Cited by 290Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid ChemistryDNA Repair Mechanisms

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

Open access

Opresko, P. L.·2005·Nucleic Acids Research

Open this paper in CoChat — free account Open PDF

Abstract

The ends of linear chromosomes are capped by protein-DNA complexes termed telomeres. Telomere repeat binding factors 1 and 2 (TRF1 and TRF2) bind specifically to duplex telomeric DNA and are critical components of functional telomeres. Consequences of telomere dysfunction include genomic instability, cellular apoptosis or senescence and organismal aging. Mild oxidative stress induces increased erosion and loss of telomeric DNA in human fibroblasts. We performed binding assays to determine whether oxidative DNA damage in telomeric DNA alters the binding activity of TRF1 and TRF2 proteins. Here, we report that a single 8-oxo-guanine lesion in a defined telomeric substrate reduced the percentage of bound TRF1 and TRF2 proteins by at least 50%, compared with undamaged telomeric DNA. More dramatic effects on TRF1 and TRF2 binding were observed with multiple 8-oxo-guanine lesions in the tandem telomeric repeats. Binding was likewise disrupted when certain intermediates of base excision repair were present within the telomeric tract, namely abasic sites or single nucleotide gaps. These studies indicate that oxidative DNA damage may exert deleterious effects on telomeres by disrupting the association of telomere-maintenance proteins TRF1 and TRF2.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/nar/gki273

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709
Protection of mammalian telomeres
de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942
Control of Human Telomere Length by TRF1 and TRF2
Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768
Identification of Human Rap1
Li, B., Oestreich, S. C., & de Lange, T. (2000) · Cell · doi:10.1016/s0092-8674(00)80858-2 · Cited by 609
T‐loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang
Stansel, R. M., de Lange, T., & Griffith, J. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5532 · Cited by 562
Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
Sutherland, B. M., Bennett, P. V., Sidorkina, O. M., & Laval, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.103 · Cited by 473

