells

Ryu, M., Duck, K. A., & Philpott, C. C. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.09.009 · Cited by 62

H-Ferritin Affects Cisplatin-Induced Cytotoxicity in Ovarian Cancer Cells through the Modulation of ROS

Salatino, A., Aversa, I., Battaglia, A. M., Sacco, A., Vito, A. D., Santamaria, G., Chirillo, R., Veltri, P., Tradigo, G., Cello, A. D., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3461251 · Cited by 62

Image‐Based Morphological Profiling Identifies a Lysosomotropic, Iron‐Sequestering Autophagy Inhibitor

Laraia, L., Garivet, G., Foley, D. J., Kaiser, N., Müller, S., Zinken, S., Pinkert, T., Wilke, J., Corkery, D., Pahl, A., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201913712 · Cited by 61

Ferritin Assembly Revisited: A Time-Resolved Small-Angle X-ray Scattering Study

Sato, D., Ohtomo, H., Yamada, Y., Hikima, T., Kurobe, A., Fujiwara, K., & Ikeguchi, M. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b01152 · Cited by 60

Mitochondrial ferritin in neurodegenerative diseases

Yang, H., Yang, M., Guan, H., Liu, Z., Zhao, S., Takeuchi, S., Yanagisawa, D., & Tooyama, I. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.07.005 · Cited by 59

Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations

Ruscitti, P., Benedetto, P. D., Berardicurti, O., Panzera, N., Grazia, N., Lizzi, A. R., Cipriani, P., Shoenfeld, Y., & Giacomelli, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-69031-w · Cited by 59

Normal serum iron and ferritin concentrations in patients with Friedreich's ataxia

Wilson, R. B., Lynch, D. R., & Fischbeck, K. H. (1998) · Annals of Neurology · doi:10.1002/ana.410440121 · Cited by 57

Photochemical Reactivity of Ferritin for Cr(VI) Reduction

Kim, I., Hosein, H.-A., Strongin, D. R., & Douglas, T. (2002) · Chemistry of Materials · doi:10.1021/cm0207301 · Cited by 57

Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42)

Everett, J. L., Brooks, J., Lermyte, F., O’Connor, P. B., Sadler, P. J., Dobson, J., Collingwood, J. F., & Telling, N. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-67117-z · Cited by 57

Reductive release of ferritin iron: A kinetic assay

Boyer, R. F., Grabill, T. W., & Petrovich, R. M. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90513-1 · Cited by 56

Mobilization of iron from ferritin: New steps and details

La, A., Nguyen, T., Tran, K., Sauble, E., Tu, D., Gonzalez, A., Kidane, T. Z., Soriano, C., Morgan, J., Doan, M., et al. (2018) · Metallomics · doi:10.1039/c7mt00284j · Cited by 56

Expression of the genes for the ferritin H and L subunits in rat liver and heart. Evidence for tissue-specific regulations at pre- and post-translational levels

Cairo, G., Rappocciolo, E., Tacchini, L., & Schiaffonati, L. (1991) · Biochemical Journal · doi:10.1042/bj2750813 · Cited by 54

An iron hand over cancer stem cells

Hamaï, A., Cañeque, T., Müller, S., Mai, T. T., Hienzsch, A., Ginestier, C., Charafe‐Jauffret, E., Codogno, P., Mehrpour, M., & Rodriguez, R. (2017) · Autophagy · doi:10.1080/15548627.2017.1327104 · Cited by 54

Iron and ferritin in inflammation and cancer.

