The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mitochondrial DNA sequences from a 7000-year old brain
Open accessAbstract
Pieces of mitochondrial DNA from a 7000-year-old human brain were amplified by the polymerase chain reaction and sequenced. Albumin and high concentrations of polymerase were required to overcome a factor in the brain extract that inhibits amplification. For this and other sources of ancient DNA, we find an extreme inverse dependence of the amplification efficiency on the length of the sequence to be amplified. This property of ancient DNA distinguishes it from modern DNA and thus provides a new criterion of authenticity for use in research on ancient DNA. The brain is from an individual recently excavated from Little Salt Spring in southwestern Florida and the anthropologically informative sequences it yielded are the first obtained from archaeologically retrieved remains. The sequences show that this ancient individual belonged to a mitochondrial lineage that is rare in the Old World and not previously known to exist among Native Americans. Our finding brings to three the number of maternal lineages known to have been involved in the prehistoric colonization of the New World.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Mitochondrial DNA and human evolution
Cann, R. L., Stoneking, M., & Wilson, A. C. (1987) · Nature · doi:10.1038/325031a0 · Cited by 3,100
Self-citation
Cited by
Identification of the remains of the Romanov family by DNA analysis
Gill, P., Ivanov, P. L., Kimpton, C., Piercy, R., Benson, N., Tully, G., Evett, I., Hagelberg, E., & Sullivan, K. (1994) · Nature Genetics · doi:10.1038/ng0294-130 · Cited by 693
Polymerase chain reaction: basic protocol plus troubleshooting and optimization strategies
Lorenz, T. C. (2012) · Journal of Visualized Experiments · doi:10.3791/3998 · Cited by 493
Orlando, L., Allaby, R., Skoglund, P., Der Sarkissian, C., Stockhammer, P. W., Ávila-Arcos, M. C., Fu, Q., Krause, J., Willerslev, E., Stone, A. C., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-020-00011-0 · Cited by 411
mtDNA Analysis of a Prehistoric Oneota Population: Implications for the Peopling of the New World
Stone, A. C., & Stoneking, M. (1998) · The American Journal of Human Genetics · doi:10.1086/301838 · Cited by 287
Eglinton, G., & Logan, G. A. (1991) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1991.0081 · Cited by 249
Metadata
- Authors
- Pääbo, S., Gifford, J. A., & Wilson, A. C.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1988
- Volume
- 16
- Issue
- 20
- Pages
- 9775-9787
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2168536110
- Cited by
- 489
- References
- 3
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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