Flagged first, then by citations

Show all 40 references

Sorted by citations

Items 201–290 of 290

G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells
Piekna‐Przybylska, D., Bambara, R. A., Maggirwar, S. B., & Dewhurst, S. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1796268 · Cited by 9
Theoretical analysis of the effects of guanine oxidative damage on the properties of B-DNA telomere fragments
Cysewski, P., & Czeleń, P. (2007) · Journal of Molecular Modeling · doi:10.1007/s00894-007-0186-7 · Cited by 9
Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome
Pańczyszyn, A., Boniewska‐Bernacka, E., Wertel, I., Sadakierska−Chudy, A., & Goc, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168652 · Cited by 9
Back to the future: The intimate and evolving connection between telomere-related factors and genotoxic stress
Barcenilla, B. B., & Shippen, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.aw119.008145 · Cited by 8
Accelerated telomere shortening in β-thalassemia/HbE patients
Chaichompoo, P., Pattanapanyasat, K., Winichagoon, P., Fucharoen, S., & Svasti, S. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.01.003 · Cited by 8
Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex
Cao, C., Gong, W., Shuai, Y., Rasouli, S., Ge, Q., Anam Qadir, K. H. A. N., Dakic, A., Putluri, N., Shvets, G. B., Zheng, Y., et al. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01367-0 · Cited by 8
Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer
Sung, J. (2025) · Cells · doi:10.3390/cells14201613 · Cited by 8
Comparison between two FISH techniques in the in vitro study of cytogenetic markers for low-dose X-ray exposure in human primary fibroblasts
Nieri, D., Berardinelli, F., Antoccia, A., Tanzarella, C., & Sgura, A. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00141 · Cited by 7
Telomeres, Aging, and Nutrition
Dhillon, V. S., Bull, C. F., & Fenech, M. F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00010-8 · Cited by 8
The crosstalk between telomeres and DNA repair mechanisms: an overview to mammalian somatic cells, germ cells, and preimplantation embryos
Tire, B., Talibova, G., & Öztürk, S. (2024) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-03008-2 · Cited by 8
Replicative senescence induction in single cells is not predicted by telomere length, dysfunction, or oxidation
Passanisi, V. J., & Spencer, S. L. (2026) · iScience · doi:10.1016/j.isci.2026.114801 · Cited by 6
Male Germ Cell Telomeres and Chemical Pollutants
Baccari, G. C., Iurato, G., Santillo, A., & Dale, B. (2023) · Biomolecules · doi:10.3390/biom13050745 · Cited by 6
Associations between exposure to ambient air pollution and changes in blood telomeres in young people: A repeated-measure study
Zhu, X., Li, Z., Wang, Z., Chen, G., Qian, Y. N., Wang, Z., Li, X., & Wei, Y. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139053 · Cited by 6
ROS and Oxidative Stress in Cancer: Recent Advances
Varol, M. (2020) · Springer eBooks · doi:10.1007/978-981-15-7586-0_6 · Cited by 6
A Dual Face of APE1 in the Maintenance of Genetic Stability in Monocytes: An Overview of the Current Status and Future Perspectives
Betlej, G., Bator, E., Pyrkosz, A., & Kwiatkowska, A. (2020) · Genes · doi:10.3390/genes11060643 · Cited by 6
Structural and energetic heterogeneities of canonical and oxidized central guanine triad of B-DNA telomeric fragments
Cysewski, P., & Czeleń, P. (2009) · Journal of Molecular Modeling · doi:10.1007/s00894-008-0438-1 · Cited by 6
Oxidative DNA Damage and Telomere Shortening
Richter, T., & von Zglinicki, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-72974-9_8 · Cited by 6
α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway
Καπετάνου, Μ., Athanasopoulou, S., Goutas, A., Makatsori, D., Trachana, V., & Gonos, E. S. (2024) · Antioxidants · doi:10.3390/antiox13101258 · Cited by 5
The impact of exercise on telomere length dynamics: Molecular mechanisms and implications in athletes (Review)
Baliou, S., Spanakis, M., Apetroaei, M.-M., Ιωάννου, Π., Fragkiadaki, P., Fragkiadoulaki, I., Renieri, E. A., Vakonaki, E., Tzatzarakis, M. N., Nosyrev, A. E., et al. (2025) · World Academy of Sciences Journal · doi:10.3892/wasj.2025.344 · Cited by 6
Structural and energetic consequences of oxidation of d(ApGpGpGpTpT) telomere repeat unit in complex with TRF1 protein
Cysewski, P., & Czeleń, P. (2010) · Journal of Molecular Modeling · doi:10.1007/s00894-010-0730-8 · Cited by 4
Effect of Quadruplex Conformation on Radiation-Induced Formation of 8-Hydroxyguanine and Unaltered Base Release in Polyguanylic Acid
Grygoryev, D., & Zimbrick, J. D. (2009) · Radiation Research · doi:10.1667/rr1806.1 · Cited by 5