Torti, S. V., & Torti, F. M. (1994) · PubMed · Cited by 53

Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes

Chua, A. C. G., Knuiman, M. W., Trinder, D., Divitini, M., & Olynyk, J. K. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.129411 · Cited by 53

Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy

Kuiper, M. A., Mulder, C., van Kamp, G. J., Scheltens, P., & Wolters, E. C. (1994) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260965 · Cited by 52

Synthesis of lutetium phosphate–apoferritin core–shell nanoparticles for potential applications in radioimmunoimaging and radioimmunotherapy of cancers

Wu, H., Engelhard, M., Wang, J., Fisher, D. R., & Lin, Y. (2008) · Journal of Materials Chemistry · doi:10.1039/b717613a · Cited by 51

Tissue ferritin concentration and prognosis in carcinoma of the breast

Weinstein, R. E., Bond, B. H., Silberberg, B. K., Vaughn, C. B., Subbaiah, P., & Pieper, D. R. (1989) · Breast Cancer Research and Treatment · doi:10.1007/bf01806307 · Cited by 50

Morphology of the ferritin iron core by aberration corrected scanning transmission electron microscopy

Jian, N., Dowle, M., Horniblow, R. D., Tselepis, C., & Palmer, R. E. (2016) · Nanotechnology · doi:10.1088/0957-4484/27/46/46lt02 · Cited by 50

Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death

Buranrat, B., & Connor, J. R. (2015) · Oncology Reports · doi:10.3892/or.2015.4250 · Cited by 48

Synovial fluid ferritin in rheumatoid arthritis.

Blake, D. R., Bacon, P. A., EASTHAM, E. J., & Brigham, K. (1980) · BMJ · doi:10.1136/bmj.281.6242.715 · Cited by 47

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome

Cozzi, A., Santambrogio, P., Privitera, D., Broccoli, V., Rotundo, L. I., Garavaglia, B., Benz, R., Altamura, S., Goede, J. S., Muckenthaler, M. U., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130315 · Cited by 47

Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes

Paul, B. T., Tesfay, L., Winkler, C. R., Torti, F. M., & Torti, S. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-55907-z · Cited by 45

Apoferritin-Templated Yttrium Phosphate Nanoparticle Conjugates for Radioimmunotherapy of Cancers

Wu, H., Wang, J., Wang, Z., Fisher, D. R., & Lin, Y. (2008) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2008.177 · Cited by 44

Fe2+ substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization

Behera, R. K., Torres, R., Tosha, T., Bradley, J. M., Goulding, C. W., & Theil, E. C. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1279-x · Cited by 43

Metal binding sites of human H‐chain ferritin and iron transport mechanism to the ferroxidase sites: A molecular dynamics simulation study

Laghaei, R., Evans, D. G., & Coalson, R. D. (2013) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24251 · Cited by 43

Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo

Wilkinson, J. C., Di, X., Schönig, K., Buss, J. L., Kock, N. D., Cline, J. M., Saunders, T. L., Bujard, H., Torti, S. V., & Torti, F. M. (2006) · Biochemical Journal · doi:10.1042/bj20060063 · Cited by 41

Magnetoferritin: Process, Prospects, and Their Biomedical Applications

Xue, L., Deng, D., & Sun, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102426 · Cited by 41

A novel approach to ultrasensitive diagnosis using supramolecular protein nanoparticles

Lee, S., Lee, H., Park, J.-S., Choi, H. J., Han, K., Seo, H.-S., Ahn, K.-Y., Han, S., Cho, Y., Lee, K., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7303com · Cited by 40

Stoichiometry of iron oxidation by apoferritin

Melino, G., Stefanini, S., Chiancone, E., & Antonini, E. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80115-x · Cited by 39

Releasing iron from ferritin protein nanocage by reductive method: The role of electron transfer mediator

Koochana, P. K., Mohanty, A., Das, S., Subhadarshanee, B., Satpati, S., Dixit, A., Sabat, S. C., & Behera, R. K. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.02.011 · Cited by 39

Elevation of serum ferritin levels as a marker for active systemic lupus erythematosus.

Nishiya, K., & Hashimoto, K. (1997) · PubMed · Cited by 38

Prognostic Value of Ferritin-to-Hemoglobin Ratio in Patients with Advanced Non-Small-Cell Lung Cancer

Lee, S., Jeon, H., & Shim, B. (2019) · Journal of Cancer · doi:10.7150/jca.26853 · Cited by 38

Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells

Hayashima, K., Kimura, I., & Katoh, H. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.075 · Cited by 38

Characterization of ferritin from human placenta

Lavoie, D. J., Marcus, D. M., Otsuka, S., & Listowsky, I. (1979) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(79)90063-1 · Cited by 35

