The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity
Open accessAbstract
An accurate, nonsurgical diagnostic test for brain tumors is currently unavailable, and the methods of monitoring disease progression are not fully reliable. MicroRNA profiling of biological fluids has recently emerged as a diagnostic tool for several pathologic conditions. Here we tested whether microRNA profiling of cerebrospinal fluid (CSF) enables detection of glioblastoma, discrimination between glioblastoma and metastatic brain tumors, and reflects disease activity. We determined CSF levels of several cancer-associated microRNAs for 118 patients diagnosed with different types of brain cancers and nonneoplastic neuropathologies by quantitative reverse transcription PCR analysis. The levels of miR-10b and miR-21 are found significantly increased in the CSF of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions. Members of the miR-200 family are highly elevated in the CSF of patients with brain metastases but not with any other pathologic conditions, allowing discrimination between glioblastoma and metastatic brain tumors. Quantification of as few as 7 microRNAs in CSF enables differential recognition of glioblastoma and metastatic brain cancer using computational machine learning tools (Support Vector Machine) with high accuracy (91%-99%) on a test set of samples. Furthermore, we show that disease activity and treatment response can be monitored by longitudinal microRNA profiles in the CSF of glioblastoma and non-small cell lung carcinoma patients. This study demonstrates that microRNA-based detection of brain malignancies can be reliably performed and that microRNAs in CSF can serve as biomarkers of treatment response in brain cancers.
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways
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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
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Extensive modulation of a set of microRNAs in primary glioblastoma
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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
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Self-citationJackman, D. M., Holmes, A. J., Lindeman, N., Wen, P. Y., Kesari, S., Borras, A. M., Bailey, C., de Jong, F., Jänne, P. A., & Johnson, B. E. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.6126 · Cited by 260
Self-citationDownregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo
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Cited by
MicroRNAome genome: A treasure for cancer diagnosis and therapy
Berindan‐Neagoe, I., Monroig, P. D. C., Pasculli, B., & Calin, G. A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21244 · Cited by 522
Shi, R., Wang, P.-Y., Li, X.-Y., Chen, J.-X., Li, Y., Zhang, X.-Z., Zhang, C.-G., Jiang, T., Li, W.-B., Ding, W., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4699 · Cited by 285
Li, Q., Li, B., Li, Q., Wei, S., He, Z., Huang, X., Wang, L., Xia, Y., Xu, Z., Li, Z., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0928-8 · Cited by 219
Müller, M., Kuiperij, H. B., Claassen, J. A., Küsters, B., & Verbeek, M. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.005 · Cited by 205
Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., Kolsteeg, C.-J., Dusoswa, S. A., Ting, D. T., Hickman, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.036 · Cited by 199
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Metadata
- Authors
- Teplyuk, N. M., Mollenhauer, B., Gabriely, G., Giese, A., Kim, E., Smolsky, M., Kim, R. Y., Saria, M. G., Pastorino, S., Kesari, S., & Krichevsky, A. M.
- Venue
- Neuro-Oncology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-04
- Volume
- 14
- Issue
- 6
- Pages
- 689-700
- ISSN
- 1522-8517 (ISSN-L)
- 1523-5866
- OpenAlex
- W2125736017
- Cited by
- 302
- References
- 8
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Teplyuk, N. M., Mollenhauer, B., Gabriely, G., Giese, A., Kim, E., Smolsky, M., Kim, R. Y., Saria, M. G., Pastorino, S., Kesari, S., & Krichevsky, A. M. (2012). MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro-Oncology. https://doi.org/10.1093/neuonc/nos074
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