Cited by 84Genomics and Phylogenetic StudiesRNA and protein synthesis mechanismsEvolution and Paleontology Studies

Patterns of ribosomal RNA evolution in salamanders.

A. Larson, Alex C. C. Wilson·1989·Molecular Biology and Evolution

Abstract

Sequence comparisons are presented for four segments of the large subunit of ribosomal RNA, including divergent domains D7a and D7b, portions of the large divergent domains D2, D3, and D8, and evolutionarily conservative sequences flanking divergent domains. These results resolve phylogenetic relationships among exemplars of seven families of salamanders and the three amphibian orders. Phylogenetic analysis confirms the prediction that divergent domains feature the highest relative rates of base substitution and length variation within the ribosome, but the divergent domains evolve more slowly than nuclear noncoding DNA and the silent sites of structural genes. Base substitutions demonstrate approximately twice as many transitions as transversions and an uneven distribution among sites within the divergent domains but no apparent bias in base composition. Length mutations are primarily small insertions and deletions, with deletions predominating. The divergent domains appear to be a good source of phylogenetic information for evolutionary events occurring approximately 100-200 million years ago.

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Crossref · 10.1093/oxfordjournals.molbev.a040539

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  • In vertebrate mt-rDNA as well as in nuclear rDNA, transversions tend to occur much less frequently than transitions.

    “In vertebrate mt-rDNA (Hixson and Brown 1986) as well as in nuclear rDNA (Larson and Wilson 1989;Hedges et al. 1990), transversions tend to occur much less frequently than transitions.”

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Authors
Larson, A., & Wilson, A. C. C.
Affiliations
University of California, Berkeley (US)
Venue
Molecular Biology and Evolution
Published
1989-03
Volume
6
Issue
2
Pages
131-54
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
OpenAlex
W2281560970
Cited by
84
References
58
Citations by year
2021: 1 · 2020: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
3.16
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Biology and Evolution (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
Keywords
ribosomal RNA evolution, salamanders, large subunit rRNA, phylogenetic relationships, base substitution rate, indels, transitions and transversions, molecular clock
MeSH terms
Animals, Base Sequence, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, RNA, Ribosomal, 28S, Sequence Homology, Nucleic Acid, Species Specificity, Urodela, Caudata

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