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Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients
Abstract
Purpose In patients on dialysis, the results of studies examining the association between sleep disorders and inflammation are controversial. We assessed the association between inflammatory markers and different sleep disorders in a large sample of kidney transplant recipients.Methods Cross-sectional study of 100 randomly selected kidney transplant patients who underwent one-night polysomnography ("sleep disorders evaluation in patients after kidney transplantation study") to diagnose obstructive sleep apnea (OSA) and periodic limb movements in sleep (PLMS). Athens Insomnia Scale (AIS) was utilized to assess the prevalence of insomnia. Sociodemographic information and data about medication, comorbidity and laboratory parameters were collected. Levels of inflammatory markers, such as C-reactive protein, serum albumin, white blood cell count, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), were measured.Results The mean age was 51 ± 13 years, 43% were women, and the prevalence of diabetes was 19%. We found no significant difference in the levels of inflammatory markers between patients with versus without OSA and PLMS. Apnea-hypopnea index showed a significant association with white blood cell count (ρ = 0.23), and weak (ρ < |0.15|), non-significant correlation with the other inflammatory markers. PLM index showed weak (ρ < |0.15|), non-significant correlation with all markers of inflammation. The serum IL-6 level was significantly higher in patients with insomnia (AIS ≥ 10) than in non-insomniacs [median (IQR): 3.2(2.6-5.1) vs. 1.7(1.2-2.9) ng/l; P = 0.009]. The levels of other inflammatory markers were similar between insomniacs and non-insomniacs.Conclusions We did not find any association between the presence of objectively assessed sleep disorders and inflammatory markers in kidney transplant patients.
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T-cell activation and cytokine production, in particular IFN-γ and TNF, are thought to be responsible for the clinical symptoms of infectious mononucleosis.
“T-cell activation and cytokine production, in particular IFN-γ and TNF, are thought to be responsible for the clinical symptoms of infectious mononucleosis (21, 194, 581).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [194]
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“The link between sleep disturbances and immune measures has been also investigated in depression (124, 227, 393, 532), schizophrenia (176), alcohol dependence (462), hemodialysis (107, 458), organ transplantation (193), pregnancy (55, 409), cervical cancer risk (491), and diabetes (548), with most studies reporting a…”
BackgroundSleep duration, cardiovascular disease, and proinflammatory biomarkers
Grandner, M., Sands-Lincoln, Pak, & Garland (2013) · Nature and Science of Sleep · doi:10.2147/nss.s31063 · Cited by 246
Smagula, S. F., Stone, K. L., Redline, S., Ancoli-Israel, S., Barrett-Connor, E., Lane, N. E., Orwoll, E. S., & Cauley, J. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000312 · Cited by 116
Metadata
- Authors
- Fornadi, K., Lindner, A., Czira, M. E., Szentkiralyi, A., Lazar, A. S., Zoller, R., Turanyi, C. Z., Veber, O., Novak, M., Mucsi, I., & Molnar, M. Z.
- Affiliations
- Semmelweis University (HU)
- Corresponding author
- Molnar, Miklos Z.
- Venue
- International Urology and Nephrology
- Published
- 2011-12-06
- Volume
- 44
- Issue
- 2
- Pages
- 607-617
- ISSN
- 0301-1623 (ISSN-L)
- 1573-2584
- OpenAlex
- W2085070206
- Cited by
- 32
- References
- 51
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Urology and Nephrology (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep disorders, inflammatory markers, kidney transplant recipients, obstructive sleep apnea, periodic limb movements in sleep, insomnia, interleukin-6, TNF-α, C-reactive protein, apnea-hypopnea index, polysomnography
- MeSH terms
- C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Hungary, Inflammation, Kidney Failure, Chronic, Male, Middle Aged, Retrospective Studies, Risk Factors, Severity of Illness Index, Sleep Wake Disorders, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Prevalence, Kidney Transplantation, Polysomnography
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