Mitigation of Damage from Reactive Oxygen Species and Ionizing Radiation by Ketone Body Esters
Curtis, W., Kemper, M., Miller, A. C., Pawlosky, R. J., King, M. T., & Veech, R. L. (2016) · Oxford University Press eBooks · doi:10.1093/med/9780190497996.003.0027 · Cited by 5
Environment and sex control lifespan and telomere length in wild-derived African killifishPreprint
Reichard, M., Giannetti, K., Ferreira, T., Vrtílek, M., Polačik, M., Blažek, R., & Ferreira, M. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.03.280792 · Cited by 5
Inhalation of concentrated ambient PM2.5 promotes inactivation of telomerase reverse transcriptase, telomere shortening, and senescence of multiple cell types in mice
Gomes, D., Zhao, J., Malovichko, M. V., Haberzettl, P., Conklin, D. J., & O’Toole, T. E. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf045 · Cited by 5
A Perceived Dissociation Between Systemic Chronic Inflammation, Age, and the Telomere/Telomerase System in Type 2 Diabetes
Sater, M. S., AlDehaini, D. M. B., Malalla, Z. H. A., Ali, M. E., & Giha, H. A. (2025) · Biomedicines · doi:10.3390/biomedicines13030531 · Cited by 4
The Telomere Length Signature in Leukemias—From Molecular Mechanisms Underlying Telomere Shortening to Immunotherapeutic Options Against Telomerase
Baliou, S., Pelagiadis, I., Apetroaei, M.-M., Vakonaki, E., Arsene, A. L., Hatzidaki, E., Tzatzarakis, M. N., Ιωάννου, Π., Tsatsakis, A. M., & Stiakaki, E. (2025) · Cancers · doi:10.3390/cancers17121936 · Cited by 6
Telomere uncapping by common oxidative guanine lesions: Insights from atomistic models
Wieczór, M., & Czub, J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.006 · Cited by 4
The Role of Telomeres in Senescence, Aging and Disease: Fiction and Reality
Saretzki, G. C. (2025) · OBM Geriatrics · doi:10.21926/obm.geriatr.2503324 · Cited by 3
ROS: their roles in diminished ovarian reserve
Chen, X., & 刘丹卓 (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1823452 · Cited by 3
Mammalian MutY Homolog (MYH or MUTYH) is Critical for Telomere Integrity under Oxidative Stress
Gupta, A., Hwang, B., Benyamien-Roufaeil, D. S., Jain, S., Liu, S., Gonzales, R., Brown, R. A., Zalzman, M., & Lu, A.-L. (2022) · OBM Geriatrics · doi:10.21926/obm.geriatr.2202196 · Cited by 3
Effects of nanomaterial exposure on telomere dysfunction, hallmarks of mammalian and zebrafish cell senescence, and zebrafish mortality
Yin, F., Zhou, Y. M., Xie, D., Hu, J., & Luo, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102062 · Cited by 3
The Functioning of “Aged” Heterochromatin
Teimuraz, A., Tinatin, A., & Jamlet, R. (2012) · InTech eBooks · doi:10.5772/35651 · Cited by 3
The Role of WRN Helicase/Exonuclease in DNA Replication
Lynne, S., & Penelope, A. (2013) · InTech eBooks · doi:10.5772/51520 · Cited by 3
Number and function impairment of resident C-Kit+ cardiac stem cells in mice with renal dysfunction caused by 5/6 nephrectomy
Qiu, J., Sun, L., Li, S., Yáng, X., Lu, Y., & Li, Y. (2013) · Renal Failure · doi:10.3109/0886022x.2013.815108 · Cited by 3
Oxidative Stress in Orchestrating Genomic Instability-Associated Cancer Progression
Bhakta-Guha, D., & Guha, G. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_50 · Cited by 2
Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis
Min, J., Castillo-González, C., Barcenilla, B. B., Yeo, I.-C., Xie, X., Bose, S., Ortiz‐Morea, F. A., Liu, D., Canal, E., Curtis, D., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70441-z · Cited by 2
Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery
Taglialatela, A., & Ciccia, A. (2026) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-030222-114544 · Cited by 3
Cellular senescence during aging and chronic liver diseases
Jurk, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00005-5 · Cited by 2
Mediterranean diet and telomere length: aspects from obesity
Arslan, N., & Köksal, E. (2024) · Nutrition & Food Science · doi:10.1108/nfs-07-2023-0140 · Cited by 2
Structural and energetic properties of canonical and oxidized telomeric complexes studied by molecular dynamics simulations
Czeleń, P., & Cysewski, P. (2013) · Journal of Molecular Modeling · doi:10.1007/s00894-013-1859-z · Cited by 2
Tolerance of N 2 -heteroaryl modifications on guanine bases in a DNA G-quadruplex
MASAKI, Y., Inde, T., Maruyama, A., & Seio, K. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob03100b · Cited by 2
A Multilevel Approach to the Causes of Genetic Instability in Stem Cells
González, E. A. P. (2022) · Springer eBooks · doi:10.1007/978-981-16-6016-0_26-1 · Cited by 2
A Multilevel Approach to the Causes of Genetic Instability in Stem Cells
