The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions
Open accessAbstract
MicroRNAs (miRNAs) are noncoding RNAs with 18-26 nucleotides; they pair with target mRNAs to regulate gene expression and produce significant changes in various physiological and pathological processes. In recent years, the interaction between miRNAs and their target genes has become one of the mainstream directions for drug development. As a large-scale biological database that mainly provides miRNA-target interactions (MTIs) verified by biological experiments, miRTarBase has undergone five revisions and enhancements. The database has accumulated >2 200 449 verified MTIs from 13 389 manually curated articles and CLIP-seq data. An optimized scoring system is adopted to enhance this update's critical recognition of MTI-related articles and corresponding disease information. In addition, single-nucleotide polymorphisms and disease-related variants related to the binding efficiency of miRNA and target were characterized in miRNAs and gene 3' untranslated regions. miRNA expression profiles across extracellular vesicles, blood and different tissues, including exosomal miRNAs and tissue-specific miRNAs, were integrated to explore miRNA functions and biomarkers. For the user interface, we have classified attributes, including RNA expression, specific interaction, protein expression and biological function, for various validation experiments related to the role of miRNA. We also used seed sequence information to evaluate the binding sites of miRNA. In summary, these enhancements render miRTarBase as one of the most research-amicable MTI databases that contain comprehensive and experimentally verified annotations. The newly updated version of miRTarBase is now available at https://miRTarBase.cuhk.edu.cn/.
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Kolberg, L., Raudvere, U., Kuzmin, I., Adler, P., Vilo, J., & Peterson, H. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad347 · Cited by 1,673
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Integrated genomic and molecular characterization of cervical cancer
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miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
Huang, H.-Y., Lin, Y.-C.-D., Li, J., Huang, K.-Y., Shrestha, S., Hong, H.-C., Tang, Y., Chen, Y.-G., Jin, C.-N., Yu, Y., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz896 · Cited by 1,259
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Metadata
- Authors
- Hsu, S.-D., Tseng, Y.-T., Shrestha, S., Lin, Y.-L., Khaleel, A., Chou, C.-H., Chu, C.-F., Huang, H.-Y., Lin, C.-M., Ho, S.-Y., Jian, T.-Y., Lin, F.-M., Chang, T.-H., Weng, S.-L., Liao, K.-W., Liao, I.-E., Liu, C.-C., & Huang, H.-D.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-12-04
- Volume
- 42
- Issue
- D1
- Pages
- D78-D85
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2016106370
- Cited by
- 1,041
- References
- 99
- FWCI
- 34.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hsu, S.-D., Tseng, Y.-T., Shrestha, S., Lin, Y.-L., Khaleel, A., Chou, C.-H., Chu, C.-F., Huang, H.-Y., Lin, C.-M., Ho, S.-Y., Jian, T.-Y., Lin, F.-M., Chang, T.-H., Weng, S.-L., Liao, K.-W., Liao, I.-E., Liu, C.-C., & Huang, H.-D. (2014). miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions. Nucleic Acids Research. https://doi.org/10.1093/nar/gkt1266
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
