Cited by 93Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Risk FactorsHealth Promotion and Cardiovascular Prevention

INTERACTION BETWEEN CIGARETTE SMOMNG AND DIABETES MELLITUS IN THE PREDICTION OF DEATH ATTRIBUTED TO CARDIOVASCULAR DISEASE

SUAREZ, LUCINA, BARRETT-CONNOR, ELIZABETH·1984·American Journal of Epidemiology

Abstract

Previous studies have shown that the increased risk of cardiovascular disease in adults with diabetes is independent of heart disease risk factors and have suggested that the effect of these risk factors is similar in diabetics compared with nondiabetics. To determine whether there was interaction between diabetes and the classic heart disease risk factors (cholesterol, blood pressure, and cigarette smoking) in the prediction of cardiovascular death, the etiologic fraction due to interaction was assessed in a nine-year follow-up of 2,620 older Caucasian adults (60-79 years) who resided in Rancho Bernardo, California, 8.7% of whom had diabetes by history of fasting hyperglycemia. In these older adults, the frequency of categoric hypertension, hypercholesterolemia, or current cigarette smoking did not differ significantly among diabetics compared with nondiabetics. Overall, the age-adjusted relative cardiovascular mortality risk among diabetics was similar to that in nondiabetics for all risk factors except cigarette smoking, for which the relative risk for diabetics was 2.2 compared with 1.2 for nondiabetics. High cholesterol and systolic blood pressure levels showed no interaction with diabetes, but cigarette smoking had a large and significant interaction with diabetes, such that an estimated 65% of the cardiovascular disease deaths among diabetics could be attributed to the interaction of diabetes and cigarette smoking. If confirmed, these data have important implications for the prevention of cardiovascular death in older diabetics.

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Crossref · 10.1093/oxfordjournals.aje.a113933

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Authors
SUAREZ, L., & BARRETT-CONNOR, E.
Affiliations
University of California San Diego (US)
Corresponding author
BARRETT-CONNOR, ELIZABETH
Venue
American Journal of Epidemiology
Published
1984-11
Volume
120
Issue
5
Pages
670-675
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
OpenAlex
W2159061375
Cited by
92
References
12
Citations by year
2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Keywords
diabetes mellitus, cigarette smoking, cardiovascular mortality, cardiovascular disease, hypertension, hypercholesterolemia, systolic blood pressure, older adults, population attributable fraction, cardiovascular risk prediction
MeSH terms
Aged, Blood Pressure, California, Cardiovascular Diseases, Cholesterol, Death Certificates, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Risk, Sex Factors, Smoking, Diabetes Complications

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