Cited by 268Fatty Acid Research and HealthNutritional Studies and DietCardiovascular Health and Risk Factors

The DOI matches its Crossref record.

Fish consumption and cardiovascular disease in the physicians’ health study: A prospective study

Morris, Martha Clare, Manson, JoAnn E., Rosner, Bernard, Buring, Julie E., Willett, Walter C., Hennekens, Charles H.·1995·American Journal of Epidemiology

DOI 10.1093/oxfordjournals.aje.a117615

Open this paper in CoChat — free account

Abstract

The authors examined the association between dietary intake of fish and omega 3 fatty acids from seafood and the risk of cardiovascular disease in a prospective cohort study of 21,185 US male physicians who are participants in the Physicians' Health Study. In 4 years of follow-up, there were 281 incident cases of total (fatal and nonfatal) myocardial infarction, 173 cases of stroke, and 121 cardiovascular deaths. There was no evidence for association between dietary intake of fish and any cardiovascular endpoint, including myocardial infarction, stroke, and cardiovascular death. The relative risks of total myocardial infarction, adjusted for age and randomized treatment assignment, for categories of fish intake were: 1.0 for < 1 meal/week (referent), 1.6 (95% confidence interval (Cl) 1.1-2.3) for 1 fish meal/week; 1.4 (95% Cl 1.0-2.0) for 2-4 fish meals/week; and 1.2 (95% Cl 0.6-2.2) for > or = 5 fish meals/week; chi 2 for trend = 0.9, p = 0.34. The relative risks were similar for omega 3 fatty acid intake and for specific types of fish, and did not change after adjustment for history of hypertension, hypercholesterolemia, diabetes mellitus, or angina pectoris, parental history of myocardial infarction before age 60 years, obesity, exercise, smoking, alcohol use, saturated fat intake, and vitamin supplement use. These data do not support the hypothesis that moderate fish consumption lowers the risk of cardiovascular disease.

