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SERUM PLANT STEROLS AND CHOLESTEROL PRECURSORS REFLECT CHOLESTEROL ABSORPTION AND SYNTHESIS IN VOLUNTEERS OF A RANDOMLY SELECTED MALE POPULATION
Abstract
To investigate the regulation of serum levels of cholesterol precursor sterols and plant sterols, these noncholesterol sterols, fatty acids, and various parameters of cholesterol metabolism were analyzed in 63 volunteers from a randomly selected Finnish male population sample of 100 subjects, aged 50 years, who had normal dietary habits. Serum levels of cholesterol precursors, desmosterol and lathosterol (in terms of micrograms/mg cholesterol), were negatively related to both the fractional and absolute absorption of dietary cholesterol and serum high density lipoprotein (HDL) cholesterol, and positively related to overall cholesterol synthesis and serum very low density lipoprotein (VLDL) cholesterol. Serum levels of the plant sterols, campesterol and sitosterol, exhibited positive correlations with the polyunsaturated/saturated fatty acid ratio of dietary fat, the linoleic acid contents of plasma and dietary lipids, the amount of dietary plant sterols (as indicated by fecal output), fractional and absolute absorption of dietary cholesterol, and HDL cholesterol, but were inversely related to the overall cholesterol synthesis and VLDL cholesterol. Stepwise multiple regression analysis revealed that the serum level of campesterol was associated with fractional cholesterol absorption, dietary plant sterols, and biliary cholesterol secretion, and that of sitosterol with dietary plant sterols, cholesterol synthesis, fractional cholesterol absorption, and biliary cholesterol secretion. Thus, the serum non-cholesterol sterols are significant indicators of cholesterol absorption and synthesis even under basal conditions and, since gas liquid chromatographic determination of these sterols is quite simple, their measurement may be valuable for monitoring cholesterol metabolism in large-scale epidemiologic studies.
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“This pattern indicates that low cholesterol levels are not due to gastrointestinal loss or diet restrictions since these conditions will have increased levels of cholesterol precursors, especially lathosterol [87, 88].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [88]
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Tikkanen, M. J. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-27661-0_7 · Cited by 47
Weingärtner, O., Lütjohann, D., Vanmierlo, T., Müller, S., Günther, L., Herrmann, W., Böhm, M., Laufs, U., & Herrmann, M. (2011) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2011.03.008 · Cited by 46
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Ostlund, R. E., & Lin, X. (2006) · Current Atherosclerosis Reports · doi:10.1007/s11883-006-0024-x · Cited by 45
Effects of endurance exercise training on markers of cholesterol absorption and synthesis
Wilund, K., Feeney, L., Tomayko, E., Weiss, E., & Hagberg, J. M. (2009) · Physiological Research · doi:10.33549/physiolres.931515 · Cited by 45
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Robinson, J. G., & Davidson, M. H. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.4.461 · Cited by 44
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Mortaz, M. (2001) · Archives of Disease in Childhood · doi:10.1136/adc.84.3.212 · Cited by 44
Seo, H. S., & Choi, M. H. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.04.014 · Cited by 43
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Tammi, A., Rönnemaa, T., Rask-Nissilä, L., Miettinen, T. A., Gylling, H., Valsta, L. M., Viikari, J. S. A., Välimäki, I. A. T., & Simell, O. (2001) · Pediatric Research · doi:10.1203/00006450-200112000-00010 · Cited by 43
Self-citationGlueck, C. J., Kelley, W., Gupta, A. T., Fontaine, R. N., Wang, P., & Gartside, P. S. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90004-4 · Cited by 43
Kane, L., Moore, K. L., Lütjohann, D., Bikle, D. D., & Schwartz, J. B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1922 · Cited by 42
Gardès, C., Chaput, E., Staempfli, A. A., Blum, D., Richter, H. G., & Benson, G. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033423 · Cited by 42
Miettinend, T. A., Färkkilä, M. A., Vuoristo, M., Karvonen, A., Leino, R., Lehtola, J., Friman, C., Seppälä, K., & Tuominen, J. (1995) · Hepatology · doi:10.1002/hep.1840210508 · Cited by 42
Thongtang, N., Lin, J., Schaefer, E. J., Lowe, R. S., Tomassini, J. E., Shah, A. K., & Tershakovec, A. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.001 · Cited by 41
Bonde, Y., Eggertsen, G., & Rudling, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147772 · Cited by 41
Rajaratnam, R., Gylling, H., & Miettinen, T. A. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.097019 · Cited by 41
Self-citationFinkelstein, J. M., Heemels, M.-T., Shadan, S., & Weiss, U. K. (2014) · Nature · doi:10.1038/510047a · Cited by 41
Lupattelli, G., VUONO, S. D., & Mannarino, E. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.010 · Cited by 40
Myrie, S. B., Mymin, D., Triggs‐Raine, B. L., & Jones, P. J. H. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.028985 · Cited by 40
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Renner, O., Lütjohann, D., Richter, D., Strohmeyer, A., Schimmel, S., Müller, O. J., Stange, E. F., & Harsch, S. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-30 · Cited by 40
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Feio, C. M. A., Izar, M. C. D. O., Ihara, S. S. M., Kasmas, S. H., Martins, C. M., Feio, M. N. B., Maués, L. A. L., Borges, N. C. D. C., Moreno, R. A., Póvoa, R., et al. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11205 · Cited by 38
