Renal sympathetic nerve ablation for the treatment of difficult-to-control or refractory hypertension in a haemodialysis patient
Open accessAbstract
Haemodialysis patients show sympathetic hyperactivity. Hyperactivation of the sympathetic nervous system aggravates hypertension and it is related to left ventricular hypertrophy, heart failure, arrhythmias and atherogenesis. We report the first use of renal sympathetic nerve ablation for correction of uncontrolled hypertension in an end-stage renal disease patient on maintenance dialysis. We observed a progressive and sustained reduction of systemic blood pressure. Our case demonstrates the safety, the feasibility and the efficacy of this procedure. These findings suggest, however, that further clinical trials are needed into renal nerve radiofrequency ablation therapy for the treatment of hypertension and for the improvement of cardiovascular prognosis in this high-risk patient group.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Small studies and case reports show that renal denervation reduces blood pressure and is safe in patients with kidney failure on haemodialysis.
“a small clinical trial in 24 patients with kidney failure on haemodialysis confirmed the safety of the procedure in these patients and demonstrated that RDN resulted in significant reductions in DBP and SBP that persisted for at least 12 months64.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [120]
The Abstract reports lower systolic and diastolic blood pressure one month after renal denervation in a single haemodialysis patient. It describes a case report, not a 24-patient clinical trial, and does not establish procedural safety or blood-pressure reductions lasting at least 12 months. (LLM, conf=0.90)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works
Sympathetic Overactivity in Patients with Chronic Renal Failure
Converse, R. L., Jacobsen, T. N., Toto, R. D., Jost, C. M. T., Cosentino, F., Fouad-Tarazi, F., & Victor, R. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272704 · Cited by 1,132 · see citing works
Sympathetic hyperactivity in chronic kidney disease
Blankestijn, P. J. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh242 · Cited by 58 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity
Canale, M. P., di Villahermosa, S. M., Martino, G., Rovella, V., Noce, A., LORENZO, A. D., & Daniele, N. D. (2013) · International Journal of Endocrinology · doi:10.1155/2013/865965 · Cited by 219 · see citing works
Sympathetic Nervous System Function and Dysfunction in Chronic Hemodialysis Patients
Rubinger, D., Backenroth, R., & Sapoznikov, D. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12093 · Cited by 101 · see citing works
Effect of renal denervation on kidney function in patients with chronic kidney disease
Hering, D., Marusic, P., Duval, J., Sata, Y., Head, G. A., Denton, K. M., Burrows, S., Walton, A. S., Esler, M. D., & Schlaich, M. P. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.01.047 · Cited by 77 · see citing works
Intradialysis Hypertension in End-Stage Renal Disease Patients
Georgianos, P. I., Sarafidis, P. A., & Zoccali, C. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05858 · Cited by 62 · see citing works
Sympathetic Hyperactivity in Chronic Kidney Disease: Pathophysiology and (New) Treatment Options
Vink, E. E., de Jager, R. L., & Blankestijn, P. J. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0328-5 · Cited by 50 · see citing works
Hering, D., Esler, M., & Schlaich, M. P. (2013) · EuroIntervention · doi:10.4244/eijv9sra22 · Cited by 45 · see citing works
Ott, C., Schmid, A., Ditting, T., Sobotka, P. A., Veelken, R. A., Uder, M., & Schmieder, R. E. (2012) · Journal of Clinical Hypertension · doi:10.1111/jch.12017 · Cited by 44 · see citing works
Renal nerves in physiology, pathophysiology and interoception
Evans, L. C., Dayton, A., & Osborn, J. W. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00893-3 · Cited by 46 · see citing works
Vink, E. E., Verloop, W. L., Siddiqi, L., van Schelven, L. J., Oey, P. L., & Blankestijn, P. J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.06.021 · Cited by 34 · see citing works
Sympathetic activation secondary to chronic kidney disease
de Beus, E., de Jager, R. L., Joles, J. A., Grassi, G. M., & Blankestijn, P. J. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000210 · Cited by 32 · see citing works
Ott, C., Schmid, A., Ditting, T., Veelken, R., Uder, M., & Schmieder, R. (2019) · Clinical and Experimental Nephrology · doi:10.1007/s10157-019-01697-7 · Cited by 27 · see citing works
Mauriello, A., Rovella, V., Anemona, L., Servadei, F., Giannini, E., Bove, P., Anselmo, A., Melino, G., & Daniele, N. D. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002426 · Cited by 30 · see citing works
Persu, A., Renkin, J. P., Asayama, K., O'Brien, E. T., & Staessen, J. A. (2013) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.13.52 · Cited by 27 · see citing works
Sata, Y., & Schlaich, M. P. (2016) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248415624156 · Cited by 22 · see citing works
Hoye, N. A., Wilson, L. C., WILKINS, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.04.012 · Cited by 16 · see citing works
Patient Selection for Renal Denervation in Hypertensive Patients: What Makes a Good Candidate?
