Cited by 39Fatty Acid Research and HealthNutritional Studies and DietAquaculture Nutrition and Growth

Omega‐3 polyunsaturated acids and cardiovascular disease: notable ethnic differences or unfulfilled promise?

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PATEL, J.V., TRACEY, I., HUGHES, E.A., LIP, G.Y.·2010·Journal of Thrombosis and Haemostasis

Abstract

The consumption of long chain omega-3 polyunsaturated acids (PUFA) is considered to protect against cardiovascular disease and promote longevity following a heart attack. Historically, research in this area was fuelled by compelling reports of the cardiovascular benefits of omega-3 PUFA in select populations and cultures. More recent studies, in wider populations, suggest discordant findings: differences that are difficult to reconcile as the mechanism of action of omega-3 PUFA are poorly understood. As such, the use of this 'natural treatment' for cardiovascular disease is increasingly controversial, and potentially one of unfulfilled promise. To what extent does ethnicity influence the impact that omega-3 PUFA have on cardiovascular disease and its associated complications? We were interested to review the benefits of omega-3 PUFA in the management of cardiovascular risk amongst diverse ethnic groups. Using a systematic review of literature relating to omega-3 PUFA and cardiovascular disease, we found ethnicity to be a factor that accounts for inconsistency between studies. Some of the effects of omega-3 PUFA are limited to cultures with a very high omega-3 intake, and in turn, ethnicity moderates the efficiency with which PUFA are derived from the diet. Moreover, omega-3 PUFA are an important health care intervention in the current climate of globalization, where supplementation is likely to give protection to cultural groups undergoing dietary transition. Future epidemiological research into the efficacy of omega-3 PUFA in cardiovascular disease should consider the influence of ethnicity.

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Crossref · 10.1111/j.1538-7836.2010.03956.x

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Authors
PATEL, J. V., TRACEY, I., HUGHES, E. A., & LIP, G. Y.
Affiliations
Birmingham City Hospital (GB)
Corresponding author
LIP, G.Y.
Venue
Journal of Thrombosis and Haemostasis
Publisher
Elsevier BV
Published
2010-10
Volume
8
Issue
10
Pages
2095-2104
ISSN
1538-7836 (ISSN-L)
OpenAlex
W1512707865
Cited by
32
References
110
Citations by year
2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 3 · 2015: 1 · 2013: 3 · 2012: 1
FWCI
0.32
Type
journal article
Language
en
Open access
Locations
  • Journal of Thrombosis and Haemostasis (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords
omega-3 polyunsaturated fatty acids, cardiovascular disease, ethnicity, ethnic differences, dietary supplementation, nutrition transition, cardiovascular risk, Mediterranean diet
MeSH terms
Cardiovascular Diseases, Cross-Sectional Studies, Cultural Characteristics, Fatty Acids, Unsaturated, Glucose, Humans, Hypertension, Obesity, Research Design, Risk, Risk Factors, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Treatment Outcome

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