Cited by 1,036Statistical Methods in EpidemiologyHistorical and modern epidemiology studiesAdvanced Causal Inference Techniques

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PROPORTION OF DISEASE CAUSED OR PREVENTED BY A GIVEN EXPOSURE, TRAIT OR INTERVENTION1

MIETTINEN, OLLI S.·1974·American Journal of Epidemiology

DOI 10.1093/oxfordjournals.aje.a121617

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Abstract

The structures of two epidemiologic parameters are explored. One, the “etiologic fraction, ” relates to markers of increased risk, and it is the proportion of disease attributable to the marker and/or to factors associated with it. The other, the “prevented fraction, ” is the equivalent of this for a marker of reduced risk. It is shown that both parameters depend—in different ways—-on the frequency of the marker among cases of the disease, and on the “standardized morbidity ratio” for those with the marker. Point estimation of these parameters is often straight-forward, particularly in case-control studies.

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Untitled work
Painter (1985) · doi:10.1002/1097-0142(19850501)55:9

Authors: MIETTINEN, O. S.
Corresponding author: MIETTINEN, OLLI S.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1974-05
Volume: 99
Issue: 5
Pages: 325-332
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a121617
OpenAlex: W1953501928
Cited by: 1,036
References: 0
Citations by year: 2026: 24 · 2025: 34 · 2024: 41 · 2023: 35 · 2022: 26 · 2021: 35 · 2020: 39 · 2019: 40 · 2018: 31 · 2017: 22 · 2016: 27 · 2015: 25 · 2014: 28 · 2013: 22 · 2012: 26
FWCI: 7.80
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Health Sciences › Medicine › Epidemiology › Historical and modern epidemiology studies
Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
Keywords: population attributable fraction, prevented fraction, attributable fraction, risk indicators, standardized morbidity ratio, case-control study, disease prevention
MeSH terms: Coffee, Coronary Disease, Drinking, Epidemiologic Methods, Humans, Hypercholesterolemia, Hypertension, Models, Theoretical, Morbidity, Myocardial Infarction, Population, Preventive Medicine, Smoking, Statistics as Topic

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PROPORTION OF DISEASE CAUSED OR PREVENTED BY A GIVEN EXPOSURE, TRAIT OR INTERVENTION1

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