Li, S., & Phillips, J. K. (2022) · Vascular Health and Risk Management · doi:10.2147/vhrm.s270182 · Cited by 14 · see citing works
Renal denervation in chronic kidney disease
Blankestijn, P. J., & Joles, J. A. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.143 · Cited by 12 · see citing works
Renal Denervation in End-Stage Renal Disease: Current Evidence and Perspectives
Scalise, F., Quarti‐Trevano, F., Toscano, E., Sorropago, A., Vanoli, J., & Grassi, G. M. (2024) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-023-00621-1 · Cited by 11 · see citing works
Renal denervation in dialysis patients: long-term outcomes in a real-world setting
Gangemi, C., Gambaro, A., Ortalda, V., Tavella, D., Caletti, C., Fezzi, S., Bianco, B., Tomi, E. D., Gambaro, G., Ribichini, F. L., et al. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf149 · Cited by 10 · see citing works
Weber, T., Zweiker, R., Watschinger, B., Grüner, P., Koppelstätter, C., Brandt, M. C., Horina, J. H., Brussee, H., Hohenstein, K., Lambert, T., et al. (2012) · Wiener klinische Wochenschrift · doi:10.1007/s00508-012-0257-3 · Cited by 10 · see citing works
Mazza, A., Dell’Avvocata, F., Torin, G., Bulighin, F., Battaglia, Y., & Fiorini, F. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01264-2 · Cited by 9 · see citing works
Pua, U., Tan, C. H., Ho, H. H., Tan, J. K. B., & Ong, P. J. L. (2014) · European Radiology · doi:10.1007/s00330-014-3392-6 · Cited by 9 · see citing works
Renal denervation of the native kidneys for drug-resistant hypertension after kidney transplantation
Dobrowolski, L. C., Bemelman, F. J., ten Berge, I. J. M., van den Born, B. H., Reekers, J. A., & Krediet, C. T. P. (2014) · Clinical Kidney Journal · doi:10.1093/ckj/sfu134 · Cited by 9 · see citing works
Okamura, K., Shirai, K., Okuda, T., & Urata, H. (2017) · Internal Medicine · doi:10.2169/internalmedicine.9059-17 · Cited by 8 · see citing works
Oosugi, K., Fujimoto, N., Dohi, K., Machida, H., Onishi, K., Takeuchi, M., Nomura, S., Takeuchi, H., Nobori, T., & Ito, M. (2013) · Hypertension Research · doi:10.1038/hr.2013.123 · Cited by 7 · see citing works
Pietilä-Effati, P. M., Salmela, A. K., & Koistinen, M. J. (2018) · American Journal of Case Reports · doi:10.12659/ajcr.909820 · Cited by 7 · see citing works
Future of catheter-based renal denervation: key issues to solve
Kimura, G. (2013) · Hypertension Research · doi:10.1038/hr.2013.31 · Cited by 4 · see citing works
Daniele, N. D., Rovella, V., Violo, L., Francesco, M. D., Sperandio, M., Spinelli, A., Tesauro, M., Romeo, F., & Simonetti, G. (2014) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000131 · Cited by 4 · see citing works
Self-citationGossios, T. D., Ziakas, A., Doumas, M. N., Katsiki, N., Petroglou, D., Κouparanis, A., Lillis, L., & Karvounis, H. I. (2014) · Angiology · doi:10.1177/0003319713517738 · Cited by 3 · see citing works
Endovascular renal denervation: a novel sympatholytic with relevance to chronic kidney disease
Hoye, N. A., Baldi, J. C., Putt, T. L., Schollum, J. B., Wilkins, G. T., & Walker, R. J. (2013) · Clinical Kidney Journal · doi:10.1093/ckj/sft130 · Cited by 3 · see citing works
Technical aspects of renal denervation in end-stage renal disease patients with challenging anatomy
Spinelli, A., Ros, V. D., Morosetti, D., D'Onofrio, S., Rovella, V., Daniele, N. D., & Simonetti, G. (2014) · Diagnostic and Interventional Radiology · doi:10.5152/dir.2013.13408 · Cited by 3 · see citing works
Self-citationWang, Y., Denton, K. M., & Golledge, J. (2013) · Hypertension Research · doi:10.1038/hr.2013.82 · Cited by 3 · see citing works
Therapeutical Approach to Arterial Hypertension - Current State of the Art
