The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
Open accessAbstract
We have attempted to quantify the frequency and effects of slightly deleterious mutations (SDMs), those that have selective effects close to the reciprocal of the effective population size of a species, by comparing the level of selective constraint in protein-coding genes of related species that have different present-day effective population sizes. In our two comparisons, the species with the smaller effective population size showed lower constraint, implying that SDMs had become fixed. The fixation of SDMs was supported by the observation of a higher fraction of radical to conservative amino acid substitutions in species with smaller effective population sizes. The fraction of strongly deleterious mutations (which rarely become fixed) is >70% in most species. Only approximately 10% or fewer of mutations seem to behave as SDMs, but SDMs could comprise a substantial fraction of mutations in protein-coding genes that have a chance of becoming fixed between species.
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Citations
Cites
Slightly Deleterious Mutant Substitutions in Evolution
OHTA, T. (1973) · Nature · doi:10.1038/246096a0 · Cited by 1,104
Goodman, M., Porter, C. A., Czelusniak, J., Page, S. L., Schneider, H., Shoshani, J., Gunnell, G., & Groves, C. P. (1998) · Molecular Phylogenetics and Evolution · doi:10.1006/mpev.1998.0495 · Cited by 743
On the constancy of the evolutionary rate of cistrons
Ohta, T., & Kimura, M. (1971) · Journal of Molecular Evolution · doi:10.1007/bf01659391 · Cited by 322
Cited by
Initial sequence of the chimpanzee genome and comparison with the human genome
The Chimpanzee Sequencing and Analysis Consortium (2005) · Nature · doi:10.1038/nature04072 · Cited by 2,459
Kryukov, G. V., Pennacchio, L. A., & Sunyaev, S. R. (2007) · The American Journal of Human Genetics · doi:10.1086/513473 · Cited by 598
Widespread Genomic Signatures of Natural Selection in Hominid Evolution
McVicker, G., Gordon, D., Davis, C., & Green, P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000471 · Cited by 456
The distribution of fitness effects of new deleterious amino acid mutations in humans.
Eyre-Walker, A., Woolfit, M., & Phelps, T. (2006) · Genetics · doi:10.1534/genetics.106.057570 · Cited by 377
Self-citationThe genomic rate of adaptive evolution
EYREWALKER, A. (2006) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.06.015 · Cited by 316
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Metadata
- Authors
- Eyre-Walker, A., Keightley, P. D., Smith, N. G. C., & Gaffney, D.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 19
- Issue
- 12
- Pages
- 2142-2149
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2107495006
- Cited by
- 208
- References
- 3
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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