The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Long-Term Clinical and Angiographic Outcomes Following Pipeline Embolization Device Treatment of Complex Internal Carotid Artery Aneurysms: Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial
Abstract
BACKGROUND: Early and mid-term safety and efficacy of aneurysm treatment with the Pipeline Embolization Device (PED) has been well demonstrated in prior studies. OBJECTIVE: To present 5-yr follow-up for patients treated in the Pipeline for Uncoilable or Failed Aneurysms clinical trial. METHODS: In our prospective, multicenter trial, 109 complex internal carotid artery (ICA) aneurysms in 107 subjects were treated with the PED. Patients were followed per a standardized protocol at 180 d and 1, 3, and 5 yr. Aneurysm occlusion, in-stent stenosis, modified Rankin Scale scores, and complications were recorded. RESULTS: The primary endpoint of complete aneurysm occlusion at 180 d (73.6%) was previously reported. Aneurysm occlusion for those patients with angiographic follow-up progressively increased over time to 86.8% (79/91), 93.4% (71/76), and 95.2% (60/63) at 1, 3, and 5 yr, respectively. Six aneurysms (5.7%) were retreated. New serious device-related events at 1, 3, and 5 yr were noted in 1% (1/96), 3.5% (3/85), and 0% (0/81) of subjects. There were 4 (3.7%) reported deaths in our trial. Seventy-eight (96.3%) of 81 patients with 5-yr clinical follow-up had modified Rankin Scale scores ≤2. No delayed neurological deaths or hemorrhagic or ischemic cerebrovascular events were reported beyond 6 mo. No recanalization of a previously occluded aneurysm was observed. CONCLUSION: Our 5-yr findings demonstrate that PED is a safe and effective treatment for large and giant wide-necked aneurysms of the intracranial ICA, with high rates of complete occlusion and low rates of delayed adverse events.
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Cites
R: A Language and Environment for Statistical Computing
R Core Team (2025) · doi:10.32614/r.manuals · Cited by 352,181
Wiebers, D. O. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13860-3 · Cited by 3,905
The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort
The UCAS Japan Investigators (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113260 · Cited by 1,530
Pipeline for Uncoilable or Failed Aneurysms: Results from a Multicenter Clinical Trial
Becske, T., Kallmes, D. F., Saatci, I., McDougall, C. G., Szikora, I., Lanzino, G., Moran, C. J., Woo, H. H., Lopes, D. K., Berez, A. L., et al. (2013) · Radiology · doi:10.1148/radiol.13120099 · Cited by 1,108
Self-citationEndovascular Treatment of Intracranial Aneurysms With Flow Diverters: A Meta-Analysis
Brinjikji, W., Murad, M. H., Lanzino, G., Cloft, H. J., & Kallmes, D. F. (2013) · Stroke · doi:10.1161/strokeaha.112.678151 · Cited by 900
Self-citationThe Pipeline Embolization Device for the Intracranial Treatment of Aneurysms Trial
Nelson, P. K., Lylyk, P., Szikora, I., Wetzel, S. G., Wanke, I., & Fiorella, D. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2421 · Cited by 843
Self-citationKulcsár, Z., Houdart, E., Bonafé, A., Parker, G., Millar, J., Goddard, A. J. P., Renowden, S., Gál, G., Turowski, B., Mitchell, K., et al. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2370 · Cited by 521
Saatci, I., Yavuz, K., Ozer, C., Geyik, S., & Cekirge, H. S. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3246 · Cited by 368
Self-citationStent-Supported Aneurysm Coiling: A Literature Survey of Treatment and Follow-Up
Shapiro, M., Becske, T., Sahlein, D., Babb, J., & Nelson, P. K. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2719 · Cited by 244
Self-citationPipeline for uncoilable or failed aneurysms: 3-year follow-up results
Becske, T., Potts, M. B., Shapiro, M., Kallmes, D. F., Brinjikji, W., Saatci, I., McDougall, C. G., Szikora, I., Lanzino, G., Moran, C. J., et al. (2017) · Journal of Neurosurgery · doi:10.3171/2015.6.jns15311 · Cited by 229
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Cited by
Hanel, R. A., Kallmes, D. F., Lopes, D. K., Nelson, P. K., Siddiqui, A., Jabbour, P., Pereira, V. M., Szikora István, I., Zaidat, O. O., Bettegowda, C., et al. (2020) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2019-015091 · Cited by 313
Self-citationSarrami-Foroushani, A., Lassila, T., MacRaild, M., Asquith, J., Roes, K. C. B., Byrne, J. V., & Frangi, A. F. (2021) · Nature Communications · doi:10.1038/s41467-021-23998-w · Cited by 83
Metadata
- Authors
- Becske, T., Brinjikji, W., Potts, M. B., Kallmes, D. F., Shapiro, M., Moran, C. J., Levy, E. I., McDougall, C. G., Szikora, I., Lanzino, G., Woo, H. H., Lopes, D. K., Siddiqui, A. H., Albuquerque, F. C., Fiorella, D. J., Saatci, I., Cekirge, S. H., Berez, A. L., Cher, D. J., Berentei, Z., Marosfői, M., & Nelson, P. K.
- Venue
- Neurosurgery
- Published
- 2016-12-05
- Volume
- 80
- Issue
- 1
- Pages
- 40-48
- ISSN
- 0148-396X (ISSN-L)
- 1524-4040
- OpenAlex
- W2604204200
- Cited by
- 447
- References
- 16
- FWCI
- 28.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Long-Term Clinical and Angiographic Outcomes Following Pipeline Embolization Device Treatment of Complex Internal Carotid Artery Aneurysms: Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial. https://app.cochat.ai/papers/10.1093/neuros/nyw014
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- Becske, T., Brinjikji, W., Potts, M. B., Kallmes, D. F., Shapiro, M., Moran, C. J., Levy, E. I., McDougall, C. G., Szikora, I., Lanzino, G., Woo, H. H., Lopes, D. K., Siddiqui, A. H., Albuquerque, F. C., Fiorella, D. J., Saatci, I., Cekirge, S. H., Berez, A. L., Cher, D. J., . . . Nelson, P. K. (2017). Long-Term Clinical and Angiographic Outcomes Following Pipeline Embolization Device Treatment of Complex Internal Carotid Artery Aneurysms: Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial. Neurosurgery. https://doi.org/10.1093/neuros/nyw014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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