Integrity signals

Registry

Crossref · 10.1093/oxfordjournals.aje.a117615

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 268

Red Blood Cell Membrane Concentration of cis-Palmitoleic and cis-Vaccenic Acids and Risk of Coronary Heart Disease
Djoussé, L., Matthan, N. R., Lichtenstein, A. H., & Gaziano, J. M. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.027 · Cited by 69
Dietary Fish Oil (4 g Daily) and Cardiovascular Risk Markers in Healthy Men
Marckmann, P., Bladbjerg, E., & Jespersen, J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3384 · Cited by 70
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Lawrenson, J. G. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub3 · Cited by 71
Relations between the Consumption of Fatty or Lean Fish and Risk of Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis
Giosuè, A., Calabrese, I., Lupoli, R., Riccardi, G., Vaccaro, O., & Vitale, M. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac006 · Cited by 72
Impact of low v. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease
Musa-Veloso, K., Binns, M. A., Kocenas, A., Chung, C., Rice, H., Oppedal-Olsen, H., Lloyd, H., & Lemke, S. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511001644 · Cited by 60
“Of the studies, one was based on a cohort made up exclusively of women (the Nurses’ Health Study(18)); six publications were based on cohorts made up exclusively of men (the Health Professionals’ Follow-up Study(16,21), the Physicians’ Health Study(15,19), the Multiple Risk Factor Intervention Trial(17) and the Alpha-…”
BackgroundMethodInfluential
Fish Consumption and Acute Coronary Syndrome: A Meta-Analysis
Leung Yinko, S. S. L., Stark, K. D., Thanassoulis, G., & Pilote, L. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.04.016 · Cited by 59
“Gramenzi, 1990 (Italy)(27) 1983-1989 936 women 49 (21-69) 287 (total MI) Questionnaire-based interview <1/wk, 1/wk, >1/wk Age, area of residence, education, smoking, hyperlipidemia, diabetes, hypertension, BMI, intake of carrots, green vegetables, fresh fruit, meat, ham and salami, butter, total fat score, coffee cons…”
Marine n-3 Polyunsaturated Fatty Acids in Adipose Tissue and the Risk of Acute Coronary Syndrome
Joensen, A. M., Overvad, K., Dethlefsen, C., Johnsen, S. P., Tjønneland, A. M., Rasmussen, L. H., & Schmidt, E. B. (2011) · Circulation · doi:10.1161/circulationaha.110.987057 · Cited by 58
The Utility of Omega-3 Fatty Acids in Cardiovascular Disease
Saremi, A., & Arora, R. R. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3180a5f0bb · Cited by 57
“In contrast to both of the previously mentioned studies, the Chicago Western Electric Study and the Physicians’ Health Study did not find a significant association between fish consumption and stroke.(20,21) Much of the data on the association between fish consumption and stroke have been on total stroke incidence (is…”
Result
Dietary phylloquinone intake as a potential marker for a heart-healthy dietary pattern in the Framingham Offspring cohort
Braam, L. A. J. L. M., McKeown, N. M., Jacques, P. F., Lichtenstein, A. H., Vermeer, C., Wilson, P. W. F., & Booth, S. L. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.06.021 · Cited by 57
Habitual fish consumption and risk of incident stroke: the European Prospective Investigation into Cancer (EPIC)–Norfolk prospective population study
Myint, P., Welch, A., Bingham, S., Luben, R., Wareham, N., Day, N., & Khaw, K. (2006) · Public Health Nutrition · doi:10.1017/phn2006942 · Cited by 57
Low level of n-3 polyunsaturated fatty acids in erythrocytes is a risk factor for both acute ischemic and hemorrhagic stroke in Koreans
Park, Y., Park, S., Yi, H.-J., Kim, H. Y., Kang, S., Kim, J., & Ahn, H. Y. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.10.018 · Cited by 54
“Previous prospective studies reported a significant inverse association between fish intake and risk of total stroke, particularly ischemic stroke [22-24].”
Background
The Relationship between Fish Intake and Urinary Trimethylamine‐ N ‐Oxide
Yin, X., Gibbons, H., Rundle, M., Frost, G. S., McNulty, B. A., Nugent, A. P., Walton, J., Flynn, A., & Brennan, L. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900799 · Cited by 54
Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to the safety assessment of wild and farmed fish
(EFSA), E. F. S. A. (2005) · EFSA Journal · doi:10.2903/j.efsa.2005.236 · Cited by 55
Acute Coronary Syndrome Patients With Depression Have Low Blood Cell Membrane Omega-3 Fatty Acid Levels
Amin, A. A., Menon, R. A., Reid, K. J., Harris, W. S., & Spertus, J. A. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318188a01e · Cited by 52