Oxidant-induced autophagy and ferritin degradation contribute to epithelial–mesenchymal transition through lysosomal iron

Sioutas, A., Vainikka, L. K., Kentson, M. U., Larsen, S. D., Wennerström, U., Jacobson, P. K., & Persson, H. L. (2017) · Journal of Inflammation Research · doi:10.2147/jir.s128292 · Cited by 35

Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells

Müller, S., Versini, A., Sindikubwabo, F., Belthier, G., Niyomchon, S., Pannequin, J., Grimaud, L., Cañeque, T., & Rodriguez, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206764 · Cited by 35

Serum Ferritin Predicted Prognosis in Patients with Locally Advanced Pancreatic Cancer

Wang, S.-L., Cao, S., Wu, R., Chi, F., Tang, M., Jin, X., & Chen, X.-D. (2015) · Future Oncology · doi:10.2217/fon.15.186 · Cited by 34

Repression of ferritin light chain translation by human eIF3

Pulos-Holmes, M. C., Srole, D. N., Lee, A. S. Y., Juarez, M. G., McSwiggen, D. T., Ingolia, N. T., & Cate, J. H. D. (2019) · eLife · doi:10.7554/elife.48193 · Cited by 34

The correlation between ferritin level and acute phase parameters in rheumatoid arthritis and systemic lupus erythematosus

Seyhan, S., Pamuk, Ö. N., Pamuk, G. E., & Çakir, N. (2014) · European Journal of Rheumatology · doi:10.5152/eurjrheumatol.2014.032 · Cited by 33

Chemical biology of salinomycin

Versini, A., Saier, L., Sindikubwabo, F., Müller, S., Cañeque, T., & Rodriguez, R. (2018) · Tetrahedron · doi:10.1016/j.tet.2018.07.028 · Cited by 33

Toxicity, biodistribution, and ex vivo MRI detection of intravenously injected cationized ferritin

Beeman, S. C., Georges, J., & Bennett, K. M. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24301 · Cited by 32

Significance of ferritin expression in formation of malignant phenotype of human breast cancer cells.

Chekhun, S. V., Lukyanova, N. Y., Shvets, Y. V., Бурлака, А. П., & Buchinska, L. G. (2014) · PubMed · Cited by 32

Iron redox pathway revealed in ferritin via electron transfer analysis

Chen, P., Meulenaere, E. D., Deheyn, D. D., & Bandaru, P. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-60640-z · Cited by 32

Serum ferritin in combination with prostate-specific antigen improves predictive accuracy for prostate cancer

Wang, X., An, P., Zeng, J., Liu, X., Wang, B., Fang, X., Wang, F., Ren, G., & Min, J. (2017) · Oncotarget · doi:10.18632/oncotarget.14977 · Cited by 31

Ferritoid, a Tissue-specific Nuclear Transport Protein for Ferritin in Corneal Epithelial Cells

Millholland, J. M., Fitch, J. M., Cai, C. X., Gibney, E. P., Beazley, K. E., & Linsenmayer, T. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210050200 · Cited by 30

Study of ferritin self-assembly and heteropolymer formation by the use of Fluorescence Resonance Energy Transfer (FRET) technology

Carmona, F., Poli, M., Bertuzzi, M., Gianoncelli, A., Gangemi, F., & Arosio, P. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.12.011 · Cited by 30

Thermodynamic and Kinetic Studies of the Interaction of Nuclear Receptor Coactivator-4 (NCOA4) with Human Ferritin

Srivastava, A. K., Flint, N., Kreckel, H. D., Gryzik, M., Poli, M., Arosio, P., & Bou‐Abdallah, F. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00246 · Cited by 30

Distribution of ferritin and hemosiderin in the liver, spleen and bone marrow of normal, phlebotomized and iron overloaded rats.

Matsuno, T., Mori, M., & Awai, M. (1985) · PubMed · doi:10.18926/amo/31521 · Cited by 28

Ferritin L and Ferritin H are differentially located within hepatic and extra hepatic organs under physiological and acute phase conditions.