Dayspring, T. D., Varvel, S. A., Ghaedi, L., Thiselton, D. L., Bruton, J. L., & McConnell, J. P. (2015) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.08.003 · Cited by 38
Olkkonen, V. M., Gylling, H., & Ikonen, E. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.12.026 · Cited by 38
Gylling, H., KONTULA, K. K., Koivisto, U., Miettinen, H. E., & Miettinen, T. A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.38 · Cited by 38
Self-citationGylling, H., Färkkilä, M. A., Vuoristo, M., & Miettinen, T. A. (1995) · Hepatology · doi:10.1002/hep.1840210116 · Cited by 38
Self-citationLütjohann, D., Björkhem, I., & Ose, L. (1996) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519609088612 · Cited by 38
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Jakulj, L., Vissers, M. N., Groen, A. K., Hutten, B. A., Lütjohann, D., Veltri, E. P., & Kastelein, J. J. P. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001487 · Cited by 37
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Self-citationLaitinen, K., Isolauri, E., Kaipiainen, L., Gylling, H. K., & Miettinen, T. A. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508133608 · Cited by 35
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Relas, H., Gylling, H., & Miettinen, T. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31623-0 · Cited by 35
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Clarenbach, J. J., Reber, M., Lütjohann, D., von Bergmann, K., & Sudhop, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.p600009-jlr200 · Cited by 34
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Simonen, P. P., Gylling, H., & Miettinen, T. A. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00734-3 · Cited by 34
Self-citationNikkilä, K., Höckerstedt, K., & Miettinen, T. A. (1991) · Hepatology · doi:10.1002/hep.1840130409 · Cited by 34
Self-citationGylling, H., Strandberg, T. E., Tilvis, R. S., & Miettinen, T. A. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.694 · Cited by 34
Self-citationSemova, I., Levenson, A. E., Krawczyk, J., Bullock, K., Williams, K. A., Wadwa, R. P., Shah, A. S., Khoury, P. R., Kimball, T. R., Urbina, E. M., et al. (2019) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2019.09.008 · Cited by 33
Miettinen, T. E., Kiviluoto, T. A., Taavitsainen, M., Vuoristo, M., & Miettinen, T. A. (1998) · Hepatology · doi:10.1002/hep.510270302 · Cited by 33
Self-citationWang, H. H., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6082-8_8 · Cited by 33
García-Otín, A. L., Cofán, M., Junyent, M., Recalde, D., Cenarro, A., Pocovı́, M., Ros, E., & Civeira, F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2567 · Cited by 33
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Hirayama, T. T., Mizokami, Y., Honda, A., Homma, Y., Ikegami, T., Saito, Y., Miyazaki, T., & Matsuzaki, Y. (2009) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00450.x · Cited by 33
Ketomäki, A., Gylling, H., Siimes, M. A., Vuorio, A. F., & Miettinen, T. A. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000055771.28409.40 · Cited by 33
Self-citationKetomäki, A., Gylling, H., & Miettinen, T. A. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.10.008 · Cited by 33
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Role of naturally-occurring plant sterols on intestinal cholesterol absorption and plasmatic levels
Sanclemente, T., Marques-Lopes, I., Puzo, J., & García-Otín, A. L. (2009) · Journal of Physiology and Biochemistry · doi:10.1007/bf03165972 · Cited by 32
Bertolotti, M., Mussi, C., Pellegrini, E., Magni, A., Puppo, M. D., Ognibene, S., Carulli, L., Anzivino, C., Baldelli, E., Loria, P., et al. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s57714 · Cited by 32
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Simonen, P. P., Gylling, H. K., & Miettinen, T. A. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.07.030 · Cited by 32
Self-citationBATTA, A. K., Xu, G., Bollineni, J. S., Shefer, S., & Salen, G. (2004) · Metabolism · doi:10.1016/j.metabol.2004.08.004 · Cited by 32
Vanhanen, H. T. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00194968 · Cited by 32
Gremaud, G., Dalan, E., Piguet, C., Baumgartner, M., Ballabeni, P., Decarli, B., Leser, M. E., Berger, A., & Fay, L. B. (2002) · European Journal of Nutrition · doi:10.1007/s003940200008 · Cited by 32
van den Driessche, J. J., Plat, J., Konings, M. C. J. M., & Mensink, R. P. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02073-7 · Cited by 31
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Self-citation
Metadata
- Authors
- MIETTINEN, T. A., TILVIS, R. S., & KESÄNIEMI, Y. A.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- MIETTINEN, TATU A.
- ORCID
- KESÄNIEMI, Y. ANTERO
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01
- Volume
- 131
- Issue
- 1
- Pages
- 20-31
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2153014921
- Cited by
- 646
- References
- 0
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 16 · 2022: 10 · 2021: 18 · 2020: 9 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 17 · 2013: 33 · 2012: 23
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- phytosterols, cholesterol precursors, cholesterol absorption, cholesterol biosynthesis, campesterol, sitosterol, desmosterol, lathosterol, HDL cholesterol, VLDL cholesterol, biliary cholesterol secretion, linoleic acid, cholesterol metabolism, non-cholesterol sterols
- MeSH terms
- Absorption, Cholesterol, Cholesterol, Dietary, Desmosterol, Dietary Fats, Fatty Acids, Humans, Isomerism, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Phytosterols, Random Allocation, Sitosterols
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