Evidence-based guidelines for cardiovascular disease prevention in women
Mosca, L. D. P. C., Appel, L. J., & Benjamin, E. J. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.04.052 · Cited by 50
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Henshaw, K. S. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub2 · Cited by 53
Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: a meta-analysis of randomized controlled trials
Yang, Y., Lu, N., Chen, D., Meng, L., Zheng, Y., & Hui, R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.025924 · Cited by 50
“A growing body of evidence has related the antiatherogenic and antithrombotic effects of n–3 PUFAs to the suppression of plasma soluble adhesion molecules, including sVCAM-1, sICAM-1, sE-selectin, and sP-selectin (9, 10).”
Background
Altered erythrocyte n-3 fatty acids in Mediterranean patients with coronary artery disease
Paganelli, F. F., Maixent, J. M., Duran, M., Parhizgar, R. R., Piéroni, G., & Sennoune, S. R. (2001) · International Journal of Cardiology · doi:10.1016/s0167-5273(00)00442-3 · Cited by 48
Omega-3 Fatty Acids and Cognitive Function in Women
Robinson, J. G., Ijioma, N., & Harris, W. S. (2010) · Women s Health · doi:10.2217/whe.09.75 · Cited by 50
“Morris MC, Manson JE, Rosner B, et al. Fish consumption and cardiovascular disease in the Physicians’ Health Study: a prospective study.”
Result
Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction
Park, Y., Lim, J., Lee, J., & Kim, S.-G. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509990298 · Cited by 47
Primary stroke prevention
de Freitas, G. R., & Bogousslavsky, J. (2001) · European Journal of Neurology · doi:10.1046/j.1468-1331.2001.00150.x · Cited by 46
Fish Consumption and Sudden Cardiac Death
Kromhout, D. (1998) · JAMA · doi:10.1001/jama.279.1.65 · Cited by 55
Primary and Secondary Prevention of Ischemic Stroke
Paciaroni, M., & Bogousslavsky, J. (2010) · European Neurology · doi:10.1159/000285183 · Cited by 44
Continuous decline in mortality from coronary heart disease in Japan despite a continuous and marked rise in total cholesterol: Japanese experience after the Seven Countries Study
Sekikawa, A., Miyamoto, Y., Miura, K., Nishimura, K., Willcox, B. J., Masaki, K. H., Rodriguez, B., Tracy, R. P., Okamura, T., & Kuller, L. H. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv143 · Cited by 44
Omega-3 polyunsaturated fatty acids focusing on eicosapentaenoic acid and docosahexaenoic acid in the prevention of cardiovascular diseases: a review of the state-of-the-art
Watanabe, Y., & Tatsuno, I. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2021.1863784 · Cited by 43
Fish and cardiovascular health
Undeland, I., Ellegård, L., & Sandberg, A. (2004) · Scandinavian Journal of Nutrition · doi:10.1080/11026480410000427 · Cited by 43
Fish consumption and the incidence of cerebrovascular disease
Montonen, J., Järvinen, R., Reunanen, A., & Knekt, P. (2009) · British Journal of Nutrition · doi:10.1017/s0007114509274782 · Cited by 40
Fish consumption and risk of stroke in Swedish women.
Larsson, S., Virtamo, J., & Wolk, A. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002287 · Cited by 50
Dietary fats and coronary heart disease
Temple, N. J. (1996) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(96)84823-2 · Cited by 40
Varying incorporation of fatty acids into phospholipids from muscle, adipose and pancreatic exocrine tissues and thymocytes in adult rats fed with diets rich in different fatty acids
Soriguer, F., Tinahones, F. J., Monzón, A., Pareja, A., Rojo‐Martínez, G., Moreno, F., Esteva, I., & Gómez‐Zumaquero, J. M. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007684808188 · Cited by 39
“Values of myristic acid (14:0) were very similar in all the diet groups, even in the tissues of those animals fed with polyunsaturated fatty acids, an observation which might explain some of the paradoxical adverse effects of diets enriched with these two fatty acids [3, 25-27].”
Omega–3 Fatty Acids, Inflammation and Angiogenesis: Nutrigenomic Effects as an Explanation for Anti-Atherogenic and Anti-Inflammatory Effects of Fish and Fish Oils
Massaro, M., Scoditti, E., Carluccio, M. A., Montinari, M. R., & Caterina, R. D. (2007) · Lifestyle Genomics · doi:10.1159/000109871 · Cited by 42
BMI Affects the Relationship between Long Chain N-3 Polyunsaturated Fatty Acid Intake and Stroke Risk: a Meta-Analysis
Cheng, P., Huang, W. C., Bai, S., Wu, Y., Jia, Y., Zhu, X., Qi, Z., Shao, W., & Xie, P. (2015) · Scientific Reports · doi:10.1038/srep14161 · Cited by 40