Ahmad, S., Moriconi, F., Naz, N., Sultan, S., Sheikh, N., Ramadori, G. P., & Malik, I. A. (2013) · Europe PMC (PubMed Central) · Cited by 28

Early diagnostic value of low percentage of glycosylated ferritin in secondary hemophagocytic lymphohistiocytosis

Wang, Z., Wang, Y., Wang, J., Feng, C., Tian, L., & Wu, L. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0391-5 · Cited by 28

Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury

Blissett, A. R., Deng, B., Wei, P. Y., Walsh, K. J., Ollander, B., Sifford, J., Sauerbeck, A. D., McComb, D. W., McTigue, D. M., & Agarwal, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-21744-9 · Cited by 28

Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms

Ravi, V., Madhankumar, A. B., Abraham, T., Slagle‐Webb, B., & Connor, J. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221952 · Cited by 28

DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway

Feng, J., Li, C., Xu, R., Li, Y., Hou, Q., Feng, R., Wang, S., Zhang, L., & Li, C. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9762390 · Cited by 28

Elevated age-related cortical iron, ferritin and amyloid plaques in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer’s disease

Svobodová, H., Kosnáč, D., Balázsiová, Z., Tanila, H., Miettinen, P. O., Sierra, A., Vitovič, P., Wagner, A., Polák, Š., & Kopáni, M. (2019) · Physiological Research · doi:10.33549/physiolres.934383 · Cited by 28

Iron mineralization and core dissociation in mammalian homopolymeric H-ferritin: Current understanding and future perspectives

Melman, A., & Bou‐Abdallah, F. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129700 · Cited by 28

Preoperative serum ferritin is an independent prognostic factor for liver cancer after hepatectomy

Wu, S., Zhang, Z., Cheng, N., Xiong, X.-Z., & Yang, L. (2019) · Surgical Oncology · doi:10.1016/j.suronc.2019.05.013 · Cited by 25

Serum ferritin concentration in subacute thyroiditis

Sakata, S., NAGAI, K., Maekawa, H., Kimata, Y., Komaki, T., Nakamura, S., & Miura, K. (1991) · Metabolism · doi:10.1016/0026-0495(91)90084-a · Cited by 24

Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin

Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R., & Brun, N. E. L. (2015) · Angewandte Chemie · doi:10.1002/ange.201507486 · Cited by 24

Development of a bionanotechnological phosphate removal system with thermostable ferritin

Jacobs, J. F., Hasan, M., Paik, K. H., Hagen, W. R., & van Loosdrecht, M. C. M. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22612 · Cited by 24

Targeting Cancer Stem Cells with Small Molecules

Müller, S., Cañeque, T., Acevedo, V., & Rodriguez, R. (2017) · Israel Journal of Chemistry · doi:10.1002/ijch.201600109 · Cited by 23

Mutant L-chain ferritins that cause neuroferritinopathy alter ferritin functionality and iron permeability

McNally, J., Mehlenbacher, M. R., Luscieti, S., Smith, G. L., Reutovich, A. A., Poli, M., Arosio, P., & Bou‐Abdallah, F. (2019) · Metallomics · doi:10.1039/c9mt00154a · Cited by 23

Poor prognostic impact of high serum ferritin levels in patients with a lower risk of diffuse large B cell lymphoma

Kim, D. J., Kim, T., Jeong, J., Jo, J., Lee, W. S., Shin, H., Lee, J. H., & Lee, H. S. (2020) · International Journal of Hematology · doi:10.1007/s12185-019-02816-6 · Cited by 23

Iron–oxide minerals in the human tissues

Svobodová, H., Kosnáč, D., Tanila, H., Wagner, A., Trnka, M., Vitovič, P., Hlinková, J., Vavrinský, E., Ehrlich, H., Polák, Š., et al. (2020) · BioMetals · doi:10.1007/s10534-020-00232-6 · Cited by 23

Ascorbate-mediated Iron Release from Ferritin in the Presence of Alloxan

Sakurai, K., Nabeyama, A., & Fujimoto, Y. (2006) · BioMetals · doi:10.1007/s10534-005-1300-x · Cited by 22

