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SERUM PLANT STEROLS AND CHOLESTEROL PRECURSORS REFLECT CHOLESTEROL ABSORPTION AND SYNTHESIS IN VOLUNTEERS OF A RANDOMLY SELECTED MALE POPULATION
Abstract
To investigate the regulation of serum levels of cholesterol precursor sterols and plant sterols, these noncholesterol sterols, fatty acids, and various parameters of cholesterol metabolism were analyzed in 63 volunteers from a randomly selected Finnish male population sample of 100 subjects, aged 50 years, who had normal dietary habits. Serum levels of cholesterol precursors, desmosterol and lathosterol (in terms of micrograms/mg cholesterol), were negatively related to both the fractional and absolute absorption of dietary cholesterol and serum high density lipoprotein (HDL) cholesterol, and positively related to overall cholesterol synthesis and serum very low density lipoprotein (VLDL) cholesterol. Serum levels of the plant sterols, campesterol and sitosterol, exhibited positive correlations with the polyunsaturated/saturated fatty acid ratio of dietary fat, the linoleic acid contents of plasma and dietary lipids, the amount of dietary plant sterols (as indicated by fecal output), fractional and absolute absorption of dietary cholesterol, and HDL cholesterol, but were inversely related to the overall cholesterol synthesis and VLDL cholesterol. Stepwise multiple regression analysis revealed that the serum level of campesterol was associated with fractional cholesterol absorption, dietary plant sterols, and biliary cholesterol secretion, and that of sitosterol with dietary plant sterols, cholesterol synthesis, fractional cholesterol absorption, and biliary cholesterol secretion. Thus, the serum non-cholesterol sterols are significant indicators of cholesterol absorption and synthesis even under basal conditions and, since gas liquid chromatographic determination of these sterols is quite simple, their measurement may be valuable for monitoring cholesterol metabolism in large-scale epidemiologic studies.
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“This pattern indicates that low cholesterol levels are not due to gastrointestinal loss or diet restrictions since these conditions will have increased levels of cholesterol precursors, especially lathosterol [87, 88].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [88]
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Metadata
- Authors
- MIETTINEN, T. A., TILVIS, R. S., & KESÄNIEMI, Y. A.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- MIETTINEN, TATU A.
- ORCID
- KESÄNIEMI, Y. ANTERO
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01
- Volume
- 131
- Issue
- 1
- Pages
- 20-31
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2153014921
- Cited by
- 646
- References
- 0
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 16 · 2022: 10 · 2021: 18 · 2020: 9 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 17 · 2013: 33 · 2012: 23
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- phytosterols, cholesterol precursors, cholesterol absorption, cholesterol biosynthesis, campesterol, sitosterol, desmosterol, lathosterol, HDL cholesterol, VLDL cholesterol, biliary cholesterol secretion, linoleic acid, cholesterol metabolism, non-cholesterol sterols
- MeSH terms
- Absorption, Cholesterol, Cholesterol, Dietary, Desmosterol, Dietary Fats, Fatty Acids, Humans, Isomerism, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Phytosterols, Random Allocation, Sitosterols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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