Relationship between Coronary Artery Disease and Non-HDL-C, and Effect of Highly Purified EPA on the Risk of Coronary Artery Disease in Hypercholesterolemic Patients Treated with Statins: Sub-Analysis of the Japan EPA Lipid Intervention Study (JELIS)
Sasaki, J., Yokoyama, M., Matsuzaki, M., Saito, Y., Origasa, H., Ishikawa, Y., Oikawa, S., Itakura, H., Hishida, H., Kita, T., et al. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.8326 · Cited by 35
Do Fat Supplements Increase Physical Performance?
Macaluso, F., Barone, R., Catanese, P., Carini, F., Rizzuto, L., Farina, F., & Felice, V. D. (2013) · Nutrients · doi:10.3390/nu5020509 · Cited by 39
“Food integration with DHA and EPA seems to reduce the incidence of cardiovascular diseases [4,5], reduce the release of inflammatory acute-phase proteins [6,7], and reduce superoxide anion production from stimulated blood neutrophils [8], although an old epidemiologic study stated that fish oil did not lower the risk…”
Background
Omega‐3 and Omega‐6 Fatty Acids in the Insulin Resistance Syndrome
Rustan, A. C., Nenseter, M. S., & Drevon, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51844.x · Cited by 34
Sudden Cardiac Death and the Role of Medical Therapy
Arshad, A., Mandava, A., Kamath, G. S., & Musat, D. L. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.12.003 · Cited by 32
Omega‐3 polyunsaturated acids and cardiovascular disease: notable ethnic differences or unfulfilled promise?
PATEL, J. V., TRACEY, I., HUGHES, E. A., & LIP, G. Y. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03956.x · Cited by 32
Gender-Specific Associations of Marine n-3 Fatty Acids and Fish Consumption with 10-Year Incidence of Stroke
de Goede, J., Verschuren, W. M. M., Boer, J. M. A., Kromhout, D., & Geleijnse, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033866 · Cited by 33
“In four [8,9,12,13] out of six [8,9,12,13,17,20] prospective studies carried out in women from western countries, fish consumption was inversely associated with stroke, whereas only two [7,10] out of seven [7,8,10,12,14,15,20] studies reported inverse associations in men.”
BackgroundResultInfluential
Fish Consumption and Stroke: A Community Case-Control Study in Asturias, Spain
Caicoya, M. (2002) · Neuroepidemiology · doi:10.1159/000054807 · Cited by 31
Fish and N-3 fatty acids for the prevention and treatment of coronary heart disease: nutrition is not pharmacology
de Lorgeril, M., & Salen, P. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01020-3 · Cited by 31
Omega-3 Fatty Acids and Primary and Secondary Prevention of Cardiovascular Disease
Cao, Y., Lü, L., Liang, J., Liu, M., Li, X., Sun, R., Zheng, Y., & Zhang, P. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0407-5 · Cited by 32
Physicians' Health Study
Skerrett, P. J., & Hennekens, C. H. (2005) · Wiley eBooks · doi:10.1002/0470011815.b2a01045 · Cited by 30
Self-citation
Omega-3 Fatty Acids: A Growing Ocean of Choices
Fares, H., Lavie, C. J., DiNicolantonio, J. J., O’Keefe, J. H., & Milani, R. V. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0389-6 · Cited by 31
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
Ueno, Y., Miyamoto, N., Yamashiro, K., Tanaka, R., & Hattori, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225549 · Cited by 30
“They classified subjects into consuming <1, 1, 2–4, and ≥5 fish meals/week, but a higher frequency of fish consumption was not shown to lower the incidence of fatal and non-fatal stroke [25].”
Background
Nutrient profile of Indian climbing perch, Anabas testudineus
Paul, B., Chanda, S., Bhowmick, S., Sridhar, N., Saha, G. S., & Giri, S. (2017) · SAARC Journal of Agriculture · doi:10.3329/sja.v15i1.33156 · Cited by 26
“Data are represented as Mean ± S.E. (n=8) sources, namely, biosynthesis and diet (Hearn et al., 1987, Morris et al., 1995, Kamler et al., 2001).”
Method
Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan
Shibutami, E., Ishii, R., Harada, S., Kurihara, A., Kuwabara, K., Kato, S., Iida, M., Akiyama, M. O., Sugiyama, D., Hirayama, A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246456 · Cited by 26
“As the typical inverse relationship between fish intake and CVD risk [57, 58] contradicts the utility of TMAO concentrations as a high-risk marker, the above risk supposition might need to be modified for populations with high fish intake.”
Background
Sub-optimal taurine status may promote platelet hyperaggregability in vegetarians
McCarty, M. F. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2002.11.007 · Cited by 26
Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects
Paulo, M. C., Andrade, A. M., Andrade, M. L., Morais, M. G., Kiely, M. E., Parra, D., Martínez, J. A., Þórsdóttir, I., & Bandarra, N. M. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.11.007 · Cited by 26
