The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases
Open accessAbstract
Recently we tentatively identified, by sequence comparison, central domains of the NS3 proteins of flaviviruses and the respective portion of the pestivirus polyprotein as RNA helicases (A.E.G. et al., submitted). Alignment of the N-proximal domains of the same proteins revealed conservation of short sequence stretches resembling those around the catalytic Ser, His and Asp residues of chymotrypsin-like proteases. A statistically significant similarity has been detected between the sequences of these domains and those of the C-terminal serine protease domains of alphavirus capsid proteins. It is suggested that flavivirus NS3 and the respective pestivirus protein contain at least two functional domains, the N-proximal protease and the C-proximal helicase one. The protease domain is probably involved in the processing of viral non-structural proteins.
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Cites
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[47] Establishing homologies in protein sequences
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Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses
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Neurath, H. (1984) · Science · doi:10.1126/science.6369538 · Cited by 644
Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus
Collett, M. S., Larson, R., Gold, C., Strick, D., Anderson, D. K., & Purchio, A. F. (1988) · Virology · doi:10.1016/0042-6822(88)90672-1 · Cited by 478
A new superfamily of replicative proteins
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Self-citationComplete nucleotide sequence of the Japanese encephalitis virus genome RNA
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Cited by
The alphaviruses: gene expression, replication, and evolution.
Strauss, J. H., & Strauss, E. G. (1994) · Microbiological Reviews · doi:10.1128/mmbr.58.3.491-562.1994 · Cited by 2,221
Molecular biology of flaviviruses
Lindenbach, B. D., & Rice, C. M. (2003) · Advances in Virus Research · doi:10.1016/s0065-3527(03)59002-9 · Cited by 853
Weaver, S. C., & Vasilakis, N. (2009) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2009.02.003 · Cited by 531
Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily
den Boon, J. A., Snijder, E. J., Chirnside, E. D., de Vries, A. A., Horzinek, M. C., & Spaan, W. J. (1991) · Journal of Virology · doi:10.1128/jvi.65.6.2910-2920.1991 · Cited by 391
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Metadata
- Authors
- Gorbalenya, A. E., Donchenko, A. P., Koonin, E. V., & Blinov, V. M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 17
- Issue
- 10
- Pages
- 3889-3897
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2078798933
- Cited by
- 255
- References
- 27
- FWCI
- 21.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Gorbalenya, A. E., Donchenko, A. P., Koonin, E. V., & Blinov, V. M. (1989). N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases. Nucleic Acids Research. https://doi.org/10.1093/nar/17.10.3889
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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