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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Analyzing genomes with cumulative skew diagrams

Open access
Grigoriev, A.·1998·Nucleic Acids Research

Abstract

A novel method of cumulative diagrams shows that the nucleotide composition of a microbial chromosome changes at two points separated by about a half of its length. These points coincide with sites of replication origin and terminus for all bacteria where such sites are known. The leading strand is found to contain more guanine than cytosine residues. This fact is used to predict origin and terminus locations in other bacterial and archaeal genomes. Local changes, visible as diagram distortions, may represent recent genome rearrangements, as demonstrated for two strains of Escherichia coli . Analysis of the diagrams of viral and mitochondrial genomes suggests a link between the base composition bias and the time spent by DNA in a single stranded state during replication.

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Metadata

Authors
Grigoriev, A.
Venue
Nucleic Acids Research
Published
1998-05-01
Volume
26
Issue
10
Pages
2286-2290
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2157358322
Cited by
449
References
2
FWCI
4.50
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Analyzing genomes with cumulative skew diagrams. https://app.cochat.ai/papers/10.1093/nar/26.10.2286
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Grigoriev, A. (1998). Analyzing genomes with cumulative skew diagrams. Nucleic Acids Research. https://doi.org/10.1093/nar/26.10.2286

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