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Cited by 117Maternal and fetal healthcarePregnancy and preeclampsia studiesMaternal and Perinatal Health Interventions

Risk factors for abruptio placentae

Williams, Michelle A., Lieberman, Ellice, Mittendorf, Robert, Monson, Richard R., Schoenbaum, Stephen C.·1991·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a116181
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Abstract

The authors studied the relation of sociodemographic, medical, and life-style factors and abruptio placentae in a large cross-sectional data base. The 143 cases of abruption identified in the Delivery Interview Program, conducted in Boston from 1977 to 1980, were compared with 1,257 randomly selected controls. The authors used multiple logistic regression techniques to derive maximum likelihood estimates of the adjusted odds ratios and 95% confidence intervals as measures of the association between exposure factors and abruption. A history of chronic hypertension was associated with a threefold increase in risk (odds ratio (OR) = 3.1, 95% confidence interval (Cl) 1.1-8.4), but pregnancy-induced hypertension was not associated with abruption. Excess risk was associated with advanced maternal age (OR = 2.3, 95% Cl 1.3-3.9), low prepregnancy body mass index (OR = 2.3, 95% Cl 1.3-4.1), a history of prior stillbirth (OR = 3.5, 95% Cl 1.8-7.0), and at least weekly use of marijuana during pregnancy (OR = 2.8, 95% Cl 1.2-6.6). Overall, the association with cigarette smoking during pregnancy was of only borderline significance (OR = 1.5, 95% Cl 1.0-2.2), although there appeared to be a dose-response relation between the number of cigarettes smoked and risk of abruption.

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  • The risk of abruption is 3 to 4-fold higher among pregnant people with chronic hypertension.

    “The risk of abruption is 3 to 4-fold higher among pregnant people with chronic hypertension, and 4 to 6-fold higher among those with preeclampsia, particularly preeclampsia with severe features and superimposed preeclampsia (28–31).”

    From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [28]

  • The risk of abruption is 4 to 6-fold higher among those with preeclampsia, particularly preeclampsia with severe features and superimposed preeclampsia.

    “The risk of abruption is 3 to 4-fold higher among pregnant people with chronic hypertension, and 4 to 6-fold higher among those with preeclampsia, particularly preeclampsia with severe features and superimposed preeclampsia (28–31).”

    From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [28]

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Authors
Williams, M. A., Lieberman, E., Mittendorf, R., Monson, R. R., & Schoenbaum, S. C.
Affiliations
  • Harvard University (US)
  • Brigham and Women's Hospital (US)
  • Tufts University (US)
Corresponding author
Williams, Michelle A.
ORCID
Williams, Michelle A.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
1991-11-01
Volume
134
Issue
9
Pages
965-972
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a116181
OpenAlex
W1950815906
Cited by
117
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 3
FWCI
2.24
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (2P30 ES00002, P30ES000002, T32ES007069, 5T32 ES 07069)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords
placental abruption, risk factors, chronic hypertension in pregnancy, gestational hypertension, advanced maternal age, pre-pregnancy body mass index, marijuana use during pregnancy, cigarette smoking during pregnancy, dose-response relationship, sociodemographic factors, lifestyle factors
MeSH terms
Abruptio Placentae, Boston, Chronic Disease, Cross-Sectional Studies, Female, Fetal Death, Hospitals, Maternity, Humans, Hypertension, Infant, Newborn, Male, Marijuana Smoking, Maternal Age, Pregnancy, Pregnancy Outcome, Risk Factors, Smoking, Confounding Factors, Epidemiologic, Body Mass Index, Prevalence, Multivariate Analysis, Case-Control Studies, Delivery, Obstetric

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