González, E. A. P. (2022) · Springer eBooks · doi:10.1007/978-981-19-2655-6_26 · Cited by 3
Enhanced induction of abnormal telomere FISH signals in response to oxidative DNA damage
Sakamoto, Y., Shiraishi, K., & Kodama, S. (2024) · Journal of Radiation Research · doi:10.1093/jrr/rrad102 · Cited by 2
The emerging influences of telomere and telomerase in inflammatory bowel disease and cancer progression
Gan, W., Pei, X., Yang, G., Zheng, G., Pan, Y., & Hu, P. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101174 · Cited by 1
Dna Glycosylases Remove Oxidized Base Damages From G-Quadruplex Dna Structures
Zhou, J. (2015) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 1
Cell Cycle, DNA Damage Repair Systems, and Impact of Redox Regulation in Cancer
Bansal, M. P. (2023) · Springer eBooks · doi:10.1007/978-981-99-7342-2_8 · Cited by 1
Telomeres Shortening: A Mere Replicometer?
Victorelli, S. G., & Passos, J. F. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_7 · Cited by 1
The Modulatory Effect of Physical Activity on APE1-Mediated Telomere Length and Stability; A Narrative Review
Betlej, G., Kwiatkowska, A., & Bator, E. (2019) · Central European Journal of Sport Sciences and Medicine · doi:10.18276/cej.2019.4-09 · Cited by 1
Vitiligo as a potential degenerative disease: from oxidative stress to cellular senescence
Wang, Y., Chi, J., Wang, T., Zhang, Y., Li, Z., Chen, J., Liu, H., & Li, Q. (2022) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2022.06.083 · Cited by 1
Nucleotides and nucleic acids; oligo- and polynucleotides
Loakes, D. (2007) · Royal Society of Chemistry eBooks · doi:10.1039/b603852m · Cited by 1
Telomere regulation
Luke, B. (2018) · Differentiation · doi:10.1016/j.diff.2018.06.002 · Cited by 1
Estudo dos telômeros em tecido hipocampal de camundongos submetidos a um estresse psicossocial prolongado
Pereira, J. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2008.tde-25062009-085635
Studies on early cellular responses during Epstein-Barr virus infection
Chen, X. (2015) · Figshare
Estudo dos telômeros em tecido hipocampal de camundongos submetidos a um estresse psicossocial prolongado
Paulo, S. (2008)
Telomere dynamics and chemotherapy in aging and cancer
Unryn, B. M. (2005) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/13381
Effect of oxidative stress on human telomeric DNA structural dynamics and accessibility
Kim, G. (2015) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
The role of melanocyte senescence in skin ageing
Victorelli, S. G. (2018)
Mitochondria: Potential Targets for Interventions to Counteract Senescence
Lagnado, A. B., Victorelli, S. G., & Passos, J. F. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_11
The effect of Telomere Lengthening on Genetic Diseases
Bojkovic, M., & Chandra, S. (2021) · Journal of Contemporary Medicine · doi:10.16899/jcm.756562
What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence
Jia, H. (2021) · E3S Web of Conferences · doi:10.1051/e3sconf/202124503051
Oxidative Stress in Orchestrating Genomic Instability-Associated Cancer Progression
Bhakta-Guha, D., & Guha, G. (2021) · Springer eBooks · doi:10.1007/978-981-15-4501-6_50-1
Oxidative Stress and Leaf Senescence
Zentgraf, U. (2017) · Annual Plant Reviews online · doi:10.1002/9781119312994.apr0265
EPAS1 protects fibroblasts from replicative senescence through telomeric stabilityPreprint
Zhao, B., Li, K., Liu, G., Liu, X., Chang, Q., Tu, Q., Chen, Q., Huang, X., Hua, R., Xu, D., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1488721/v1
Telomere Targeting
Boccardi, V., Paolisso, G., & Mecocci, P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62143-8
Faculty Opinions recommendation of Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.
Shay, J. W. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735786589.793562218
Aging
Gunes, S. O., & Hekim, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812501-4.00016-x
Fatty acids and telomeres in humans
Fenech, M. F., Deo, P., & Dhillon, V. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823914-8.00022-7
Telomeres and cell homeostasis in aging
Victorelli, S. G., & Passos, J. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00029-x
Telomere shortening and cellular senescence induced by oxalate and nephrolithiasis urine in HK-2 cells
Chuenwisad, K. (2020) · doi:10.58837/chula.the.2020.306
Integrated analysis of hepatocellular carcinoma reveals disparate subtype of prognosis significancePreprint
Jiang, F., Jiang, X., Zhang, Z.-Y., Wang, J., & Liu, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4210755/v1
Association of Leukocyte Telomere Length and the Risk of Disease Severity and Metabolic Comorbidities in Arab Patients with Psoriasis