DIET, LIPOPROTEINS, AND CORONARY HEART DISEASE
Schaefer, E. J., & Brousseau, M. E. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70035-9 · Cited by 26
Therapeutic lifestyle change and adult treatment panel III: Evidence then and now
Stone, N. J., & Horn, L. V. (2002) · Current Atherosclerosis Reports · doi:10.1007/s11883-002-0047-x · Cited by 26
Consumption of Fruit and Wine and the Decline in Cerebrovascular Disease Mortality in Spain (1975–1993)
Rodríguez‐Artalejo, F., Guallar‐Castillón, P., Banegas, J. R., Manzano, B. D. A., & Calero, J. D. R. (1998) · Stroke · doi:10.1161/01.str.29.8.1556 · Cited by 25
Fish Consumption and Risk of Sudden Cardiac Death
Sheard, N. F. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1998.tb06133.x · Cited by 27
The role of omega-3-fatty acids in the prevention of cardiac events
Banning, M. (2005) · British Journal of Nursing · doi:10.12968/bjon.2005.14.9.18075 · Cited by 23
The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies
Ismail, N. A., Posma, J. M., Frost, G. S., Holmes, E. C., & García‐Pérez, I. (2013) · Electrophoresis · doi:10.1002/elps.201300066 · Cited by 23
Review: The role of omega-3 fatty acids in cardiovascular disease, hypertriglyceridaemia and diabetes mellitus
Kandasamy, N., Joseph, F., & Goenka, N. (2008) · The British Journal of Diabetes · doi:10.1177/14746514080080030301 · Cited by 22
Marine-derived n-3 fatty acids therapy for stroke
Campano, C. G. A., MacLeod, M. J., Thiès, F., Aucott, L. S., & Macleod, M. R. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012815 · Cited by 22
Systemic Inflammation, Endothelial Dysfunction, Dietary Fatty Acids and Micronutrients as Risk Factors for Stroke: A Selective Review
Feigin, V. L., Anderson, C. S., & Mhurchú, C. N. (2002) · Cerebrovascular Diseases · doi:10.1159/000057846 · Cited by 21
Dietary fats and other nutrients on stroke
Larsson, S. C. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283592eea · Cited by 18
“was no significant association between long-chain omega-3 PUFA intake and stroke risk in cohorts of US health professionals [12,16], US male physicians [22], or Swedish [13], Finnish [23], or Chinese [24] men and women.”
Background
Beneficial effects of omega-3 fatty acids: the current evidence.
Gazi, I. F., Liberopoulos, E. N., Saougos, V. G., & Elisaf, M. (2006) · PubMed · Cited by 19
The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease
Aarsetoey, H., Grundt, H., Nygaard, O. K., & Nilsen, D. W. T. (2012) · Cardiology Research and Practice · doi:10.1155/2012/303456 · Cited by 18
Fish Protein Stimulated the Fibrinolysis in Rats
Murata, M., Sano, Y., Bannai, S., et al. (2004) · Annals of Nutrition and Metabolism · doi:10.1159/000081971 · Cited by 18
Nutrition and prevention of ischemic stroke: present knowledge, limitations and future perspectives
Strazzullo, P., Scalfi, L., Branca, F., Cairella, G., Garbagnati, F., Siani, A., Barba, G., Rubba, P., & Mancia, G. (2004) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/s0939-4753(04)80017-6 · Cited by 17
Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells
Tanaka, S., Ishihara, N., Suzuki, S., Watanabe, Y., Nagayama, D., Yamaguchi, T., Ohira, M., Saiki, A., Tanaka, T., & Tatsuno, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-46461-9 · Cited by 17
Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells
Ishihara, N., Suzuki, S., Tanaka, S., Watanabe, Y., Nagayama, D., Saiki, A., Tanaka, T., & Tatsuno, I. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7141 · Cited by 16
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Henshaw, K. S. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253 · Cited by 16
Oily fish and fish oil supplements in the prevention of coronary heart disease
Minnis, R. C., Haq, I. U., Jackson, P., Yeo, W. W., & Ramsay, L. E. (1998) · Journal of Human Nutrition and Dietetics · doi:10.1046/j.1365-277x.1998.00074.x · Cited by 15
Use and misuse of dietary fatty acids for the prevention and treatment of coronary heart disease
de Lorgeril, M., & Salen, P. (2004) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2004032 · Cited by 15
Radical-Scavenging Activities of Fish and Fishery Products.
Khanum, M. N., Yamaguchi, T., HIROISHI, S., MURAOKA, F., Takamura, H., & Matoba, T. (1999) · Food Science and Technology Research · doi:10.3136/fstr.5.193 · Cited by 15
In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products
Christodoulou, P., Vlassopoulou, M., Zervoú, M., Xanthakos, E., Moulos, P., Koutrotsios, G., Zervakis, G. I., Kerezoudi, E. N., Mitsou, E. K., Saxami, G., et al. (2023) · Journal of Fungi · doi:10.3390/jof9010128 · Cited by 16
