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Large Serine Integrase Off-Target Discovery with Deep Learning for Genome Wide PredictionPreprint

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Advances in Strategies for In Vivo Directed Evolution of Targeted Functional Genes

Wu, H., Li, Y., Chen, J., Wang, X., & Chen, K. (2025) · Catalysts · doi:10.3390/catal15121127 · Cited by 2 · see citing works

Gene-sized DNA insertion at genomic safe harbors in human cells using a site-directed transposase

(2025) · doi:10.1093/nar/gkaf1316 · Cited by 2 · see citing works

Fourth-generation gene editors: Integration-based genome engineering

Kincaid, A. E., Hewitt, A. W., & Rajendra, K. C. (2026) · Molecular Therapy Advances · doi:10.1016/j.omta.2026.201753 · Cited by 2 · see citing works

Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells

Yan, L., Zhou, L., Gao, Q., Li, L., Guo, L., Ran, Y., Zhang, L., Zhang, K., Wang, Z., Li, Y., et al. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03294-y · Cited by 1 · see citing works

Site-specific recombinases and their essential role in synthetic biology

Ba, F., & Sun, Q. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.109005 · Cited by 2 · see citing works

Programmable RNA-Guided DNA Recombination: Mechanisms, Engineering, and Applications

Agha, A. S. A. A., Hattab, D., Bakhtiar, A., Khatib, A. O. A., Abushahla, H. S., Alketbi, S., & Akour, A. A. (2026) · Biomedicines · doi:10.3390/biomedicines14092008 · Cited by 2 · see citing works

A Targeted Integration-Based CHO Cell Platform for Simultaneous Antibody Display and Secretion

Ng, J. P. Z., Mariati, M., Bi, J., Chang, M. W., & Yang, Y. (2025) · Antibodies · doi:10.3390/antib14020038 · Cited by 1 · see citing works

Highly enhanced transgene integration in human pluripotent stem cells by serine integrase BxbIPreprint

Autio, M. I., & Perrin, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.18.619063 · Cited by 1 · see citing works

Library transgenesis in zebrafish through delayed site-specific mosaic integration for in vivo pooled screening of transgenesPreprint

Bracha, S., Amsterdam, A., Xu, Y., Chitayat, L., Sinha, A., & Boyden, E. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.30.702415 · Cited by 1 · see citing works

Growth characteristics of children with 21-hydroxylase deficiency and the value of steroid hormones in height assessment

Chong, H., Pi, Y., Zhang, Y., Li, Y., Xing, Y., & Zhang, H. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05643-3

Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3

Gwon, L. W., Seong, J. B., Yeo, H.-G., Oh, Y., Park, J., Won, J., Park, S. J., Kim, Y., Huh, J., Kim, A., et al. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.102988

An autonomous system for multi-objective continuous evolution at scalePreprint

Boileau, R. M., Golas, S. M., Ma, Q., Jiang, B., Aradhana, Jia, M. S., Ilieva, N., Baydush, A., Fu, H., & Chory, E. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.02.709196

From Gene Knockouts to Genome Remodeling: Large DNA Fragment Deletion Technologies in Plants

Hou, J., Li, H., Zhang, F., Yang, D., Xiong, Y., Zhu, X., & Wen, M. (2026) · Plants · doi:10.3390/plants15060909

PE-STAR: prime editing with SOS-triggered and RecJ-augmented repair enables high-efficiency editing in Escherichia coli

Duan, X., Zhang, H., Lv, J., Fan, X., Liu, X., Wang, Q., Zhang, F., Zhang, Q., Liu, L., Liang, L., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag285

Programmable enzymes for targeted gene insertion

Lampe, G. D., King, R. T., & Sternberg, S. H. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-01002-9

Large serine recombinase-mediated gene insertion for high-throughput screens: advantages, design principles, and applications

Martella, A., Matreyek, K. A., & Fisher, D. I. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag907

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrasesPreprint

Ioannidi, E. I., Yarnall, M. T. N., Schmitt-Ulms, C., Krajeski, R. N., Lim, J., Villiger, L., Zhou, W., Jiang, K., Roberts, N., Zhang, L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.01.466786 · Cited by 35 · see citing works

Directed evolution of a recombinase for improved genomic integration at a native human sequence

Sclimenti, C. R. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.24.5044 · Cited by 112 · see citing works

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells

Fauser, F., Arangundy‐Franklin, S., Davis, J. E., Liu, L., Schmidt, N., Rodriguez, L., Xia, D. F., Nguyen, N., Zhou, Y., Scarlott, N. A., et al. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03186-1 · Cited by 17 · see citing works

Establishment of an improved high-efficiency thermal asymmetric interlaced PCR for identification of genomic integration sites mediated by phiC31 integrase

Qu, Z. Z. M., & Ren, F. (2012)

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Pandey, S., Gao, X. D., Krasnow, N. A., McElroy, A. N., Tao, Y., Duby, J. E., Steinbeck, B. J., McCreary, J., Pierce, S. E., Tolar, J., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01227-1 · Cited by 207 · see citing works