The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
CancerSEA: a cancer single-cell state atlas
Open accessAbstract
High functional heterogeneity of cancer cells poses a major challenge for cancer research. Single-cell sequencing technology provides an unprecedented opportunity to decipher diverse functional states of cancer cells at single-cell resolution, and cancer scRNA-seq datasets have been largely accumulated. This emphasizes the urgent need to build a dedicated resource to decode the functional states of cancer single cells. Here, we developed CancerSEA (http://biocc.hrbmu.edu.cn/CancerSEA/ or http://202.97.205.69/CancerSEA/), the first dedicated database that aims to comprehensively explore distinct functional states of cancer cells at the single-cell level. CancerSEA portrays a cancer single-cell functional state atlas, involving 14 functional states (including stemness, invasion, metastasis, proliferation, EMT, angiogenesis, apoptosis, cell cycle, differentiation, DNA damage, DNA repair, hypoxia, inflammation and quiescence) of 41 900 cancer single cells from 25 cancer types. It allows querying which functional states are associated with the gene (or gene list) of interest in different cancers. CancerSEA also provides functional state-associated PCG/lncRNA repertoires across all cancers, in specific cancers, and in individual cancer single-cell datasets. In summary, CancerSEA provides a user-friendly interface for comprehensively searching, browsing, visualizing and downloading functional state activity profiles of tens of thousands of cancer single cells and the corresponding PCGs/lncRNAs expression profiles.
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Cited by
Sun, D., Wang, J., Han, Y., Dong, X., Ge, J., Zheng, R., Shi, X., Wang, B., Li, Z., Ren, P., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1020 · Cited by 1,082
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Han, Y., Wang, Y., Dong, X., Sun, D., Liu, Z., Yue, J., Wang, H., Li, T., & Wang, C. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac959 · Cited by 630
Applications of single-cell sequencing in cancer research: progress and perspectives
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CHETAH: a selective, hierarchical cell type identification method for single-cell RNA sequencing
de Kanter, J. K., Lijnzaad, P., Candelli, T., Margaritis, T., & Holstege, F. C. P. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz543 · Cited by 285
Metadata
- Authors
- Yuan, H., Yan, M., Zhang, G., Liu, W., Deng, C., Liao, G., Xu, L., Luo, T., Yan, H., Long, Z., Shi, A., Zhao, T., Xiao, Y., & Li, X.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-10-17
- Volume
- 47
- Issue
- D1
- Pages
- D900-D908
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2897044695
- Cited by
- 1,041
- References
- 33
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yuan, H., Yan, M., Zhang, G., Liu, W., Deng, C., Liao, G., Xu, L., Luo, T., Yan, H., Long, Z., Shi, A., Zhao, T., Xiao, Y., & Li, X. (2019). CancerSEA: a cancer single-cell state atlas. Nucleic Acids Research. https://doi.org/10.1093/nar/gky939
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