The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation
Abstract
Homopyrimidine oligodeoxyribonucleotides with EDTA⋅Fe attached at a single position bind the corresponding homopyrimidine-homopurine tracts within large double-stranded DNA by triple helix formation and cleave at that site. Oligonucleotides with EDTA⋅Fe at the 5′ end cause a sequence specific double strand break. The location and asymmetry of the cleavage pattern reveal that the homopyrimidine-EDTA probes bind in the major groove parallel to the homopurine strand of Watson-Crick double helical DNA. The sequence-specific recognition of double helical DNA by homopyrimidine probes is sensitive to single base mismatches. Homopyrimidine probes equipped with DNA cleaving moieties could be useful tools for mapping chromosomes.
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Citations
Cites
Echinomycin Binding Sites on DNA
Van Dyke, M. M., & Dervan, P. B. (1984) · Science · doi:10.1126/science.6089341 · Cited by 218
Self-citation
Cited by
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Pogozelski, W. K., & Tullius, T. D. (1998) · Chemical Reviews · doi:10.1021/cr960437i · Cited by 1,018
Triplex DNA Nanostructures: From Basic Properties to Applications
Hu, Y., Cecconello, A., Idili, A., Ricci, F., & Willner, I. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701868 · Cited by 336
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Leung, C., Chan, D. S., Ma, V. P., & Ma, D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21266 · Cited by 58
Metadata
- Authors
- Moser, H. E., & Dervan, P. B.
- Venue
- Science
- Published
- 1987-10-30
- Volume
- 238
- Issue
- 4827
- Pages
- 645-650
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2133918133
- Cited by
- 1,284
- References
- 1
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
