Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

Munde, M.; Wang, S.; Kumar, A.; Stephens, C. E.; Farahat, A. A.; Boykin, D. W.; Wilson, W. D.; Poon, G. M. K.

doi:10.1093/nar/gkt955

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

ETS transcription factors mediate a wide array of cellular functions and are attractive targets for pharmacological control of gene regulation. We report the inhibition of the ETS-family member PU.1 with a panel of novel heterocyclic diamidines. These diamidines are derivatives of furamidine (DB7…