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Cited by 1,473

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

The BioGRID interaction database: 2019 update

Open access
Oughtred, Rose, Stark, Chris, Breitkreutz, Bobby-Joe, Rust, Jennifer, Boucher, Lorrie, Chang, Christie, Kolas, Nadine, O’Donnell, Lara, Leung, Genie, McAdam, Rochelle, Zhang, Frederick, Dolma, Sonam, Willems, Andrew, Coulombe-Huntington, Jasmin, Chatr-aryamontri, Andrew, Dolinski, Kara, Tyers, Mike·2019·Nucleic Acids Research

Abstract

The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the curation and archival storage of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2018 (build 3.4.164), BioGRID contains records for 1 598 688 biological interactions manually annotated from 55 809 publications for 71 species, as classified by an updated set of controlled vocabularies for experimental detection methods. BioGRID also houses records for >700 000 post-translational modification sites. BioGRID now captures chemical interaction data, including chemical-protein interactions for human drug targets drawn from the DrugBank database and manually curated bioactive compounds reported in the literature. A new dedicated aspect of BioGRID annotates genome-wide CRISPR/Cas9-based screens that report gene-phenotype and gene-gene relationships. An extension of the BioGRID resource called the Open Repository for CRISPR Screens (ORCS) database (https://orcs.thebiogrid.org) currently contains over 500 genome-wide screens carried out in human or mouse cell lines. All data in BioGRID is made freely available without restriction, is directly downloadable in standard formats and can be readily incorporated into existing applications via our web service platforms. BioGRID data are also freely distributed through partner model organism databases and meta-databases.

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Metadata

Authors
Oughtred, R., Stark, C., Breitkreutz, B.-J., Rust, J., Boucher, L., Chang, C., Kolas, N., O’Donnell, L., Leung, G., McAdam, R., Zhang, F., Dolma, S., Willems, A., Coulombe-Huntington, J., Chatr-aryamontri, A., Dolinski, K., & Tyers, M.
Venue
Nucleic Acids Research
Published
2018-11-24
Volume
47
Issue
D1
Pages
D529-D541
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2917858269
Cited by
1,473
References
20
FWCI
55.72
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The BioGRID interaction database: 2019 update. https://app.cochat.ai/papers/10.1093/nar/gky1079
The paper
Oughtred, R., Stark, C., Breitkreutz, B.-J., Rust, J., Boucher, L., Chang, C., Kolas, N., O’Donnell, L., Leung, G., McAdam, R., Zhang, F., Dolma, S., Willems, A., Coulombe-Huntington, J., Chatr-aryamontri, A., Dolinski, K., & Tyers, M. (2019). The BioGRID interaction database: 2019 update. Nucleic Acids Research. https://doi.org/10.1093/nar/gky1079

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