Influence of maternal smoking on placental abruption in successive pregnancies: a population-based prospective cohort study in Sweden
Abstract
The authors examined associations between cumulative smoking during a woman's first and second pregnancies and risk of placental abruption in the second pregnancy. They performed a population-based prospective cohort study of 526,690 women who delivered their first two consecutive singletons in Sweden in 1983-2001. Using logistic regression models, the authors found that, among women without placental abruption in the first pregnancy, smoking was associated with increased risk of abruption in the second pregnancy; however, this effect was confined to exposure occurring during the second pregnancy (adjusted odds ratio (OR)=1.8, 95% confidence interval (CI): 1.4, 2.3) but not the first (adjusted OR=1.1, 95% CI: 0.9, 1.3). Among women with a prior abruption, the risk of repeating abruption was increased irrespective of smoking habits. When women smoked during both pregnancies, there was an almost 11-fold increase in risk (adjusted OR=10.9, 95% CI: 7.3, 16.3). These findings suggest that women who quit smoking before pregnancy may benefit from reduced risk of abruption. The observation that the recurrence of abruption is substantially increased regardless of changes in smoking habits suggests that factors other than smoking may influence the recurrence of placental abruption.
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Tobacco smoking is associated with a 1.7 to 2-fold increased risk of abruption, with a strong dose-response association between the number of cigarettes smoked per day.
“Tobacco smoking is associated with a 1.7 to 2-fold increased risk of abruption, with a strong dose-response association between the number of cigarettes smoked per day (39–41).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [40]
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Self-citation
- Authors
- Ananth, C. V., & Cnattingius, S.
- Affiliations
- University of Medicine and Dentistry of New Jersey (US)
- Karolinska Institutet (SE)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-29
- Volume
- 166
- Issue
- 3
- Pages
- 289-295
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2168009079
- Cited by
- 71
- References
- 39
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD038902, R01HD038902)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- placental abruption, maternal smoking, second pregnancy, cumulative smoking exposure, pregnancy outcomes
- MeSH terms
- Abruptio Placentae, Adult, Female, Humans, Mothers, Parity, Pregnancy, Prospective Studies, Recurrence, Risk Factors, Smoking, Sweden, Confounding Factors, Epidemiologic, Logistic Models, Odds Ratio, Smoking Cessation
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