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The tRNAscan-SE, snoscan and snoGPS web servers for the detection of tRNAs and snoRNAs

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Schattner, P., Brooks, A. N., Lowe, T. M.·2005·Nucleic Acids Research

Abstract

Transfer RNAs (tRNAs) and small nucleolar RNAs (snoRNAs) are two of the largest classes of non-protein-coding RNAs. Conventional gene finders that detect protein-coding genes do not find tRNA and snoRNA genes because they lack the codon structure and statistical signatures of protein-coding genes. Previously, we developed tRNAscan-SE, snoscan and snoGPS for the detection of tRNAs, methylation-guide snoRNAs and pseudouridylation-guide snoRNAs, respectively. tRNAscan-SE is routinely applied to completed genomes, resulting in the identification of thousands of tRNA genes. Snoscan has successfully detected methylation-guide snoRNAs in a variety of eukaryotes and archaea, and snoGPS has identified novel pseudouridylation-guide snoRNAs in yeast and mammals. Although these programs have been quite successful at RNA gene detection, their use has been limited by the need to install and configure the software packages on UNIX workstations. Here, we describe online implementations of these RNA detection tools that make these programs accessible to a wider range of research biologists. The tRNAscan-SE, snoscan and snoGPS servers are available at http://lowelab.ucsc.edu/tRNAscan-SE/, http://lowelab.ucsc.edu/snoscan/ and http://lowelab.ucsc.edu/snoGPS/, respectively.

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Metadata

Authors
Schattner, P., Brooks, A. N., & Lowe, T. M.
Venue
Nucleic Acids Research
Published
2005-07-01
Volume
33
Issue
Web Server
Pages
W686-W689
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2033713984
Cited by
2,295
References
15
FWCI
3.23
Type
journal article
Language
en
Open access
gold

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Schattner, P., Brooks, A. N., & Lowe, T. M. (2005). The tRNAscan-SE, snoscan and snoGPS web servers for the detection of tRNAs and snoRNAs. Nucleic Acids Research. https://doi.org/10.1093/nar/gki366

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