Radosavljević, M., Vučević, D. B., Samardžić, J., Radenković, M., & Radosavljević, T. S. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673274823231220063652 · Cited by 2 · see citing works
Казакова, И. А., & Ievlev, E. N. (2020) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20202306291 · Cited by 2 · see citing works
La dénervation rénale endovasculaire dans le traitement de l’hypertension artérielle résistante
Monge, M., Lorthioir, A., Bobrie, G., Briet, M. B., Plouin, P., Sapoval, M. R., & Azizi, M. (2013) · Journal des Maladies Vasculaires · doi:10.1016/j.jmv.2013.09.002 · Cited by 1 · see citing works
Prkačin, I., Ćorić-Martinović, V., Bulum, T., Cavrić, G., Dobrota, V. Đ., & Vidjak, V. (2015) · PubMed · Cited by 1 · see citing works
The Endpoint on Measuring the Clinical Effects of Renal Denervation: What Are the Best Surrogates
Sobotka, P. A., Harrison, D. G., & Fudim, M. (2014) · Springer eBooks · doi:10.1007/978-1-4471-5223-1_4 · Cited by 1 · see citing works
Renal denervation in a patient with Alport syndrome and rejected renal allograft
Raju, N., Vincent, L., Yalagudri, S. D., Das, B., & Ravikishore, A. G. (2015) · Indian Heart Journal · doi:10.1016/j.ihj.2015.12.004 · Cited by 1 · see citing works
Cardiovascular effects of irbesartan in haemodialysis patients
Peters, C. D. (2013) · Cited by 1 · see citing works
Kimura, G. (2013) · Hypertension Research · doi:10.1038/hr.2013.117
La denervazione renale transcatetere: il ruolo del nefrologo
Pieruzzi, F. (2018) · Giornale di Clinica Nefrologica e Dialisi · doi:10.33393/gcnd.2012.1165
Effects of Renal Denervation on Chronic Kidney Disease
Vrdoljak, A., Premužić, V., & Jelaković, B. (2016) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-34141-5_19
Nishikawa, M., Miyagawa, K., Tamada, N., Maekawa, K., & Miki, T. (2015) · Nihon Toseki Igakkai Zasshi · doi:10.4009/jsdt.48.303
Renal Denervation: Current Opinions and Practice
Schlaich, M. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-56042-7_41
Renal artery sympathetic nerve radiofrequency denervation
Bartuś, K., Sadowski, J., Kapelak, B., Litwinowicz, R. A., Podolec, J., Bartuś, M., Dziewierz, A., Bartuś, S., Zajdel, W., & Lakkireddy, D. (2017) · Kardiologia Polska · doi:10.5603/kp.a2017.0100
Renal Denervation and Nephrologist's Role
Pieruzzi, F. (2012) · Giornale di Techniche Nefrologiche e Dialitiche · doi:10.1177/039493621202400415
The Role of Renal Denervation in the Management of Hypertension
Svetkey, L. P., & Tyson, C. C. (2013)
Weber, T., Zweiker, R., Watschinger, B., Grüner, P., Koppelstätter, C., Mc, B., Jh, H., Brussee, H., Hohenstein, K., Lambert, T., et al. (2013) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Endpoints for Clinical Effects of Renal Denervation: What Is the Best Surrogate?
Friede, K. A., Fudim, M., & Sobotka, P. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_6
- Authors
- Di Daniele, N., De Francesco, M., Violo, L., Spinelli, A., & Simonetti, G.
- Affiliations
- University of Rome Tor Vergata (IT)
- Venue
- Nephrology Dialysis Transplantation
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-29
- Volume
- 27
- Issue
- 4
- Pages
- 1689-1690
- ISSN
- 0931-0509 (ISSN-L)
- 1460-2385
- OpenAlex
- W2114547337
- Cited by
- 49
- References
- 3
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 14 · 2012: 4
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nephrology Dialysis Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- resistant hypertension, hemodialysis, end-stage renal disease, sympathetic hyperactivity, radiofrequency ablation, blood pressure reduction, cardiovascular risk
- MeSH terms
- Adult, Renal Dialysis, Humans, Hypertension, Kidney Failure, Chronic, Prognosis, Renal Artery, Sympathectomy, Sympathetic Nervous System, Catheter Ablation, Blood Pressure Monitoring, Ambulatory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
