Cited by 646Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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SERUM PLANT STEROLS AND CHOLESTEROL PRECURSORS REFLECT CHOLESTEROL ABSORPTION AND SYNTHESIS IN VOLUNTEERS OF A RANDOMLY SELECTED MALE POPULATION

MIETTINEN, TATU A., TILVIS, REIJO S., KESÄNIEMI, Y. ANTERO·1990·American Journal of Epidemiology

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Abstract

To investigate the regulation of serum levels of cholesterol precursor sterols and plant sterols, these noncholesterol sterols, fatty acids, and various parameters of cholesterol metabolism were analyzed in 63 volunteers from a randomly selected Finnish male population sample of 100 subjects, aged 50 years, who had normal dietary habits. Serum levels of cholesterol precursors, desmosterol and lathosterol (in terms of micrograms/mg cholesterol), were negatively related to both the fractional and absolute absorption of dietary cholesterol and serum high density lipoprotein (HDL) cholesterol, and positively related to overall cholesterol synthesis and serum very low density lipoprotein (VLDL) cholesterol. Serum levels of the plant sterols, campesterol and sitosterol, exhibited positive correlations with the polyunsaturated/saturated fatty acid ratio of dietary fat, the linoleic acid contents of plasma and dietary lipids, the amount of dietary plant sterols (as indicated by fecal output), fractional and absolute absorption of dietary cholesterol, and HDL cholesterol, but were inversely related to the overall cholesterol synthesis and VLDL cholesterol. Stepwise multiple regression analysis revealed that the serum level of campesterol was associated with fractional cholesterol absorption, dietary plant sterols, and biliary cholesterol secretion, and that of sitosterol with dietary plant sterols, cholesterol synthesis, fractional cholesterol absorption, and biliary cholesterol secretion. Thus, the serum non-cholesterol sterols are significant indicators of cholesterol absorption and synthesis even under basal conditions and, since gas liquid chromatographic determination of these sterols is quite simple, their measurement may be valuable for monitoring cholesterol metabolism in large-scale epidemiologic studies.

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Crossref · 10.1093/oxfordjournals.aje.a115479

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Authors: MIETTINEN, T. A., TILVIS, R. S., & KESÄNIEMI, Y. A.
Affiliations: University of Helsinki (FI)
Corresponding author: MIETTINEN, TATU A.
ORCID: KESÄNIEMI, Y. ANTERO
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1990-01
Volume: 131
Issue: 1
Pages: 20-31
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a115479
OpenAlex: W2153014921
Cited by: 646
References: 0
Citations by year: 2026: 5 · 2025: 9 · 2024: 7 · 2023: 16 · 2022: 10 · 2021: 18 · 2020: 9 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 17 · 2013: 33 · 2012: 23
FWCI: 11.87
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: phytosterols, cholesterol precursors, cholesterol absorption, cholesterol biosynthesis, campesterol, sitosterol, desmosterol, lathosterol, HDL cholesterol, VLDL cholesterol, biliary cholesterol secretion, linoleic acid, cholesterol metabolism, non-cholesterol sterols
MeSH terms: Absorption, Cholesterol, Cholesterol, Dietary, Desmosterol, Dietary Fats, Fatty Acids, Humans, Isomerism, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Phytosterols, Random Allocation, Sitosterols

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SERUM PLANT STEROLS AND CHOLESTEROL PRECURSORS REFLECT CHOLESTEROL ABSORPTION AND SYNTHESIS IN VOLUNTEERS OF A RANDOMLY SELECTED MALE POPULATION

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