Omega‐3 polyunsaturated acids and cardiovascular disease: notable ethnic differences or unfulfilled promise?
Open accessAbstract
The consumption of long chain omega-3 polyunsaturated acids (PUFA) is considered to protect against cardiovascular disease and promote longevity following a heart attack. Historically, research in this area was fuelled by compelling reports of the cardiovascular benefits of omega-3 PUFA in select populations and cultures. More recent studies, in wider populations, suggest discordant findings: differences that are difficult to reconcile as the mechanism of action of omega-3 PUFA are poorly understood. As such, the use of this 'natural treatment' for cardiovascular disease is increasingly controversial, and potentially one of unfulfilled promise. To what extent does ethnicity influence the impact that omega-3 PUFA have on cardiovascular disease and its associated complications? We were interested to review the benefits of omega-3 PUFA in the management of cardiovascular risk amongst diverse ethnic groups. Using a systematic review of literature relating to omega-3 PUFA and cardiovascular disease, we found ethnicity to be a factor that accounts for inconsistency between studies. Some of the effects of omega-3 PUFA are limited to cultures with a very high omega-3 intake, and in turn, ethnicity moderates the efficiency with which PUFA are derived from the diet. Moreover, omega-3 PUFA are an important health care intervention in the current climate of globalization, where supplementation is likely to give protection to cultural groups undergoing dietary transition. Future epidemiological research into the efficacy of omega-3 PUFA in cardiovascular disease should consider the influence of ethnicity.
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Investigators have described ethnicity as a possible source of inconsistent findings in studies of omega-3 fatty acid intake and cardiovascular outcomes.
“Ethnicity has been described as a factor that may contribute to inconsistencies in results from studies of the effects of OM3 fatty acid consumption on cardiovascular disease outcomes.60”
From Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: The EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial (2014) · cites this paper as [60]
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Omega-3 Fatty Acids: The “Japanese” Factor?
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Patel, J. V., CASLAKE, M. J., Vyas, A., Cruickshank, J. K., Prabhakaran, D., Bhatnagar, D., Reddy, K. S., Lip, G. Y. H., Mackness, M., Hughes, E. A., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.10.010 · Cited by 20 · see citing works
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Prevalence and Correlates of Subclinical Atherosclerosis in Alaska Eskimos
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Low incidence of schizophrenia in British Columbia coastal Indians.
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Flagged first, then by citations
3 of the 110 references couldn’t be matched to a known paper.
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Alternative Sources of n-3 Long-Chain Polyunsaturated Fatty Acids in Marine Microalgae
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Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes
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Improved utilization of fish waste by anaerobic digestion following omega-3 fatty acids extraction
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Characteristics of Green Seaweeds from Seribu Islands and Sekotong West Nusa Tenggara Antioxidant
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Valorisation of fish waste biomass through recovery of nutritional lipids and biogas
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Evaluation of OM3-PL/FFA Pharmacokinetics After Single and Multiple Oral Doses in Healthy Volunteers
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Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
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Diet, Inflammation, Gut Microbiome, and Mental Health
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Additional file 8 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946267
Additional file 7 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946264
Additional file 1 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946246
Additional file 2 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946249
Additional file 5 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946258
Additional file 3 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946252
Additional file 4 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946255
Additional file 6 of Can Omega-3 prevent the accidence of stroke: a mendelian randomization study
Xi, C., Zhang, J., Liu, H., Tao, S., Xie, Y., Liu, J., Tong, C., Tian, D., Ye, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26946261
- Authors
- PATEL, J. V., TRACEY, I., HUGHES, E. A., & LIP, G. Y.
- Affiliations
- Birmingham City Hospital (GB)
- Corresponding author
- LIP, G.Y.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 8
- Issue
- 10
- Pages
- 2095-2104
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W1512707865
- Cited by
- 32
- References
- 110
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 3 · 2015: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- omega-3 polyunsaturated fatty acids, cardiovascular disease, ethnicity, ethnic differences, dietary supplementation, nutrition transition, cardiovascular risk, Mediterranean diet
- MeSH terms
- Cardiovascular Diseases, Cross-Sectional Studies, Cultural Characteristics, Fatty Acids, Unsaturated, Glucose, Humans, Hypertension, Obesity, Research Design, Risk, Risk Factors, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Treatment Outcome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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