Higher plasma interleukin-18 levels associated with poor quality of sleep in peritoneal dialysis patients
Abstract
BACKGROUND: Sleep disorders are prevalent in patients with end-stage renal disease. Increasing evidence suggests that cytokines are involved in the regulation of sleep and wakefulness. The purpose of this study was to examine the relationship between quality of sleep and plasma interleukin-18 levels in peritoneal dialysis patients. METHODS: Plasma interleukin-18 levels were determined by the enzyme-linked immunosorbent assay (ELISA) methodology in 57 peritoneal dialysis patients. Quality of sleep was measured using the Pittsburgh Sleep Quality Index. Demographic and routine laboratory data were recorded. RESULTS: In our cohort, the poor sleepers had higher plasma interleukin-18 levels (559.16 +/- 261.22 pg/ml vs 397.49 +/- 191.81 pg/ml, P = 0.01). The plasma interleukin-18 level was positively correlated with the Pittsburgh Sleep Quality Index score (r = 0.286, P = 0.031), that is, there was a positive association between higher plasma interleukin-18 levels and poorer quality of sleep. CONCLUSION: This study demonstrates that interleukin-18 may be involved in sleep disorders in end-stage renal disease patients. Higher plasma interleukin-18 levels are associated with poorer quality of sleep in peritoneal dialysis patients. Whether a cause-and-effect relationship exists between interleukin-18 and quality of sleep deserves further study.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Excessive cytokine levels are associated with disrupted sleep.
“Although cytokine secretion induced by low-level exposure of immune cells to bacterial cell wall components contributes to normal sleep patterns, excessive cytokine levels are associated with disrupted sleep.26”
From The Gut Microbiome and the Brain (2014) · cites this paper as [26]
Cites
Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea
Minoguchi, K., Yokoe, T., 田崎, 俊., Minoguchi, H., Tanaka, A., Oda, N., Okada, S., Ohta, S., Naito, H., & Adachi, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1652oc · Cited by 421 · see citing works
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393 · see citing works
Kimmel, P. L., & Peterson, R. A. (2005) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2005.18209.x · Cited by 258 · see citing works
The Pittsburgh Sleep Quality Index (PSQI)
Smyth, C. A. (1999) · Journal of Gerontological Nursing · doi:10.3928/0098-9134-19991201-10 · Cited by 227 · see citing works
Habenular and interpeduncularis nuclei: shared components in multiple-function networks.
Klemm, W. R. (2004) · PubMed · Cited by 153 · see citing works
Sleep disorders in patients on continuous ambulatory peritoneal dialysis.
Stepanski, E. J., Faber, M. D., Zorick, F. J., et al. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v62192 · Cited by 151 · see citing works
Clinical relevance of cytokine production in hemodialysis
Pertosa, G. B., Grandaliano, G., Gesualdo, L., & Schena, F. P. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07613.x · Cited by 146 · see citing works
Chen, W.-C., Lim, P., Wu, W., Chiu, H.-C., Chen, C., Kuo, H.-Y., Tsai, T.-W., Chien, P.-I., Su, Y.-J., Su, Y.-L., et al. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2006.04.079 · Cited by 119 · see citing works
Self-citationRespiratory Considerations in the Patient With Renal Failure
Pierson, D. J. (2006) · Respiratory Care · doi:10.4187/respcare.06510413 · Cited by 113 · see citing works
Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis
Tschoeke, S. K., Oberholzer, A., & Moldawer, L. L. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000208356.05575.16 · Cited by 102 · see citing works
Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS
Sugama, S., Cho, B. P., Baker, H., Joh, T. H., Lucero, J., & Conti, B. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03363-2 · Cited by 102 · see citing works
Interleukin-18 promotes sleep in rabbits and rats
Kubota, T., Fang, J., Brown, R. A., & Krueger, J. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r828 · Cited by 69 · see citing works
Interleukin‐18 and CD30 serum levels in patients with moderate‐severe depression
Merendino, R. A., Rosa, A. E. D., Pasquale, G. D., Minciullo, P. L., Mangraviti, C., Costantino, A., Ruello, A., & Gangemi, S. (2002) · Mediators of Inflammation · doi:10.1080/096293502900000131 · Cited by 68 · see citing works
Plasma Interleukin-18 Levels in Patients with Psychiatric Disorders
Kokai, M., Kashiwamura, S.-I., Okamura, H., Ohara, K., & Morita, Y. (2002) · Journal of Immunotherapy · doi:10.1097/00002371-200203001-00011 · Cited by 67 · see citing works
Interleukin-18 is a strong predictor of hospitalization in haemodialysis patients
Chiang, C. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh475 · Cited by 47 · see citing works
Self-citationCytokine Production in Haemodialysis
Memoli, B. (1999) · Blood Purification · doi:10.1159/000014387 · Cited by 45 · see citing works
Lui, S. L., Ng, F., & Lo, W. K. (2002) · Peritoneal Dialysis International · doi:10.1177/089686080202200606 · Cited by 43 · see citing works
Relationship between sleep complaints and proinflammatory cytokines in haemodialysis patients
Erten, Y., Köktürk, O., Yüksel, A., Elbeğ, Ş., Çiftçi, T. U., Paşaoğlu, H., OZKAN, S., Bali, M., ARINSOI, T., & Sindel, Ş. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00418.x · Cited by 42 · see citing works
Involvement of Interleukin-18 in Patients on Maintenance Haemodialysis
Gangemi, S., Mallamace, A., Minciullo, P. L., Santoro, D., Merendino, R. A., Savica, V., & Bellinghieri, G. (2002) · American Journal of Nephrology · doi:10.1159/000065269 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Chen, H.-Y., Cheng, I.-C., Pan, Y.-J., Chiu, Y.-L., Hsu, S.-P., Pai, M.-F., Yang, J.-Y., Peng, Y.-S., Tsai, T.-J., & Wu, K.-D. (2011) · Kidney International · doi:10.1038/ki.2011.151 · Cited by 140 · see citing works
Self-citationChen, H.-Y., Chiang, C.-K., Wang, H.-H., Hung, K.-Y., Lee, Y.-J., Peng, Y.-S., Wu, K.-D., & Tsai, T.-J. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.03.012 · Cited by 111 · see citing works
Self-citationChiu, Y.-L., Chuang, Y.-F., Fang, K.-C., Liu, S.-K., Chen, H.-Y., Yang, J.-Y., Pai, M.-F., Peng, Y.-S., Wu, K.-D., & Tsai, T.-J. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn439 · Cited by 104 · see citing works
Self-citationREM sleep deprivation increases the expression of interleukin genes in mice hypothalamus
Kang, W. S., Park, H. J., Chung, J.-H., & Kim, J. W. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.050 · Cited by 33 · see citing works
Fornadi, K., Lindner, A., Czira, M. E., Szentkiralyi, A., Lazar, A. S., Zoller, R., Turanyi, C. Z., Veber, O., Novak, M., Mucsi, I., et al. (2012) · International Urology and Nephrology · doi:10.1007/s11255-011-0095-7 · Cited by 32 · see citing works
- Authors
- Yang, J.-Y., Huang, J.-W., Chiang, C.-K., Pan, C.-C., Wu, K.-D., Tsai, T.-J., & Chen, W.-Y.
- Affiliations
- National Taiwan University (TW)
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08-25
- Volume
- 22
- Issue
- 12
- Pages
- 3606-3609
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2123934952
- Cited by
- 38
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2017: 1 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- IL-18, sleep quality, sleep disorders, peritoneal dialysis, end-stage renal disease, cytokines, Pittsburgh Sleep Quality Index, plasma cytokines
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Peritoneal Dialysis, Quality of Life, Sleep, Interleukin-18
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