“In addition, fish, which is an important source of trimethylamine in the diet [79], is not associated with risk of cardiovascular disease in the “Physicians’ Health Study” [80].”
Background
New approaches to therapy with omega-3 fatty acids
Kakar, P., Watson, T., & Lip, G. Y. H. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-008-0012-4 · Cited by 13
Role of Wild Game in the Diet of Recreationists in South Carolina
Burger, J., & Gochfeld, M. (2002) · Journal of Environmental Planning and Management · doi:10.1080/09640560120100213 · Cited by 13
Correction: Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan
Shibutami, E., Ishii, R., Harada, S., Kurihara, A., Kuwabara, K., Kato, S., Iida, M., Akiyama, M. O., Sugiyama, D., Hirayama, A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250864 · Cited by 13
Canadians’ Dietary Intake from 2007 to 2011 and across Different Sociodemographic/Lifestyle Factors Using the Canadian Health Measures Survey Cycles 1 and 2
Hosseini, Z., Whiting, S. J., & Vatanparast, H. (2019) · Journal of Nutrition and Metabolism · doi:10.1155/2019/2831969 · Cited by 15
Gut Microbiota Composition and Metabolites as the new Determinants of Cardiovascular Pathology Development
Drapkina, O. M., & Kaburova, A. N. (2020) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2020-04-02 · Cited by 12
“Кроме того, потребление рыбы, которая является одном из ключевых источников ТМА, не показало связи с риском развития ССЗ в исследовании здоровья врачей (Physicians’ health study) [50].”
Diet and Neuroimaging Markers of Cerebrovascular Disease
Gu, Y., & Scarmeas, N. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0044-4 · Cited by 11
The Role of Diet in the Prevention and Treatment of Cardiovascular Disease
Richter, C. K., Skulas‐Ray, A. C., & Kris‐Etherton, P. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00027-8 · Cited by 13
Dietary Fish or Seafood Consumption Is Not Related to Cerebrovascular Disease Risk in Twin Veterans
Bravata, D. M., Wells, C. K., Brass, L. M., Morgan, T. M., Lichtman, J. H., & Concato, J. (2007) · Neuroepidemiology · doi:10.1159/000107277 · Cited by 11
Poisson, acides gras oméga 3 et risque cardiovasculaire : données épidémiologiques
Lecerf, J. (2004) · Cahiers de Nutrition et de Diététique · doi:10.1016/s0007-9960(04)94447-1 · Cited by 13
Effects of dietary fat intake in sudden death: Reduction of death with omega-3 fatty acids
Lee, K. W., Hamaad, A., MacFadyen, R. J., & Lip, G. Y. H. (2004) · Current Cardiology Reports · doi:10.1007/s11886-004-0040-9 · Cited by 11
Fish consumption benefits and PFAS risks: Epidemiology and public health recommendations
Hamade, A. K. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101736 · Cited by 12
Absence of cardiovascular benefits and sportfish consumption among St. Lawrence River anglers
Godin, C., Shatenstein, B., Paradis, G., & Kosatsky, T. (2003) · Environmental Research · doi:10.1016/j.envres.2003.07.006 · Cited by 10
Is there a different dietetic pattern depending on self-knowledge of high blood pressure?
Tormo, M. J., Navarro, C., Chirlaque, M. D., et al. (2000) · European Journal of Epidemiology · doi:10.1023/a:1011056404243 · Cited by 10
Hiperlipidemias e fatores dietéticos: estudo transversal entre nipo-brasileiros
Bevilacqua, M. R., Gimeno, S. G. A., Matsumura, L. K., & Ferreira, S. R. G. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000400008 · Cited by 10
Supplemental and Complementary Alternatives to Hormone Replacement Therapy
Keller, C. S., Keller, C. S., & Keller, C. (1999) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.1999.tb00562.x · Cited by 10
Does self-reported history of hypertension predict cardiovascular death? Comparison with blood pressure measurement in a 19-year prospective study
Higashiyama, A., Murakami, Y., Hozawa, A., Okamura, T., Hayakawa, T., Kadowaki, T., Kita, Y., Okayama, A., & Ueshima, H. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3280586735 · Cited by 9
Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats
Vikøren, L. A. S., Drotningsvik, A., Bergseth, M. T., Mjøs, S. A., Mola, N., Leh, S. M., Mellgren, G., & Gudbrandsen, O. A. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1333395 · Cited by 9
“Yet, reports on associations of fish consumption and reduced cardiovascular disease (CVD) risk are inconsistent [3,4].”
Background
Enfermedad cardiovascular y grasas: “amigo o villano”
Rubio, M. Á. (2002) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(02)74448-3 · Cited by 9
Novel therapies for the prevention of stroke
Boos, C. J., & Lip, G. Y. H. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.12.1615 · Cited by 9
