The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
Open accessAbstract
The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules. In this Survey and Summary, we review recent reports on delivery strategies, including conjugates of oligonucleotides with various ligands, as well as use of nanocarrier approaches. These are discussed in the context of intracellular trafficking pathways and issues regarding in vivo biodistribution of molecules and nanoparticles. Molecular-sized chemical conjugates and supramolecular nanocarriers each display advantages and disadvantages in terms of effective and nontoxic delivery. Thus, choice of an optimal delivery modality will likely depend on the therapeutic context.
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Cites
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Cited by
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In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
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Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides
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Self-citation
Metadata
- Authors
- Juliano, R., Alam, M. R., Dixit, V., & Kang, H.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-23
- Volume
- 36
- Issue
- 12
- Pages
- 4158-4171
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1994869675
- Cited by
- 429
- References
- 15
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Open access
- gold
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