The DOI matches its Crossref record; 215 of the 217 references it cites were found in a registry or an index.
Chemistry and biology of ferritin
Open accessAbstract
Iron is an essential element required by cells and has been described as a key player in ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming multimeric assemblies with crystalline iron cores. We discuss the latest findings on ferritin structure and activity and its link to cell metabolism and ferroptosis. The chemistry of iron, including its oxidation states, is important for its biological functions, its reactivity, and the biology of ferritin. Ferritin can be localized in different cellular compartments and secreted by cells with a variety of functions depending on its spatial context. Here, we discuss how cellular ferritin localization is tightly linked to its function in a tissue-specific manner, and how impairment of iron homeostasis is implicated in diseases, including cancer and coronavirus disease 2019. Ferritin is a potential biomarker and we discuss latest research where it has been employed for imaging purposes and drug delivery.
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“At a steady state, the serum ferritin (SF) concentration reasonably reflects the total body iron stores.”
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Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Autophagy promotes ferroptosis by degradation of ferritin
Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084
Ferroptosis is an autophagic cell death process
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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
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Interaction between macrophages and ferroptosis
Yang, Y., Wang, Y., Guo, L., Gao, W., Tang, T.-L., & Yan, M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04775-z · Cited by 401
Ferritin – from iron, through inflammation and autoimmunity, to COVID-19
Mahroum, N., Alghory, A., Kiyak, Z., Alwani, A., Seida, R., Alrais, M., & Shoenfeld, Y. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102778 · Cited by 217
Kaushal, K., Kaur, H., Sarma, P., Bhattacharyya, A., Sharma, D. J., Prajapat, M., Pathak, M., Kothari, A., Kumar, S., Rana, S. V., et al. (2021) · Journal of Critical Care · doi:10.1016/j.jcrc.2021.09.023 · Cited by 177
Jiang, Z., Wang, H., Qi, G., Jiang, C., Chen, K., & Yan, Z. (2022) · IUBMB Life · doi:10.1002/iub.2656 · Cited by 139
Wang, K., Wang, M., Liao, X., Gao, S., Hua, J., Wu, X., Guo, Q., Xu, W., Sun, J., He, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35492-y · Cited by 137
Metadata
- Authors
- Plays, M., Müller, S., & Rodriguez, R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-04-21
- Volume
- 13
- Issue
- 5
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- PMC
- PMC8083198
- OpenAlex
- W3154029091
- Cited by
- 232
- References
- 217
- Citations by year
- 2026: 42 · 2025: 63 · 2024: 48 · 2023: 41 · 2022: 32 · 2021: 6
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Metallomics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- European Research Council
- Horizon 2020 Framework Programme (647973)
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- ferritin, iron storage, ferroptosis, iron oxidation state, iron homeostasis, cancer, COVID-19 pandemic, biomarkers, imaging, drug delivery
- MeSH terms
- Ferroptosis, COVID-19, SARS-CoV-2, Biotechnology, Ceruloplasmin, Ferritins, Glycosylation, Homeostasis, Humans, Inflammation, Iron, Neoplasms, Prognosis, Tissue Distribution, Biomarkers, Drug Delivery Systems, Nanotechnology
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