Fallopian tube sperm perfusion (FSP) versus intra-uterine insemination (IUI) in the treatment of unexplained infertility: a prospective randomized study
Abstract
Prospective randomization of 60 couples with unexplained infertility was performed for treatment either with intrauterine insemination (IUI), using a volume of 0.5 ml of the inseminate, or Fallopian tube sperm perfusion (FSP), using a volume of 4 ml of inseminate. The protocols for ovarian stimulation and induction of ovulation were the same in the two groups. The two groups were similar concerning age of the female at the start of treatment and the number of follicles > 15 mm diameter, the serum oestradiol concentrations and the endometrial thickness on the day of human chorionic gonadotrophin (HCG) administration. The mean (+/- SD) number of motile spermatozoa inseminated was significantly higher in the FSP group than in the IUI group (52 +/- 5 x 10(6) and 28 +/- 3 x 10(6) respectively). In the FSP group, 30 women were given a total of 52 treatment cycles; 14 clinical pregnancies occurred in this group, giving a pregnancy rate of 26.9% per cycle and 46.7% per woman. In the IUI group, 28 women were given a total of 51 treatment cycles; five clinical pregnancies occurred, giving a pregnancy rate of 9.8% per cycle and 17.9% per woman. The pregnancy rates per cycle and per woman in the FSP group were significantly higher than in the IUI group (P < 0.05, chi-square test). This study indicates that in the treatment of couples with unexplained infertility, Fallopian tube sperm perfusion (FSP) is more successful than intra-uterine insemination (IUI).
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As stricter criteria for normal morphology were used, the percentage of normal forms decreased from 63% in 1983-1985, to 52% in 1986-1995, and to 38% in 1996-1998.
“As stricter criteria for normal morphology were used (24), the percentage of normal forms decreased from 63% in the period 1983-1985, to 52% in the period 1986 -1995, and to 38% in the period 1996 -1998.”
From Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm (1999) · cites this paper as [24]
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- Authors
- Kahn, J. A., Sunde, A., Koskemies, A., von Düring, V., Sørdal, T., Christensen, F., & Molne, K.
- Affiliations
- Norwegian University of Science and Technology (NO)
- University of Helsinki (FI)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-06
- Volume
- 8
- Issue
- 6
- Pages
- 890-894
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1895489457
- Cited by
- 60
- References
- 0
- Citations by year
- 2023: 5 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- intrauterine insemination, unexplained infertility, assisted reproduction, clinical pregnancy rate, ovulation induction
- MeSH terms
- Adult, Fallopian Tubes, Female, Humans, Infertility, Female, Insemination, Artificial, Homologous, Male, Perfusion, Pregnancy, Prospective Studies, Sperm Count
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