Patterns of ribosomal RNA evolution in salamanders.
Abstract
Sequence comparisons are presented for four segments of the large subunit of ribosomal RNA, including divergent domains D7a and D7b, portions of the large divergent domains D2, D3, and D8, and evolutionarily conservative sequences flanking divergent domains. These results resolve phylogenetic relationships among exemplars of seven families of salamanders and the three amphibian orders. Phylogenetic analysis confirms the prediction that divergent domains feature the highest relative rates of base substitution and length variation within the ribosome, but the divergent domains evolve more slowly than nuclear noncoding DNA and the silent sites of structural genes. Base substitutions demonstrate approximately twice as many transitions as transversions and an uneven distribution among sites within the divergent domains but no apparent bias in base composition. Length mutations are primarily small insertions and deletions, with deletions predominating. The divergent domains appear to be a good source of phylogenetic information for evolutionary events occurring approximately 100-200 million years ago.
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In vertebrate mt-rDNA as well as in nuclear rDNA, transversions tend to occur much less frequently than transitions.
“In vertebrate mt-rDNA (Hixson and Brown 1986) as well as in nuclear rDNA (Larson and Wilson 1989;Hedges et al. 1990), transversions tend to occur much less frequently than transitions.”
From Phylogeny of the Bovidae (Artiodactyla, Mammalia), based on mitochondrial ribosomal DNA sequences. (1992) · cites this paper as Larson and Wilson 1989
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- Authors
- Larson, A., & Wilson, A. C. C.
- Affiliations
- University of California, Berkeley (US)
- ORCID
- Alex C. C. Wilson
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-03
- Volume
- 6
- Issue
- 2
- Pages
- 131-54
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2281560970
- Cited by
- 84
- References
- 58
- Citations by year
- 2021: 1 · 2020: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Keywords
- ribosomal RNA evolution, salamanders, large subunit rRNA, phylogenetic relationships, base substitution rate, indels, transitions and transversions, molecular clock
- MeSH terms
- Animals, Base Sequence, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, RNA, Ribosomal, 28S, Sequence Homology, Nucleic Acid, Species Specificity, Urodela, Caudata
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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