“The Physicians Health study showed a possible but not statistically significant relationship between fish intake and total stroke [183].”
Background
Potential Benefits of Preventive Nutrition Strategies
Willett, W. C. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-880-9_28 · Cited by 8
Self-citation
ω-3 polyunsaturated fatty acids and the cardiovascular system
Крыжановский, С. А., & Вититнова, М. Б. (2009) · Human Physiology · doi:10.1134/s036211970904015x · Cited by 10
Marine-derived n-3 fatty acids therapy for stroke
Campano, C. G. A., MacLeod, M. J., Aucott, L. S., & Thiès, F. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012815.pub2 · Cited by 9
Dietary Fats and Blood Pressure
Mori, T. A., Burke, V., & Beilin, L. J. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-03961-1.50010-6 · Cited by 13
Omega-3 polyunsaturated fatty acids and cardiovascular disease: an emphasis on omega-3-acid ethyl esters 90 for the treatment of hypertriglyceridemia
Tatsuno, I. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.971756 · Cited by 7
“On the other hand, several observational studies [4,6,7,9,10] demonstrate benefits with fish oil in the prevention of non-fatal MI and acute coronary syndrome, while subsequent large-scale randomized studies demonstrated mixed outcomes, with some demonstrating benefits with fish oil, first and foremost, against CV dea…”
Background
Nutritional Supplements Modulating Metabolic Syndrome Risk Factors and the Prevention of Cardiovascular Disease
Juturu, V., & Gormley, J. J. (2005) · Current Nutrition & Food Science · doi:10.2174/1573401052953249 · Cited by 7
“[69,70] reported that omega-3 fatty acids from fish oil reduced blood pressure (-3.”
Background
Effects of Omega‐3 Fatty Acids on Cardiovascular Disease: Summary
Wang, C., Chung, M. K., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., DeVine, D., Lawrence, A., & Lau, J. T. F. (2004) · Cited by 7
Health Aspects of Fish and n-3 Polyunsaturated Fatty Acids from Plant and Marine Origin
de Deckere, E. A. M. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-226-5_13 · Cited by 7
Integrating Food Policy with Growing Health and Wellness Concerns: An Analytical Literature Review of the Issues Affecting Government, Industry, and Civil SocietyPreprint
Cash, S. B., Cortus, B., Goddard, E. W., Han, A., Lerohl, M. L., & Lomeli, J. L. (2005) · RePEc: Research Papers in Economics · doi:10.7939/r3js9h72g · Cited by 8
“In contrast to these findings that noted protective effects, both the Chicago Western Electric Study (Orencia, 1996) and the Physicians’ Health Study (Morris et al., 1995) failed to find any association between reported fish intake and stroke incidence.”
Result
Fish consumption, n-3 fatty acids, and coronary heart disease
Kromhout, D. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198525738.003.0018 · Cited by 7
Fish, n-3 Polyunsaturated Fatty Acids, and Cardiovascular Disease
McEvoy, C. T., Young, I. S., & Woodside, J. V. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-894-8_10 · Cited by 7
Marine-derived n-3 fatty acids therapy for stroke
Campano, C. G. A., MacLeod, M. J., Aucott, L. S., & Thiès, F. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012815.pub3 · Cited by 6

Authors: Morris, M. C., Manson, J. E., Rosner, B., Buring, J. E., Willett, W. C., & Hennekens, C. H.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: Morris, Martha Clare
ORCID: Morris, Martha Clare
Manson, JoAnn E.
Rosner, Bernard
Buring, Julie E.
Willett, Walter C.
Hennekens, Charles H.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1995-07-15
Volume: 142
Issue: 2
Pages: 166-175
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a117615
OpenAlex: W2271684178
Cited by: 268
References: 0
Citations by year: 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 8 · 2016: 3 · 2015: 3 · 2014: 12 · 2013: 5 · 2012: 21
FWCI: 7.97
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-34595, HL 26490, R01HL034595)
National Cancer Institute (CA 34944)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords: fish consumption, omega-3 fatty acids, seafood, cardiovascular disease, myocardial infarction, stroke, cardiovascular mortality, dietary intake, male physicians, cardiovascular risk
MeSH terms: Aged, Cardiovascular Diseases, Cerebrovascular Disorders, Diet, Follow-Up Studies, Health Surveys, Humans, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk Factors, Fatty Acids, Omega-3, Multivariate Analysis, Proportional Hazards Models, Seafood

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fish consumption and cardiovascular disease in the physicians’ health study: A prospective study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks