Extensive modulation of a set of microRNAs in primary glioblastoma
Abstract
MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles in animals and plants by repressing translation or cleaving RNA transcripts. The specific modulation of several microRNAs has been recently associated to some forms of human cancer, suggesting that these short molecules may represent a new class of genes involved in oncogenesis. In our study, we examined by microarray the global expression levels of 245 microRNAs in glioblastoma multiforme, the most frequent and malignant of primary brain tumors. The analysis of both glioblastoma tissues and glioblastoma cell lines allowed us to identify a group of microRNAs whose expression is significantly altered in this tumor. The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma.
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miR-21 expression is increased in glioblastoma, head and neck carcinomas, ovarian cancer, B-cell lymphoma, hepatocellular, and cervical carcinoma.
“Further miRNA profiling in tumor samples and cancer cell lines show increased miR-21 expression in glioblastoma (Chan et al., 2005; Ciafre et al., 2005), head and neck carcinomas (Tran et al., 2007), ovarian cancer (Iorio et al., 2007), B-cell lymphoma (Lawrie et al., 2007), hepatocellular (Meng et al., 2007), and cervical carcinoma (Lui et al., 2007).”
From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Ciafre et al., 2005
miR-21 plays an oncogenic role in various cancers, especially glioblastoma (GBM).
“miR-21 is one of the important miRNAs that play an oncogenic role in various cancers, especially in GBM (10).”
From Functional interaction between miR-505-3p and miR-21 contributes to GBM suppression (2026) · cites this paper as [10]
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Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
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“Further miRNA profiling in tumor samples and cancer cell lines showed increased miR-21 expression in glioblastoma (Chan et al., 2005; Ciafre et al., 2005), head and neck carcinomas (Tran et al.”
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Functional interaction between miR-505-3p and miR-21 contributes to GBM suppression
Banadkooki, M. Z., Soltani, B. M., & Mowla, S. J. (2026) · Scientific Reports · doi:10.1038/s41598-026-59926-5
“To date, the harnessing of miR-21 by miR-505-3p has not been investigated, and the study conducted is the first to investigate this relationship in GBM cell lines.”
Influential
- Authors
- Ciafrè, S. A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.-G., Sabatino, G., Negrini, M., Maira, G., Croce, C. M., & Farace, M. G.
- Affiliations
- University of Rome Tor Vergata (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Ferrara (IT)
- Thomas Jefferson University (US)
- Corresponding author
- Ciafrè, S.A.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 334
- Issue
- 4
- Pages
- 1351-1358
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2144753743
- Cited by
- 1,096
- References
- 2
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 19 · 2023: 25 · 2022: 24 · 2021: 40 · 2020: 36 · 2019: 31 · 2018: 29 · 2017: 53 · 2016: 50 · 2015: 88 · 2014: 65 · 2013: 104 · 2012: 82
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- National Institutes of Health (4p01ca081534-16)
- National Cancer Institute (R01CA083698, P01 CA81534, P01-CA76259, P01CA076259, CA083698)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- microRNA, glioblastoma, miR-221, miR-128, miR-181a, miR-181b, miR-181c, miRNA expression profiling, glioblastoma cell lines, non-coding RNA regulation, carcinogenesis
- MeSH terms
- Brain, Cell Differentiation, Female, Glioblastoma, Humans, Male, Reference Values, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Line, Tumor
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