The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
KEGG: biological systems database as a model of the real world
Open accessAbstract
KEGG (https://www.kegg.jp/) is a database resource for representation and analysis of biological systems. Pathway maps are the primary dataset in KEGG representing systemic functions of the cell and the organism in terms of molecular interaction and reaction networks. The KEGG Orthology (KO) system is a mechanism for linking genes and proteins to pathway maps and other molecular networks. Each KO is a generic gene identifier and each pathway map is created as a network of KO nodes. This architecture enables KEGG pathway mapping to uncover systemic features from KO assigned genomes and metagenomes. Additional roles of KOs include characterization of conserved genes and conserved units of genes in organism groups, which can be done by taxonomy mapping. A new tool has been developed for identifying conserved gene orders in chromosomes, in which gene orders are treated as sequences of KOs. Furthermore, a new dataset called VOG (virus ortholog group) is computationally generated from virus proteins and expanded to proteins of cellular organisms, allowing gene orders to be compared as VOG sequences as well. Together with these datasets and analysis tools, new types of pathway maps are being developed to present a global view of biological processes involving multiple organism groups.
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Citations
Cites
KEGG for taxonomy-based analysis of pathways and genomes
Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M., & Ishiguro-Watanabe, M. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac963 · Cited by 5,833
Self-citationToward understanding the origin and evolution of cellular organisms
Kanehisa, M. (2019) · Protein Science · doi:10.1002/pro.3715 · Cited by 5,509
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Mageau, E., Derbowka, R., Dickinson, N., Lefort, N., Kovala, A. T., Boreham, D. R., Tai, T. C., Thome, C., & Tharmalingam, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47080589 · Cited by 12
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Kumar, S., Aceves, M., Granados, J., Guerra, L., Juarez, F., Novilla, E., C. Leandro, A., Leandro, M., Peralta, J., Williams-Blangero, S., et al. (2025) · Biomolecules · doi:10.3390/biom15030381 · Cited by 6
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Uncovering the metabolic impact of acute psychological stress in young adults
Frempong, G. A., Goni, G., Lorenzo-Tejedor, M., De la Cámara, C., Lázaro, J., Mangialavori Rasia, E., Aguiló, J., Bailon, R., & Bernal, M. L. (2026) · Scientific Reports · doi:10.1038/s41598-025-29572-4 · Cited by 3
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Ferrer-González, F. X., Heal, K. R., Sacks, J. S., Romero-Maysonet, Y., Finch, A. H., Carlson, L. T., Coe, L. S. Y., Bartolek, Z., Luthy, C. B., Gaffney, M. P., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02313-7 · Cited by 3
Wu, W., Liao, Y., Liang, J., Huang, M., Zhang, G., Hu, Y., Yuan, C., & Li, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-09002-1 · Cited by 2
Fariha, F. T. J., Fuad, M., Saha, C. S., Hossen, S., & Hossain, M. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-13315-6 · Cited by 1
Arnoux, J. (2026) · Thèse de doctorat, Université Paris-Saclay / PPanGGOLiN · doi:10.70675/eee354d9zf63dz48ebz9444zd1809f8fb74d
Metadata
- Authors
- Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y., & Ishiguro-Watanabe, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-10-17
- Volume
- 53
- Issue
- D1
- Pages
- D672-D677
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W4403479110
- Cited by
- 2,543
- References
- 2
- FWCI
- 295.46
- Type
- journal article
- Language
- en
- Open access
- gold
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