The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Delta Notch and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
Open accessAbstract
Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type of genes in Drosophila and they represent the primary targets of the Delta-Notch signaling pathway. Hairy-related factors control multiple steps of embryonic development and misregulation is associated with various defects. Hes and Hey genes (also called Hesr, Chf, Hrt, Herp or gridlock) encode transcriptional regulators of the basic helix-loop-helix class that mainly act as repressors. The molecular details of how Hes and Hey proteins control transcription are still poorly understood, however. Proposed modes of action include direct binding to N- or E-box DNA sequences of target promoters as well as indirect binding through other sequence-specific transcription factors or sequestration of transcriptional activators. Repression may rely on recruitment of corepressors and induction of histone modifications, or even interference with the general transcriptional machinery. All of these models require extensive protein-protein interactions. Here we review data published on protein-protein and protein-DNA interactions of Hairy-related factors and discuss their implications for transcriptional regulation. In addition, we summarize recent progress on the identification of potential target genes and the analysis of mouse models.
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Cites
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
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Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms
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Mutations in NOTCH1 cause aortic valve disease
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Signalling downstream of activated mammalian Notch
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HES and HERP families: Multiple effectors of the notch signaling pathway
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Control of endodermal endocrine development by Hes-1
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Hypoxia requires Notch signaling to maintain the undifferentiated cell state
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The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis
Benedito, R., Roca, C., Sörensen, I., Adams, S., Gossler, A., Fruttiger, M., & Adams, R. H. (2009) · Cell · doi:10.1016/j.cell.2009.03.025 · Cited by 1,107
Bray, S. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.94 · Cited by 1,012
Dynamic Ligand Discrimination in the Notch Signaling Pathway
Nandagopal, N., Santat, L. A., LeBon, L., Sprinzak, D., Bronner, M. E., & Elowitz, M. B. (2018) · Cell · doi:10.1016/j.cell.2018.01.002 · Cited by 322
The Notch signaling pathway as a mediator of tumor survival
Capaccione, K. M., & Pine, S. R. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt127 · Cited by 296
Notch and interacting signalling pathways in cardiac development, disease, and regeneration
MacGrogan, D., Münch, J., & de la Pompa, J. L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0100-2 · Cited by 287
Metadata
- Authors
- Fischer, A., & Gessler, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-25
- Volume
- 35
- Issue
- 14
- Pages
- 4583-4596
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2133885516
- Cited by
- 400
- References
- 152
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- gold
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