Alwehaidah, M. S., & Bakhiet, M. (2024) · Cytogenetic and Genome Research · doi:10.1159/000542323
Vascular Endothelial Cells and Atherosclerosis
Watanabe, T., & Fan, J. (2025) · Springer eBooks · doi:10.1007/978-981-96-3675-4_11
Telomere 3’-overhang attrition and persistent telomeric DNA damage response in failing human heartsPreprint
Ye, B., Shang, L., Yuan, X., Xu, Y., Wen, Y., Shi, Y., Xu, H., Wang, X., Margulies, K. B., Wang, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.12.669993
The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis
de Souza, R. A., Barneda, D., Karimlou, D., Bovee, N. G. P., Zheng, Y., Kahlman, E. J. E. M., Novo, C. L., Ellis, J. K., Leeke, B. J., Li, S., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116654 · Cited by 1
REPAIR OF BIPYRIMIDINE PHOTOPRODUCTS AT TELOMERES OF ULTRAVIOLET LIGHT IRRADIATED MAMMALIAN CELLS
Parikh, D. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
High Glucose and Human Endothelial Cell Ageing
Bowers, L.-L. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Influence of Individual Radiosensitivity on Biological Responses to Ionizing Radiation Dose Estimation and the Role of Telomere Maintenance
Shim, G. (2015) · theses.fr (ABES) · doi:10.70675/4612ed1dz6b2ez4556z8fbfz3f50c986c78f
Effect of nasopharyngeal carcinoma derived exosomes on the induction of tolerogenic dendritic cells
Renaud, S. (2018) · theses.fr (ABES) · doi:10.70675/41db8e5ez4572z4453zb3efz2631b3820222
Maintenance télomérique : intérêt dans le diagnostic des gliomes en lien avec le métabolisme mitochondrial
Billard, P. (2021) · theses.fr (ABES) · doi:10.70675/7d145f6az2700z4c8bzad56z3286d493fb31
Relations between aortic valve calcification and telomere lenght dynamics
Saraieva, I. (2020) · theses.fr (ABES) · doi:10.70675/c98af202z0365z444bz8ee1z337555d97246
Elucidating the molecular mechanisms of genome evolution in the budding yeast Saccharomyces cerevisiae
D’Angiolo, M. (2021) · theses.fr (ABES) · doi:10.70675/b4a54c23z9d95z4c65zac44z6e1809fed4fe
Rôle du calcium et de son homéostasie dans la sénescence cellulaire et ses effets paracrines : implication de la protéine tamponnant le calcium, CALB1
Raynard, C. (2021) · theses.fr (ABES) · doi:10.70675/65b3ef4bze3eez4ca1z8b49zf9a7c9d2a979
Rôles de très longs ARNs non codants intergéniques dans la réorganisation 3D du génome au cours de la sénescence
Ouvrard, J. (2023) · theses.fr (ABES) · doi:10.70675/f1618134z102ez441cz9ff8zade45dc23aa9
Alterations of telomere-associated genes and underlying mechanisms in hypoxic-ischemic encephalopathy
Chen, H., Lu, Y., Xiong, D., Zheng, W., & Xie, Y. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111186
The Role of Telomerase in Cellular Stress Response—Therapeutic Potential of Telomerase Inhibitors
Pawlak, S., Kostrzewa, M., Lisiak, N., & Rubiś, B. (2026) · Biomedicines · doi:10.3390/biomedicines14102171
Redox regulation of telomerase and telomeres in cancer: a critical appraisal of exposure, causality and molecular directness
Tatar, M., Khorrami, M., Kazemi, F., Masoumi, M., Babaei, S., & Khorrami, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12826-3
Chromatin signaling in aging and cellular senescence
Gagné, L. M., Couteau, F., & Mallette, F. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-19001-8.00018-0
Investigation of telomere maintenance in BRCA2 defective mammalian cell lines
Chianea, Y. G. (2014) · Brunel University Research Archive (BURA) (Brunel University London)
Psychosocial Factors and Telomere Length in Peripheral Blood
Parks, C. G., & DeRoo, L. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4776-4_7

Authors: Opresko, P. L.
Affiliations: National Institutes of Health (US)
Corresponding author: Opresko, P. L.
ORCID: Opresko, P. L.
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 2005-02-23
Volume: 33
Issue: 4
Pages: 1230-1239
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/gki273
PMC: PMC549571
OpenAlex: W2098312065
Cited by: 289
References: 40
Citations by year: 2026: 10 · 2025: 15 · 2024: 10 · 2023: 17 · 2022: 19 · 2021: 20 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 20 · 2015: 20 · 2014: 17 · 2013: 14 · 2012: 6
FWCI: 4.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: other-oa
Locations: Nucleic Acids Research (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: telomeres, TRF1, TRF2, oxidative DNA damage, 8-oxoguanine, telomeric DNA binding, base excision repair, abasic sites, telomere dysfunction, telomere shortening
MeSH terms: DNA, DNA Damage, Guanine, Humans, Telomere, Oxidative Stress, Telomeric Repeat Binding Protein 1, Telomeric Repeat Binding Protein 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks