The InterPro protein families and domains database: 20 years on
Open accessAbstract
The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.
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From AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models (2022) · cites this paper as [19]
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- Authors
- Blum, M., Chang, H.-Y., Chuguransky, S., Grego, T., Kandasaamy, S., Mitchell, A., Nuka, G., Paysan-Lafosse, T., Qureshi, M., Raj, S., Richardson, L., Salazar, G. A., Williams, L., Bork, P., Bridge, A., Gough, J., Haft, D. H., Letunic, I., Marchler-Bauer, A., Mi, H., Natale, D. A., Necci, M., Orengo, C. A., Pandurangan, A. P., Rivoire, C., Sigrist, C. J. A., Sillitoe, I., Thanki, N., Thomas, P. D., Tosatto, S. C. E., Wu, C. H., Bateman, A., & Finn, R. D.
- Affiliations
- European Bioinformatics Institute (GB)
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
- European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany
- SIB Swiss Institute of Bioinformatics (CH)
- MRC Laboratory of Molecular Biology (GB)
- National Institutes of Health (US)
- Biobyte Solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany
- National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda MD 20894 USA
- University of Southern California (US)
- Georgetown University Medical Center (US)
- University of Padua (IT)
- University College London (GB)
- Corresponding author
- Bateman, Alex
- ORCID
- Blum, Matthias
- Chang, Hsin-Yu
- Chuguransky, Sara
- Grego, Tiago
- Kandasaamy, Swaathi
- Mitchell, Alex
- Qureshi, Matloob
- Raj, Shriya
- Richardson, Lorna
- Salazar, Gustavo A
- Williams, Lowri
- Bridge, Alan
- Gough, Julian
- Haft, Daniel H
- Letunic, Ivica
- Mi, Huaiyu
- Natale, Darren A
- Necci, Marco
- Orengo, Christine A
- Pandurangan, Arun P
- Rivoire, Catherine
- Sigrist, Christian J A
- Sillitoe, Ian
- Thanki, Narmada
- Thomas, Paul D
- Tosatto, Silvio C E
- Wu, Cathy H
- Bateman, Alex
- Finn, Robert D
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-06
- Volume
- 49
- Issue
- D1
- Pages
- D344-D354
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC7778928
- OpenAlex
- W3094967361
- Cited by
- 2,231
- References
- 28
- Citations by year
- 2026: 215 · 2025: 308 · 2024: 381 · 2023: 563 · 2022: 536 · 2021: 224 · 2020: 2
- FWCI
- 109.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- Wellcome (108433/Z/15/Z)
- Biotechnology and Biological Sciences Research Council (BB/T010541/1, BB/S020381/1, BB/N00521X/1, BB/N019172/1)
- National Science Foundation
- Division of Biological Infrastructure (1458808)
- ELIXIR
- Open Targets
- European Molecular Biology Laboratory
- National Institutes of Health
- DHHS
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- InterPro, InterProScan, protein families, protein domains, conserved sites, protein sequence annotation, proteomic signatures, Gene Ontology, REST API
- MeSH terms
- Protein Domains, COVID-19, SARS-CoV-2, Amino Acid Sequence, Proteins, Sequence Alignment, Internet, Databases, Protein, Molecular Sequence Annotation, Protein Interaction Maps
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