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The transcriptionally-active MMTV promoter is depleted of histone H1
Open accessAbstract
We have used an ultraviolet light cross-linking and immunoadsorption assay to demonstrate that histones H1 and H2B are bound to the repressed MMTV promoter. Hormone activation results in reduced H1 content with little or no change in H2B. High resolution analysis of the glucocorticoid-inducible DNaseI hypersensitive region demonstrates an NF-1 footprint as well as specific sites of enhanced cleavage on nucleosome B and in the nucleosome B/nucleosome A linker. These results are consistent with a model in which binding of the glucocorticoid receptor to glucocorticoid regulatory elements on the surface of nucleosome B induces a chromatin transition that is necessary for transcription factor (NF-1 and TFIID) recruitment to the MMTV promoter. We hypothesize that association of histone H1 with important cis-elements on the promoter masks these sites, and glucocorticoid-induced displacement of H1 is necessary to expose factor binding sites at the 3' edge of nucleosome B, in the nucleosome B/nucleosome A linker and at the 5' edge of nucleosome A.
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Cites
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Cited by
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Pruss, D., Reeves, R., Bushman, F. D., & Wolffe, A. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31494-1 · Cited by 173
Factors controlling the expression of mouse mammary tumour virus
Günzburg, W. H., & Salmons, B. (1992) · Biochemical Journal · doi:10.1042/bj2830625 · Cited by 81
Two Chromatin Remodeling Activities Cooperate during Activation of Hormone Responsive Promoters
Vicent, G. P., Zaurin, R., Nacht, A. S., Li, A., Font-Mateu, J., Le Dily, F., Vermeulen, M., Mann, M., & Beato, M. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000567 · Cited by 55
Metadata
- Authors
- Bresnick, E. H., Bustin, M., Marsaud, V., Richard-Foy, H., & Hager, G. L.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1992
- Volume
- 20
- Issue
- 2
- Pages
- 273-278
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2058448711
- Cited by
- 216
- References
- 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Bresnick, E. H., Bustin, M., Marsaud, V., Richard-Foy, H., & Hager, G. L. (1992). The transcriptionally-active MMTV promoter is depleted of histone H1. Nucleic Acids Research. https://doi.org/10.1093/nar/20.2.273
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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