The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rad54: the Swiss Army knife of homologous recombination?
Open accessAbstract
Homologous recombination (HR) is a ubiquitous cellular pathway that mediates transfer of genetic information between homologous or near homologous (homeologous) DNA sequences. During meiosis it ensures proper chromosome segregation in the first division. Moreover, HR is critical for the tolerance and repair of DNA damage, as well as in the recovery of stalled and broken replication forks. Together these functions preserve genomic stability and assure high fidelity transmission of the genetic material in the mitotic and meiotic cell divisions. This review will focus on the Rad54 protein, a member of the Snf2-family of SF2 helicases, which translocates on dsDNA but does not display strand displacement activity typical for a helicase. A wealth of genetic, cytological, biochemical and structural data suggests that Rad54 is a core factor of HR, possibly acting at multiple stages during HR in concert with the central homologous pairing protein Rad51.
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Citations
Cites
Multiple pathways process stalled replication forks
Michel, B., Grompone, G., Florès, M.-J., & Bidnenko, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401586101 · Cited by 322 · cited 2×
“HR serves in the non-mutagenic tolerance of DNA damage, in the repair of complex DNA damage, such as single-stranded DNA (ssDNA) gaps, double-stranded DNA breaks (DSBs) and interstrand crosslinks, as well as in the recovery of stalled and collapsed replication forks (1,2).”
BackgroundRecombination factors of Saccharomyces cerevisiae
Sung, P., Trujillo, K. M., & Van Komen, S. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(00)00054-3 · Cited by 180
Cited by
Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., & Jasin, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.041 · Cited by 1,255
Regulation of Homologous Recombination in Eukaryotes
Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066
Self-citationThompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357
DNA Repair in Mammalian Cells: DNA double-strand break repair: how to fix a broken relationship
Pardo, B., Gómez-González, B., & Aguilera, A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8740-3 · Cited by 280
Póti, Á., Gyergyák, H., Németh, E., Rusz, O., Tóth, S., Kovácsházi, C., Chen, D., Szikriszt, B., Spisák, S., Takeda, S., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1867-0 · Cited by 116
Metadata
- Authors
- Heyer, W.-D., Li, X., Rolfsmeier, M., & Zhang, X.-P.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-08-25
- Volume
- 34
- Issue
- 15
- Pages
- 4115-4125
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2117502397
- Cited by
- 256
- References
- 2
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- gold
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- Heyer, W.-D., Li, X., Rolfsmeier, M., & Zhang, X.-P. (2006). Rad54: the Swiss Army knife of homologous recombination? Nucleic Acids Research. https://doi.org/10.1093/nar/gkl481
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