The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse
Abstract
This report describes the development of obesity syndromes in mice caused by two autosomal recessive mutations, fat (fat), located on chromosome 8, and tubby (tub), located on chromosome 7. Both mutations cause slowly developing but ultimately severe obesity conditions. Although hyperinsulinemia, hyperactivity of the beta cell of the islets of Langerhans, and beta-cell degranulation are consistent features, these obesity syndromes do not progress to severe diabetes. The many different single-gene mutations in the mouse that produce obesity-diabetes syndromes of varying degrees of severity make the mutant mouse a powerful tool for analyzing the number and nature of the primary defects than can cause obesity states.
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Citations
Cites
Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis
Bray, G. A., & York, D. A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.719 · Cited by 1,132
Cited by
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725
Naggert, J. K., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouille, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J., & Leiter, E. H. (1995) · Nature Genetics · doi:10.1038/ng0695-135 · Cited by 663
Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family
Kleyn, P. W., Fan, W., Kovats, S. G., Lee, J. J., Pulido, J. C., Wu, Y., Berkemeier, L. R., Misumi, D. J., Holmgren, L., Charlat, O., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81104-6 · Cited by 375
Regulation of Body Weight in Humans
Jéquier, E., & Tappy, L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.451 · Cited by 373
Metadata
- Authors
- Coleman, D. L., & Eicher, E. M.
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-11
- Volume
- 81
- Issue
- 6
- Pages
- 424-427
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W2153798846
- Cited by
- 276
- References
- 1
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse. https://app.cochat.ai/papers/10.1093/oxfordjournals.jhered.a111019
- The paper
- Coleman, D. L., & Eicher, E. M. (1990). Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse. Journal of Heredity. https://doi.org/10.1093/oxfordjournals.jhered.a111019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