P/CAF/p300 complex binds the promoter for the heavy subunit of ferritin and contributes to its tissue-specific expression

Bevilacqua, M. A., Faniello, M. C., Russo, T., Cimino, F., & Costanzo, F. S. (1998) · Biochemical Journal · doi:10.1042/bj3350521 · Cited by 22

Apoferritin Attenuates Experimental Allergic Encephalomyelitis in SJL Mice

LeVine, S. M., Maiti, S., Emerson, M. R., & Pedchenko, T. V. (2002) · Developmental Neuroscience · doi:10.1159/000065694 · Cited by 21

Variable Expression of Nuclear Receptor Coactivator 4 (NcoA4) During Mouse Embryonic Development

Kollara, A., & Brown, T. J. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955294 · Cited by 21

Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre

Bradley, J. M., Svistunenko, D. A., Moore, G. R., & Brun, N. E. L. (2017) · Metallomics · doi:10.1039/c7mt00187h · Cited by 19

Mass spectrometry reveals the assembly pathway of encapsulated ferritins and highlights a dynamic ferroxidase interface

Ross, J., Lambert, T., Piergentili, C., He, D., Waldron, K. J., Mackay, C. L., Marles‐Wright, J., & Clarke, D. J. (2020) · Chemical Communications · doi:10.1039/c9cc08130e · Cited by 19

Multifunctional Ferritin Nanoparticles as Theranostics for Imaging-Guided Tumor Phototherapy

Zhang, J., Zeng, Y., Su, M., Yu, M., Zhang, Y., Cheng, H., Zheng, H., Liu, J., Wang, X., Lei, Z., et al. (2019) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2019.2788 · Cited by 18

The association between serum ferritin with colorectal cancer.

Feng, Z., Chen, J., Feng, J., Shen, F., Cai, W.-S., Cao, J., & Xu, B. (2015) · PubMed Central · Cited by 17

Interaction between macrophages and ferroptosis

Yang, Y., Wang, Y., Guo, L., Gao, W., Tang, T.-L., & Yan, M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04775-z · Cited by 401

Ferritin – from iron, through inflammation and autoimmunity, to COVID-19

Mahroum, N., Alghory, A., Kiyak, Z., Alwani, A., Seida, R., Alrais, M., & Shoenfeld, Y. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102778 · Cited by 217

Serum ferritin as a predictive biomarker in COVID-19. A systematic review, meta-analysis and meta-regression analysis

Kaushal, K., Kaur, H., Sarma, P., Bhattacharyya, A., Sharma, D. J., Prajapat, M., Pathak, M., Kothari, A., Kumar, S., Rana, S. V., et al. (2021) · Journal of Critical Care · doi:10.1016/j.jcrc.2021.09.023 · Cited by 177

Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study

Jiang, Z., Wang, H., Qi, G., Jiang, C., Chen, K., & Yan, Z. (2022) · IUBMB Life · doi:10.1002/iub.2656 · Cited by 139

Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner

Wang, K., Wang, M., Liao, X., Gao, S., Hua, J., Wu, X., Guo, Q., Xu, W., Sun, J., He, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35492-y · Cited by 137

Emerging and Dynamic Biomedical Uses of Ferritin

Chiou, B., & Connor, J. R. (2018) · Pharmaceuticals · doi:10.3390/ph11040124 · Cited by 119

Ferritin

Mahomoodally, M. F., & Fatimah-Tuz-Zohra, J. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819096-8.00024-0 · Cited by 1

A novel view of ferritin in cancer

Pandya, B., & Connor, J. R. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188917 · Cited by 72

Ferritin: Master Regulator of Iron Metabolism in Health and Disease

Ibe, O. E., Okorie, N., Abunimye, D. A., Ezaka, E. A., Ibekailo, S. N., Victor, C. C., Enyi, J. O., Oguji, C. E., Njar, V. E., & Igene, A. I. (2025) · Physiology · doi:10.5772/intechopen.1012713 · Cited by 2

The many faces of the octahedral ferritin protein

Watt, R. K. (2011) · BioMetals · doi:10.1007/s10534-011-9415-8 · Cited by 98